Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Marcus Ruscetti"'
Autor:
Arnab Ghosh, Judith Michels, Riccardo Mezzadra, Divya Venkatesh, Lauren Dong, Ricardo Gomez, Fadi Samaan, Yu-Jui Ho, Luis Felipe Campesato, Levi Mangarin, John Fak, Nathan Suek, Aliya Holland, Cailian Liu, Mohsen Abu-Akeel, Yonina Bykov, Hong Zhong, Kelly Fitzgerald, Sadna Budhu, Andrew Chow, Roberta Zappasodi, Katherine S. Panageas, Olivier de Henau, Marcus Ruscetti, Scott W. Lowe, Taha Merghoub, Jedd D. Wolchok
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
In addition to playing a major role in tumor cell biology, p53 generates a microenvironment that promotes antitumor immune surveillance via tumor-associated macrophages. We examined whether increasing p53 signaling in the tumor microenvironment influ
Externí odkaz:
https://doaj.org/article/4dd0c33291a24e69965b3018d2f98727
Autor:
Loretah Chibaya, Katherine C. Murphy, Kelly D. DeMarco, Sneha Gopalan, Haibo Liu, Chaitanya N. Parikh, Yvette Lopez-Diaz, Melissa Faulkner, Junhui Li, John P. Morris, Yu-jui Ho, Sachliv K. Chana, Janelle Simon, Wei Luan, Amanda Kulick, Elisa de Stanchina, Karl Simin, Lihua Julie Zhu, Thomas G. Fazzio, Scott W. Lowe, Marcus Ruscetti
Publikováno v:
Nature Cancer.
Autor:
Scott W. Lowe, Charles L. Sawyers, Cory Abate-Shen, Lukas E. Dow, John E. Wilkinson, Elisa de Stanchina, Philip A. Watson, Francisco J. Sánchez-Rivera, Nelson R. Salgado, Katarzyna Rybczyk, Sha Tian, Corina Amor, Amanda Kulick, Leah Zamechek, Kaloyan M. Tsanov, Francisco M. Barriga, Teng Han, Judith Feucht, Wassim Abida, Min Zou, Timour Baslan, Yu-Jui Ho, Zhen Cao, Marcus Ruscetti, Josef Leibold
Supplementary Figures and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198a864b097bc309e6ff0146b52c0bbb
https://doi.org/10.1158/2159-8290.22535048.v1
https://doi.org/10.1158/2159-8290.22535048.v1
Autor:
Hong Wu, Ningshu Liu, Tanu Shenoy, Marcus Ruscetti, Liuzhen Zhang, Weilong Guo, Zhi Qi, Yongkang Zou
Figure S1. Effects of BAY1082439 on cell apoptosis and cell cycle; Figure S2. BAY1082439 is well tolerated in vivo; Figure S3. BAY1082439 treatment impedes prostate tumor invasion; Figure S4. BAY1082439 treatment inhibit CRPC growth in castrated CP m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ec0d180dcf79cb3760387d0df322db
https://doi.org/10.1158/1535-7163.22504362
https://doi.org/10.1158/1535-7163.22504362
Autor:
Hong Wu, Ningshu Liu, Tanu Shenoy, Marcus Ruscetti, Liuzhen Zhang, Weilong Guo, Zhi Qi, Yongkang Zou
Targeting the PI3K pathway is a promising strategy for treating prostate cancers with PTEN-loss. However, current anti-PI3K therapies fail to show long lasting in vivo effects. We find that not only the PI3Kα- and PI3kβ-isoforms, but also PI3Kδ, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4bb1d8c431596137b09588702b9d0a
https://doi.org/10.1158/1535-7163.c.6537711
https://doi.org/10.1158/1535-7163.c.6537711
Autor:
Scott W. Lowe, Charles L. Sawyers, Cory Abate-Shen, Lukas E. Dow, John E. Wilkinson, Elisa de Stanchina, Philip A. Watson, Francisco J. Sánchez-Rivera, Nelson R. Salgado, Katarzyna Rybczyk, Sha Tian, Corina Amor, Amanda Kulick, Leah Zamechek, Kaloyan M. Tsanov, Francisco M. Barriga, Teng Han, Judith Feucht, Wassim Abida, Min Zou, Timour Baslan, Yu-Jui Ho, Zhen Cao, Marcus Ruscetti, Josef Leibold
To study genetic factors influencing the progression and therapeutic responses of advanced prostate cancer, we developed a fast and flexible system that introduces genetic alterations relevant to human disease directly into the prostate glands of mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31669b3f610693536fcf69ae0d284582
https://doi.org/10.1158/2159-8290.c.6547748.v1
https://doi.org/10.1158/2159-8290.c.6547748.v1
Supplementary Figure S3. EMT-like and mesenchymal tumor cells have enhanced tumor-initiating capacity in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0325908235758e5bccdf8a883e4917
https://doi.org/10.1158/0008-5472.22405856.v1
https://doi.org/10.1158/0008-5472.22405856.v1
Autor:
Hong Wu, Martin Gleave, Jiaoti Huang, Linh M. Tran, Allen Zhi, Marcus Ruscetti, Naoko Kobayashi, David J. Mulholland
PDF file - 1.5MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdf5228e1f791a21eb2d7fab8e9c781
https://doi.org/10.1158/0008-5472.22391619.v1
https://doi.org/10.1158/0008-5472.22391619.v1
Autor:
Hong Wu, Martin Gleave, Jiaoti Huang, Linh M. Tran, Allen Zhi, Marcus Ruscetti, Naoko Kobayashi, David J. Mulholland
PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic burden that frequently accomp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::419ba4d697f635f83d1744d2da14b229
https://doi.org/10.1158/0008-5472.c.6503304.v1
https://doi.org/10.1158/0008-5472.c.6503304.v1
Supplementary Figure Legends. Legend for Supplementary Figures S1-S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0178b9ab4b2b84ced34ef0888b08d546
https://doi.org/10.1158/0008-5472.22405865.v1
https://doi.org/10.1158/0008-5472.22405865.v1