Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Marcus O W Grimm"'
Autor:
Anke Wittmann, Marcus O W Grimm, Harry Scherthan, Marion Horsch, Johannes Beckers, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis, Steven J Ford, Neal C Burton, Daniel Razansky, Dietrich Trümbach, Michaela Aichler, Axel Karl Walch, Julia Calzada-Wack, Frauke Neff, Wolfgang Wurst, Tobias Hartmann, Thomas Floss
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164298 (2016)
Sphingolipids and the derived gangliosides have critical functions in spermatogenesis, thus mutations in genes involved in sphingolipid biogenesis are often associated with male infertility. We have generated a transgenic mouse line carrying an inser
Externí odkaz:
https://doaj.org/article/af78c7a2bc0546e29b95d8ed556a9ed4
Autor:
Marcus O W Grimm, Eva G Zinser, Sven Grösgen, Benjamin Hundsdörfer, Tatjana L Rothhaar, Verena K Burg, Lars Kaestner, Thomas A Bayer, Peter Lipp, Ulrike Müller, Heike S Grimm, Tobias Hartmann
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34095 (2012)
Gangliosides are important players for controlling neuronal function and are directly involved in AD pathology. They are among the most potent stimulators of Aβ production, are enriched in amyloid plaques and bind amyloid beta (Aβ). However, the mo
Externí odkaz:
https://doaj.org/article/97b810f1c3404c379a6fb004c8d572fb
Autor:
Sven Lyschik, Anna A. Lauer, Tanja Roth, Daniel Janitschke, Markus Hollander, Thorsten Will, Tobias Hartmann, Ron R. Kopito, Volkhard Helms, Marcus O. W. Grimm, Bianca Schrul
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cellular lipid metabolism is tightly regulated and requires a sophisticated interplay of multiple subcellular organelles to adapt to changing nutrient supply. PEX19 was originally described as an essential peroxisome biogenesis factor that selectivel
Externí odkaz:
https://doaj.org/article/973e0dd8de814098ba1e3f71dcb7244d
Autor:
Anna A. Lauer, Vu Thu Thuy Nguyen, Daniel Janitschke, Malena dos Santos Guilherme, Cornel M. Bachmann, Heike S. Grimm, Tobias Hartmann, Kristina Endres, Marcus O. W. Grimm
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15535 (2022)
Administration of systemic retinoids such as acitretin has not been approved yet for pediatric patients. An adverse event of retinoid-therapy that occurs with lower prevalence in children than in adults is hyperlipidemia. This might be based on the l
Externí odkaz:
https://doaj.org/article/e7e71da85e334f808d1a5d3d439b1b67
Autor:
Daniel Janitschke, Anna A. Lauer, Cornel M. Bachmann, Heike S. Grimm, Tobias Hartmann, Marcus O. W. Grimm
Publikováno v:
Nutrients, Vol 13, Iss 3, p 803 (2021)
Methylxanthines (MTX) are purine derived xanthine derivatives. Whereas naturally occurring methylxanthines like caffeine, theophylline or theobromine are widely consumed in food, several synthetic but also non-synthetic methylxanthines are used as ph
Externí odkaz:
https://doaj.org/article/59b41af1fcd646dd9fe6fb5245d7997c
Autor:
Daniel Janitschke, Anna A. Lauer, Cornel M. Bachmann, Martin Seyfried, Heike S. Grimm, Tobias Hartmann, Marcus O. W. Grimm
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9015 (2020)
Methylxanthines are a group of substances derived from the purine base xanthine with a methyl group at the nitrogen on position 3 and different residues at the nitrogen on position 1 and 7. They are widely consumed in nutrition and used as pharmaceut
Externí odkaz:
https://doaj.org/article/f1b97c9f8e8e453aaae1fcc87bcc3a55
Autor:
Kristina Endres, Jakob Winkler, Tobias Hartmann, Marcus O. W. Grimm, Lisa Gadomsky, Michael A. van der Kooij, Malena dos Santos Guilherme
Background:Function of the Amyloid Precursor Protein (AβPP) and its various cleavage products still is not unraveled down to the last detail. While its role as a source of the neurotoxic Amyloid beta (Aβ) peptides in Alzheimer’s Disease (AD) is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4660eed2d34dce90fda65731d0c33090
Autor:
Heike S. Grimm, Tobias Hartmann, Johannes Lehmann, Benjamin Hundsdörfer, Sven Grösgen, Valerie C. Zimmer, Tatjana L. Rothhaar, Viola J. Haupenthal, Marcus O. W. Grimm
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 3, Pp 5879-5898 (2013)
Alzheimer’s disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ec
Externí odkaz:
https://doaj.org/article/427f4cfb366f4035ac5a11123c7c8e72
Autor:
Marcus O. W. Grimm, Janine Mett, Anna A. Lauer, Heikki Tanila, Heike S. Grimm, Elena Leoni Theiss, Daniel Janitschke, Lea Victoria Griebsch, Tobias Hartmann, Hennariikka Koivisto
Publikováno v:
Cells; Volume 10; Issue 11; Pages: 2941
Cells
Cells, Vol 10, Iss 2941, p 2941 (2021)
Cells
Cells, Vol 10, Iss 2941, p 2941 (2021)
The accumulation of amyloid β-protein (Aβ) is one of the major pathological hallmarks of Alzheimer’s disease. Insulin-degrading enzyme (IDE), a zinc-metalloprotease, is a key enzyme involved in Aβ degradation, which, in addition to Aβ productio
Autor:
Marcus O. W. Grimm, Kristina Endres, Florian Schuck, Gert O. Pflugfelder, Tobias Hartmann, Nicolai M Stoye, Sven Reinhardt
Publikováno v:
Cellular and Molecular Life Sciences. 76:1005-1025
The ADAM10-mediated cleavage of transmembrane proteins regulates cellular processes such as proliferation or migration. Substrate cleavage by ADAM10 has also been implicated in pathological situations such as cancer or Morbus Alzheimer. Therefore, id