Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marcus K, Giacci"'
Autor:
Nicole M. Smith, Marcus K. Giacci, Alexander Gough, Charlotte Bailey, Terence McGonigle, Anna M. B. Black, Thomas O. Clarke, Carole A. Bartlett, K. Swaminathan Iyer, Sarah A. Dunlop, Melinda Fitzgerald
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-18 (2018)
Abstract Background Following injury to the central nervous system, increased microglia, secretion of pro- and anti-inflammatory cytokines, and altered blood-brain barrier permeability, a hallmark of degeneration, are observed at and immediately adja
Externí odkaz:
https://doaj.org/article/0b49ca1779304d90a76e7d98fb19b1fa
Autor:
Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey, Melinda Fitzgerald
Publikováno v:
BMC Neuroscience, Vol 18, Iss 1, Pp 1-16 (2017)
Abstract Background Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metab
Externí odkaz:
https://doaj.org/article/1f6e5113e52a4da8841df25ed981e229
Autor:
Nathanael J Yates, Marcus K Giacci, Ryan L O'Hare Doig, Wissam Chiha, Bethany E Ashworth, Jade Kenna, Carole A Bartlett, Melinda Fitzgerald
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 2, Pp 307-316 (2017)
Studies have shown that a combined application of several ion channel inhibitors immediately after central nervous system injury can inhibit secondary degeneration. However, for clinical use, it is necessary to determine how long after injury the com
Externí odkaz:
https://doaj.org/article/342b253e6c554f1892dae1202575c069
Autor:
Marcus K Giacci, Lachlan Wheeler, Sarah Lovett, Emma Dishington, Bernadette Majda, Carole A Bartlett, Emma Thornton, Elizabeth Harford-Wright, Anna Leonard, Robert Vink, Alan R Harvey, Jan Provis, Sarah A Dunlop, Nathan S Hart, Stuart Hodgetts, Riccardo Natoli, Corinna Van Den Heuvel, Melinda Fitzgerald
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104565 (2014)
Red/near-infrared irradiation therapy (R/NIR-IT) delivered by laser or light-emitting diode (LED) has improved functional outcomes in a range of CNS injuries. However, translation of R/NIR-IT to the clinic for treatment of neurotrauma has been hamper
Externí odkaz:
https://doaj.org/article/6ea059e14c2e4654a179194797e7b1af
Autor:
Charlotte Bailey, Melinda Fitzgerald, Marcus K. Giacci, Anna M. B. Black, Alexander Gough, Carole A. Bartlett, Thomas O. Clarke, Nicole M. Smith, Sarah A. Dunlop, Terence McGonigle, K. Swaminathan Iyer
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-18 (2018)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Following injury to the central nervous system, increased microglia, secretion of pro- and anti-inflammatory cytokines, and altered blood-brain barrier permeability, a hallmark of degeneration, are observed at and immediately adjacent to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8950d613a33ea235c5e02409da06da
http://link.springer.com/article/10.1186/s12974-018-1227-0
http://link.springer.com/article/10.1186/s12974-018-1227-0
Autor:
Melinda Fitzgerald, Carole A. Bartlett, Alan R. Harvey, Stuart I. Hodgetts, Nathanael J. Yates, Ryan L. O'Hare Doig, Wissam Chiha, Nicole M. Smith, Marcus K. Giacci
Publikováno v:
BMC Neuroscience, Vol 18, Iss 1, Pp 1-16 (2017)
BMC Neuroscience
BMC Neuroscience
© 2017 The Author(s). Background: Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498aeff74b268ca616c9a52f46679ccd
http://link.springer.com/article/10.1186/s12868-017-0380-1
http://link.springer.com/article/10.1186/s12868-017-0380-1
Autor:
K. Swaminathan Iyer, Paul Guagliardo, Carole A. Bartlett, Nicole M. Smith, Melinda Fitzgerald, Marcus K. Giacci, Lillian M. Toomey, Matt R. Kilburn, Haibo Jiang
Publikováno v:
Journal of Experimental Neuroscience, Vol 12 (2018)
Journal of Experimental Neuroscience
Journal of Experimental Neuroscience
Loss of function following injury to the CNS is worsened by secondary degeneration of neurons and glia surrounding the injury and is initiated by oxidative damage. However, it is not yet known which cellular populations and structures are most vulner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4119bdb4d15c28b3f351c0750a82d176
https://pubmed.ncbi.nlm.nih.gov/29915135
https://pubmed.ncbi.nlm.nih.gov/29915135
Autor:
Melinda Fitzgerald, Marcus K. Giacci, Carole A. Bartlett, Matt R. Kilburn, Sarah A. Dunlop, Minh Huynh
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Following injury to the central nervous system, axons and myelin distinct from the initial injury site undergo changes associated with compromised function. Quantifying such changes is important to understanding the pathophysiology of neurotrauma; ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3996ca792bee0244948aa8ac6d6d01
https://doi.org/10.1038/s41598-018-22361-2
https://doi.org/10.1038/s41598-018-22361-2
Autor:
Jennifer Rodger, K. Swaminathan Iyer, Carole A. Bartlett, Greg Cozens, Ryan L. O'Hare Doig, Sarah A. Dunlop, Melinda Fitzgerald, Celeste H. Wale, Paula I. Fuller, Michael Challenor, Livia C. Hool, Marcus K. Giacci
Publikováno v:
Biochimie. 112:160-171
Glutamate excitotoxicity contributes to damage following injury to the central nervous system via mechanisms including changes in the expression of receptors, calcium overload, oxidative stress and cell death. Excitotoxicity is triggered by glutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8f074b2ffc6e5f6405672f34be6b21
https://doi.org/10.1016/j.biochi.2015.03.008
https://doi.org/10.1016/j.biochi.2015.03.008
Autor:
Hannah R, Milbourn, Lillian M, Toomey, Nikolas, Gavriel, Chloe G G, Gray, Alexander H, Gough, Brooke, Fehily, Marcus K, Giacci, Melinda, Fitzgerald
Publikováno v:
Discovery medicine. 23(129)
Following injury to the central nervous system, secondary degeneration is mediated by Ca2+ imbalances and overproduction of reactive oxygen species from mitochondria, and is associated with myelin deficits and loss of function. Preventing intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04933786df4e88e3fd575602027acb75
https://pubmed.ncbi.nlm.nih.gov/28877447
https://pubmed.ncbi.nlm.nih.gov/28877447