Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Marcus M Maddox"'
Autor:
Chelsi D Cassilly, Marcus M Maddox, Philip T Cherian, John J Bowling, Mark T Hamann, Richard E Lee, Todd B Reynolds
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154932 (2016)
In order to expand the repertoire of antifungal compounds a novel, high-throughput phenotypic drug screen targeting fungal phosphatidylserine (PS) synthase (Cho1p) was developed based on antagonism of the toxin papuamide A (Pap-A). Pap-A is a cyclic
Externí odkaz:
https://doaj.org/article/0db1d88214b44e7e95619cf1a0f65d12
Autor:
Rakesh, David F Bruhn, Michael S Scherman, Lisa K Woolhiser, Dora B Madhura, Marcus M Maddox, Aman P Singh, Robin B Lee, Julian G Hurdle, Michael R McNeil, Anne J Lenaerts, Bernd Meibohm, Richard E Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87909 (2014)
The reductively activated nitroaromatic class of antimicrobials, which include nitroimidazole and the more metabolically labile nitrofuran antitubercular agents, have demonstrated some potential for development as therapeutics against dormant TB baci
Externí odkaz:
https://doaj.org/article/5a17b56fb20942aa854494bae86ab371
Autor:
Mingming Zhang, Allan M. Prior, Marcus M. Maddox, Wan-Jou Shen, Kirk E. Hevener, David F. Bruhn, Robin B. Lee, Aman P. Singh, Justin Reinicke, Charles J. Simmons, Julian G. Hurdle, Richard E. Lee, Dianqing Sun
Publikováno v:
ACS Omega, Vol 3, Iss 12, Pp 18343-18360 (2018)
Externí odkaz:
https://doaj.org/article/27abe659138b4f32a2e630d0506d1f8f
Autor:
Marcus M. Maddox, Charles J. Simmons, Mingming Zhang, Allan M. Prior, Kirk E. Hevener, David F. Bruhn, Dianqing Sun, Justin Reinicke, Julian G Hurdle, Aman P. Singh, Robin B. Lee, Wan-Jou Shen, Richard E. Lee
Publikováno v:
ACS Omega, Vol 3, Iss 12, Pp 18343-18360 (2018)
ACS Omega
ACS Omega
A series of novel chalcone and thiol-Michael addition analogues was synthesized and tested against Mycobacterium tuberculosis and other clinically significant bacterial pathogens. Previously reported chalcone-like antibacterials (1a–c and 2) were u
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4070-4076
Bacterial infections, caused by Mycobacterium tuberculosis and other problematic bacterial pathogens, continue to pose a significant threat to global public health. As such, new chemotype antibacterial agents are desperately needed to fuel and streng
Autor:
Yuk-Ching Tse-Dinh, Charles J. Simmons, Li Feng, Shayna Sandhaus, Gagandeep Narula, Dianqing Sun, Lissa S. Tsutsumi, Xiaoqian Wu, Julian G. Hurdle, Marcus M. Maddox, David F. Bruhn, Richard E. Lee, Zahidul Alam, Robin B. Lee
Publikováno v:
Journal of Medicinal Chemistry
On the basis of recently reported abyssinone II and olympicin A, a series of chemically modified flavonoid phytochemicals were synthesized and evaluated against Mycobacterium tuberculosis and a panel of Gram-positive and -negative bacterial pathogens
Autor:
Victoria Jones, Mary Jackson, Marcus M. Maddox, Anna E. Grzegorzewicz, Christophe Morisseau, E. Jeffrey North, Michael R. McNeil, David F. Bruhn, Tamara Hess, Jerrod S. Scarborough, Richard E. Lee, Michael S. Scherman, Lei Yang
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2587-2599
Out of the prominent global ailments, tuberculosis (TB) is still one of the leading causes of death worldwide due to infectious disease. Development of new drugs that shorten the current tuberculosis treatment time and have activity against drug resi
Autor:
Richard E. Lee, Dianqing Sun, Julian G. Hurdle, Marcus M. Maddox, Li Shen, David F. Bruhn, Manish Kumar, Robin E. B. Lee, Sudip Adhikari
Publikováno v:
The Journal of Antibiotics. 66:319-325
The natural product engelhardione is an underexplored chemotype for developing novel treatments for bacterial infections; we therefore explored this natural product scaffold for chemical diversification and structure-activity relationship studies. Ma
Autor:
Philip T. Cherian, Chelsi D. Cassilly, John J. Bowling, Mark T. Hamann, Marcus M. Maddox, Todd B. Reynolds, Richard E. Lee
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 5, p e0154932 (2016)
PLoS ONE, Vol 11, Iss 5, p e0154932 (2016)
In order to expand the repertoire of antifungal compounds a novel, high-throughput phenotypic drug screen targeting fungal phosphatidylserine (PS) synthase (Cho1p) was developed based on antagonism of the toxin papuamide A (Pap-A). Pap-A is a cyclic
Autor:
Ashit Trivedi, Bernd Meibohm, David F. Bruhn, Michael R. McNeil, Marcus M. Maddox, Michael S. Scherman, Rakesh, Dora B. Madhura, Lei Yang, Robin B. Lee, Anne J. Lenaerts, Richard E. Lee, Janet C. Gilliland, Veronica Gruppo
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:6063-6072
A series of tetracyclic nitrofuran isoxazoline anti-tuberculosis agents was designed and synthesized to improve the pharmacokinetic properties of an initial lead compound, which had potent anti-tuberculosis activity but suffered from poor solubility,