Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marcus Keatinge"'
Autor:
Marcus Keatinge, Matthew E. Gegg, Lisa Watson, Heather Mortiboys, Nan Li, Mark Dunning, Deepak Ailani, Hai Bui, Astrid van Rens, Dirk J. Lefeber, Anthony H. V. Schapira, Ryan B. MacDonald, Oliver Bandmann
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/2eda39a160ff472d9a32f0cc12287c6c
Autor:
Sarah J. Brown, Ibrahim Boussaad, Javier Jarazo, Julia C. Fitzgerald, Paul Antony, Marcus Keatinge, Janna Blechman, Jens C. Schwamborn, Rejko Krüger, Marysia Placzek, Oliver Bandmann
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Recent evidence suggests neurogenesis is on-going throughout life but the relevance of these findings for neurodegenerative disorders such as Parkinson’s disease (PD) is poorly understood. Biallelic PINK1 mutations cause early onset, Mende
Externí odkaz:
https://doaj.org/article/f403a11711ed4072a52f7d7dcbd0861e
Autor:
Adele Leggieri, Judit García-González, Jose V. Torres-Perez, William Havelange, Saeedeh Hosseinian, Aleksandra M. Mech, Marcus Keatinge, Elisabeth M. Busch-Nentwich, Caroline H. Brennan
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Ankyrin repeat and kinase domain containing 1 (ANKK1) is a member of the receptor-interacting protein serine/threonine kinase family, known to be involved in cell proliferation, differentiation and activation of transcription factors. Genetic variati
Externí odkaz:
https://doaj.org/article/d30b7eef273e45cb91265d3e056fc9c7
Autor:
Lisa Watson, Marcus Keatinge, Matthew Gegg, Qing Bai, M. Cosmin Sandulescu, Ayelet Vardi, Anthony H. Futerman, Anthony H.V. Schapira, Edward A. Burton, Oliver Bandmann
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 563-569 (2019)
Bi-allelic mutations in the glucocerebrosidase gene (GBA1) cause Gaucher's disease, the most common human lysosomal storage disease. We previously reported a marked increase in miR-155 transcript levels and early microglial activation in a zebrafish
Externí odkaz:
https://doaj.org/article/c65331c6cca44e7d96500e28a2d622ae
Autor:
Marcus Keatinge, Themistoklis M Tsarouchas, Tahimina Munir, Nicola J Porter, Juan Larraz, Davide Gianni, Hui-Hsin Tsai, Catherina G Becker, David A Lyons, Thomas Becker
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009515 (2021)
Zebrafish exhibit robust regeneration following spinal cord injury, promoted by macrophages that control post-injury inflammation. However, the mechanistic basis of how macrophages regulate regeneration is poorly understood. To address this gap in un
Externí odkaz:
https://doaj.org/article/ebb1d8e5ba6e43a49ae28bb01edfb043
Publikováno v:
Biology Open, Vol 9, Iss 5 (2020)
Understanding the molecular mechanisms that regulate secondary cell death after acute central nervous system (CNS) injury is critical for the development of effective neuroprotective drugs. Previous research has shown that neurotoxic processes includ
Externí odkaz:
https://doaj.org/article/7f44e948c8cc46c19bf28cfde338f55c
Autor:
Themistoklis M. Tsarouchas, Daniel Wehner, Leonardo Cavone, Tahimina Munir, Marcus Keatinge, Marvin Lambertus, Anna Underhill, Thomas Barrett, Elias Kassapis, Nikolay Ogryzko, Yi Feng, Tjakko J. van Ham, Thomas Becker, Catherina G. Becker
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
While proinflammatory signalling is preventive to axon regrowth, activated macrophages can be beneficial, for example by limiting the inflammation. This study uses mutant zebrafish lines that lack macrophages and/or microglia to show that peripheral
Externí odkaz:
https://doaj.org/article/81b50b2041a6448a84c8fcb25d9591a7
Publikováno v:
Biology Open, Vol 8, Iss 10 (2019)
The loss of dopaminergic neurons (DA) is a pathological hallmark of sporadic and familial forms of Parkinson's disease (PD). We have previously shown that inhibiting mitochondrial calcium uniporter (mcu) using morpholinos can rescue DA neurons in the
Externí odkaz:
https://doaj.org/article/d41f2a9893ab40b1907f2c3cd99909ca
Publikováno v:
eLife, Vol 8 (2019)
Previously we described direct cellular interactions between microglia and AKT1+ brain tumour cells in zebrafish (Chia et al., 2018). However, it was unclear how these interactions were initiated: it was also not clear if they had an impact on the gr
Externí odkaz:
https://doaj.org/article/b9c197a358d740c4b668c1a721bdd91b
Autor:
Louisa K. Drake, Marcus Keatinge, Themistoklis M. Tsarouchas, Catherina G. Becker, David A. Lyons, Thomas Becker
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630112
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::482986537cbe6b4daf37c9c59fc66e67
https://doi.org/10.1007/978-1-0716-3012-9_15
https://doi.org/10.1007/978-1-0716-3012-9_15
