Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marcus P. D. Hatfield"'
Autor:
Daniel Knappe, Ralf Hoffmann, Nicholas Palermo, Marcus P. D. Hatfield, Sándor Lovas, Tina Goldbach, Norbert Sträter, Stefanie Weinert
Publikováno v:
Protein & Peptide Letters. 23:1061-1071
The bacterial protein DnaK promotes folding of newly synthesized polypeptide chains, refolding of misfolded proteins, and protein trafficking. Assisted refolding is especially important under stress conditions induced by antibiotic therapies reducing
Autor:
Marcus P. D. Hatfield, Sándor Lovas
Publikováno v:
Current Pharmaceutical Design. 20:3303-3313
The potential energy hyper-surface of a protein relates the potential energy of the protein to its conformational space. This surface is useful in determining the native conformation of a protein or in examining a statistical-mechanical ensemble of s
Autor:
Sándor Lovas, Marcus P. D. Hatfield
Publikováno v:
Protein & Peptide Letters. 19:616-624
Hsp70 is a highly conserved protein that refolds misfolded proteins and has numerous housekeeping functions which regulate apoptosis and other cell activities. Hsp70 consists of a nucleotide binding domain which binds ATP and a substrate binding doma
Autor:
Laura Scolaro, Ralf Hoffmann, Eva Surmacz, Gabriella Beko, Suode Zhang, Andras Sztodola, Julia Olah, John D. Wade, Ilona Kovalszky, Laszlo Otvos, Marco Cassone, Marcus P. D. Hatfield, Sándor Lovas, Daniel Knappe
Publikováno v:
Biopolymers. 96:117-125
Leptin, a multifunctional hormone, controls various processes in both the central nervous system and in peripheral tissues. Because of the presence of multiple leptin/receptor (ObR) interaction sites and diverse leptin activities, the literature lack
Leptin-based glycopeptide induces weight loss and simultaneously restores fertility in animal models
Autor:
Andras Sztodola, Rita Ferla, Laszlo Otvos, Sándor Lovas, Julia Olah, Ilona Kovalszky, Laura Scolaro, Marcus P. D. Hatfield, Marco Cassone, Eva Surmacz
Publikováno v:
Diabetes, Obesity and Metabolism. 12:393-402
Aim: To design, manufacture and test a second generation leptin receptor (ObR) agonist glycopeptide derivative. The major drawback to current experimental therapies involving leptin protein is the appearance of treatment resistance. Our novel peptido
Autor:
Huizhan Liu, Marcus P. D. Hatfield, Kirk W. Beisel, Sándor Lovas, David Z.Z. He, Jie Tang, Jason L. Pecka
Prestin is the motor protein of cochlear outer hair cells. Its unique capability to perform direct, rapid, and reciprocal electromechanical conversion depends on membrane potential and interaction with intracellular anions. How prestin senses the vol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937207648a6080eb6aec7e2a67243a0a
https://europepmc.org/articles/PMC4591817/
https://europepmc.org/articles/PMC4591817/
Publikováno v:
The journal of physical chemistry. B. 115(17)
The conformational stability of the β-hairpin miniprotein, CLN025, a variant of chignolin in which the N- and C-terminal glycines are replaced by tyrosines, in various concentrations of guanidinium chloride (GdmCl) and urea was examined by molecular
Publikováno v:
The journal of physical chemistry. B. 114(8)
Molecular dynamics simulations of a beta-hairpin miniprotein, CLN025, were performed to examine the conformational stability of the peptide in H(2)O at 278, 300, 333, and 363 K, as well as in TFE, MeOH, and DMSO at 300 K. CLN025 is a variant of the C
Publikováno v:
Biopolymers. 93(5)
Electronic and vibrational circular dichroism are often used to determine the secondary structure of proteins, because each secondary structure has a unique spectrum. Little is known about the vibrational circular dichroic spectroscopic features of t
Publikováno v:
The journal of physical chemistry. B. 112(11)
The tertiary structure of the TC5b miniprotein is stabilized by inter-residue interactions of the Trp-cage, which is composed of a Tyr and several Pro residues surrounding a central Trp residue. The interactions include Ar-Ar (aromatic side-chain-aro