Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Marcus R, Clark"'
Autor:
Adam J. Fike, Sathi Babu Chodisetti, Nathaniel E. Wright, Kristen N. Bricker, Phillip P. Domeier, Mark Maienschein-Cline, Aaron M. Rosenfeld, Sara A. Luckenbill, Julia L. Weber, Nicholas M. Choi, Eline T. Luning Prak, Malay Mandal, Marcus R. Clark, Ziaur S.M. Rahman
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112512- (2023)
Summary: Germinal centers (GCs), sites of antibody affinity maturation, are organized into dark (DZ) and light (LZ) zones. Here, we show a B cell-intrinsic role for signal transducer and activator of transcription 3 (STAT3) in GC DZ and LZ organizati
Externí odkaz:
https://doaj.org/article/90bb71ba5bd34d068395ef2779c48824
IRF4 expression by lung dendritic cells drives acute but not Trm cell–dependent memory Th2 responses
Autor:
Daniel F. Camacho, Tania E. Velez, Maile K. Hollinger, Esther Wang, Chanie L. Howard, Eli P. Darnell, Domenick E. Kennedy, Paulette A. Krishack, Cara L. Hrusch, Marcus R. Clark, James J. Moon, Anne I. Sperling
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
Expression of the transcription factor interferon regulatory factor 4 (IRF4) is required for the development of lung conventional DCs type 2 (cDC2s) that elicit Th2 responses, yet how IRF4 functions in lung cDC2s throughout the acute and memory aller
Externí odkaz:
https://doaj.org/article/7651a0c359e14735b6b32d72add5e4f5
Autor:
Yuta Asano, Joe Daccache, Dharmendra Jain, Kichul Ko, Andrew Kinloch, Margaret Veselits, Donald Wolfgeher, Anthony Chang, Michelle Josephson, Patrick Cunningham, Anat Tambur, Aly A. Khan, Shiv Pillai, Anita S. Chong, Marcus R. Clark
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Intrarenal B cells are indicative of poor prognosis in human renal allografts. Here the authors use single cell RNA sequencing to examine how intrarenal B cells contribute to renal rejection and find a population of innate B cells reactive to renal-s
Externí odkaz:
https://doaj.org/article/fda8e4a80e2a40b1a77ed6fa113be6ca
Autor:
Rebecca Abraham, Madeleine S. Durkee, Junting Ai, Margaret Veselits, Gabriel Casella, Yuta Asano, Anthony Chang, Kichul Ko, Charles Oshinsky, Emily Peninger, Maryellen L. Giger, Marcus R. Clark
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
BACKGROUND In human lupus nephritis (LN), tubulointerstitial inflammation (TII) on biopsy predicts progression to end-stage renal disease (ESRD). However, only about half of patients with moderate-to-severe TII develop ESRD. We hypothesized that this
Externí odkaz:
https://doaj.org/article/48c07970fe1844bdb97aea821879975f
Autor:
Jeff W. Chen, Jean-Nicolas Schickel, Nikolaos Tsakiris, Joel Sng, Florent Arbogast, Delphine Bouis, Daniele Parisi, Ruchi Gera, Joshua M. Boeckers, Fabien R. Delmotte, Margaret Veselits, Catharina Schuetz, Eva-Maria Jacobsen, Carsten Posovszky, Ansgar S. Schulz, Klaus Schwarz, Marcus R. Clark, Laurence Menard, Eric Meffre
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Although negative selection of developing B cells in the periphery is well described, yet poorly understood, evidence of naive B cell positive selection remains elusive. Using 2 humanized mouse models, we demonstrate that there was strong skewing of
Externí odkaz:
https://doaj.org/article/e5d69aac33524de49d493bed037a80ad
Autor:
Anthony Chang, Maryellen Giger, Marcus R Clark, Madeleine Durkee, Rebecca Abraham, Junting Ai, Kichul Ko
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/168f4f73f0754181b1d2ef74fd07f4d3
Autor:
Jason B. Wong, Susannah L. Hewitt, Lynn M. Heltemes-Harris, Malay Mandal, Kristen Johnson, Klaus Rajewsky, Sergei B. Koralov, Marcus R. Clark, Michael A. Farrar, Jane A. Skok
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
B-1a B cells are innate-like cells with biased reactivity to bacteria and self-antigens. Here the authors show that reduced interleukin-7 in developing fetal liver-derived pro-B cells induces premature immunoglobulin κ rearrangement, alleviating the
Externí odkaz:
https://doaj.org/article/187b8150da99438da49e30693e5b9441
Autor:
Domenick E. Kennedy, Marcus R. Clark
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular a
Externí odkaz:
https://doaj.org/article/18c37b345bdf44469ccadb913bc84edd
Autor:
Victoria Lee, Donald M. Rodriguez, Nicole K. Ganci, Sharon Zeng, Junting Ai, Jaime L. Chao, Matthew T. Walker, Christine H. Miller, David E. J. Klawon, Mary H. Schoenbach, Domenick E. Kennedy, Mark Maienschein-Cline, Nicholas D. Socci, Marcus R. Clark, Peter A. Savage
Publikováno v:
Nature Immunology. 24:487-500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e29bc41fc8e2bb64252e9fa615256c9
https://doi.org/10.1038/s41590-023-01425-0
https://doi.org/10.1038/s41590-023-01425-0
Autor:
Andrew J. Kinloch, Yuta Asano, Azam Mohsin, Carole Henry, Rebecca Abraham, Anthony Chang, Christine Labno, Patrick C. Wilson, Marcus R. Clark
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
In human lupus nephritis, tubulointerstitial inflammation (TII) is associated with in situ expansion of B cells expressing anti-vimentin antibodies (AVAs). The mechanism by which AVAs are selected is unclear. Herein, we demonstrate that AVA somatic h
Externí odkaz:
https://doaj.org/article/a8a7ac932c614a3ebf5baee261c39b79