Výsledky vyhledávání - "Marcus Machin"

Decitabine Treatment of Tumor-Infiltrating Lymphocytes (TIL) during Ex Vivo Expansion Induces a More Memory-like Phenotype, Reduces Inhibitory Receptor Expression, and Increases Functionality

Autor: Yongliang Zhang, Andrew Yuhas, Marcus Machin, Rafael Cubas

Publikováno v: Transplantation and Cellular Therapy. 28:S216-S217

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09118cfc2d6e4503de3eb4611ef33edb
https://doi.org/10.1016/s2666-6367(22)00431-6

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Abstract 2746: Preclinical activity and manufacturing feasibility of genetically modified PDCD-1 knockout (KO) tumor-infiltrating lymphocyte (TIL) cell therapy

Autor: Arvind Natarajan, Anand Veerapathran, Adrian Wells, Kenneth Onimus, Marcus Machin, Seth Wardell, Jamie L. Blauvelt, Madan Jagasia, Rafael Cubas

Publikováno v: Cancer Research. 82:2746-2746

Background: Adoptive cell therapy with autologous TIL has demonstrated an objective response rate (ORR) of 36% in the post-immune checkpoint inhibitor (ICI) setting in patients (pts) with advanced/unresectable melanoma (Sarnaik JCO 2021), while in IC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0935057c07b99c068888f49dc1cb381
https://doi.org/10.1158/1538-7445.am2022-2746

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Abstract LB-110: Anti-OX40 agonistic antibody enhances ex vivo CD8+ TIL expansion with increased T-cell effector function

Autor: Marcus Machin, Krit Ritthipichai, Cecile Chartier, Maria Fardis

Publikováno v: Cancer Research. 78:LB-110

Adoptive T cell therapy (ACT) using tumor infiltrating lymphocytes (TILs) has demonstrated efficacy in metastatic melanoma patients, with ~50% objective responses. Amongst parameters recognized as important for the efficacy of ACT is a high proportio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c851518b6f62bd70495cce03f94079b7
https://doi.org/10.1158/1538-7445.am2018-lb-110

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K+ Channel Activation Promotes Tumor infiltrating Lymphocyte (TIL) Expansion and Enhances Expression of CCR7

Autor: Krit Ritthipichai, Marcus Machin, Michelle Simpson-Abelson, Christopher Mosychuk, Anand Veerapathran, Michael Lotze

Publikováno v: The Journal of Immunology. 198:198.1-198.1

Only two K+ channels are known to be expressed by T-cells. Activated effector T cells express high levels of Kv1.3; activated naïve and central memory T-cell subsets express high levels of KCa3.1. Overexpression of Kv1.3 in murine T-cells increases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1eeecbe7781227d61071c9fd9fb1973e
https://doi.org/10.4049/jimmunol.198.supp.198.1

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