Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marcus Peacock"'
Autor:
Sarah L. Martin, Dawn Yates, Grant Wishart, Ignacio Munoz-Sanjuan, Wesley Blackaby, Ovadia Lazari, Roger Cachope, Amanda Van de Poël, Leticia Toledo-Sherman, Esmieu William R K, Ivan Angulo-Herrera, Celia Dominguez, Rebecca E. Jarvis, Helen C. Cox, Amy Barnard, Graham Jones, Marcus Peacock, Sung-Wook Jang, Perla Breccia, Jennifer R. Bate, Cole Clissold, Philip Leonard, Maria Eznarriaga, Marieke Lamers, Mark Rose, George McAllister, Kim L. Matthews, Huw D. Vater
Publikováno v:
Journal of medicinal chemistry. 64(8)
Our group has recently shown that brain-penetrant ataxia telangiectasia-mutated (ATM) kinase inhibitors may have potential as novel therapeutics for the treatment of Huntington's disease (HD). However, the previously described pyranone-thioxanthenes
Autor:
Marcus Peacock, Susan E. Dudley
Publikováno v:
Supreme Court Economic Review. 24:49-99
This paper explores the motivations and institutional incentives of participants involved in the development of regulation aimed at reducing health risks, with a goal of understanding and i...
Autor:
Marcus Peacock
Publikováno v:
Supreme Court Economic Review. 24:255-257
Autor:
Celine Cano, Bernard T. Golding, Sonsoles Rodriguez-Aristegui, Roger J. Griffin, Sara L. Payne, Ian R. Hardcastle, Nahida Parveen, Julia Bardos, Marcus Peacock
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3649-3653
Replacement of the core heterocycle of a defined series of chromen-4-one DNA-PK inhibitors by the isomeric chromen-2-one (coumarin) and isochromen-1-one (isocoumarin) scaffolds was investigated. Structure-activity relationships for DNA-PK inhibition
Autor:
Alyson Fox, Marcus Peacock, Alice Chen, Alex Groarke, Christopher Thomas Brain, Yvonne Loong, Jean-Philippe Courade, Alex Dyson, Mohammed Yaqoob
Publikováno v:
Pain. 116:129-137
CT-3 (ajulemic acid) is a synthetic analogue of a metabolite of Delta9-tetrahydrocannabinol that has reported analgesic efficacy in neuropathic pain states in man. Here we show that CT-3 binds to human cannabinoid receptors in vitro, with high affini
Autor:
Iain F. James, Stuart Bevan, Janet Winter, Marcus Peacock, Elsa Phillips, Melanie Clarke, Humphrey P. Rang, Jonathan Savidge, Christy Toms, Anne Chambers, Michael Webb, Peter McIntyre, Natasha Weerasakera, Kirti Shah, Linda M. McLatchie
Publikováno v:
British Journal of Pharmacology. 132:1084-1094
Vanilloid receptors (VR1) were cloned from human and rat dorsal root ganglion libraries and expressed in Xenopus oocytes or Chinese Hamster Ovary (CHO) cells. Both rat and human VR1 formed ligand gated channels that were activated by capsaicin with s
Autor:
Hart Terance William, Kara McNair, Isabelle Lyothier, Christopher Thomas Brain, Marcus Peacock, Paul R. Coote, and Mohammed Yaqoob, Iain F. James, Luigi La Vecchia, Adam Kesingland, Jiri Zadrobilek, Edward K. Dziadulewicz, Ulrich Schopfer, Werner Huber, Andrew James Culshaw, Adrian J. Fisher, Lee Edwards, Alyson Fox, Portmann Robert, † Cathal O'Farrell, Alex Groarke, Stuart Bevan, Andrew J. Davis, Clive Gentry, Yvonne Loong
Publikováno v:
Journal of medicinal chemistry. 50(16)
Selective activation of peripheral cannabinoid CB1 receptors has the potential to become a valuable therapy for chronic pain conditions as long as central nervous system effects are attenuated. A new class of cannabinoid ligands was rationally design
Autor:
Marcus Peacock, Bernard T. Golding, Roger J. Griffin, Karen Haggerty, Ian R. Hardcastle, Celine Cano
Publikováno v:
Organic & Biomolecular Chemistry. 8:1922
Substitution at the 3-position of the dibenzothiophen-4-yl ring of 8-(dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one NU7441, a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor, with propyl, allyl or methyl enabled the se
Autor:
Nahida Parveen, Aaron Cranston, Niall M. B. Martin, William Deacon, Kerry Shea, Graeme C. M. Smith, Mark Albertella, Marcus Peacock, Julia Bardos, Keith Allan Menear
Publikováno v:
Molecular Cancer Therapeutics. 8:A116-A116
DNA double strand breaks (DSBs) are profoundly cytotoxic unless rapidly repaired. Non-homologous end joining (NHEJ) is the predominant pathway of DSB repair in mammalian cells. DNA-dependent protein kinase (DNA-PK), a member of the PI3-kinase like ki
Autor:
Marcus Peacock
Publikováno v:
Science. 316:53-53
As Erik Stokstad's article “EPA draws fire over air-review revisions” (News of the Week, 15 Dec. 2006, p. [1672][1]) notes, everyone agrees that the U.S. Environmental Protection Agency's (EPA) process for developing ambient air quality standards