Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Marcus J Tindall"'
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 11, p e1004589 (2015)
We present a data-driven mathematical model of a key initiating step in platelet activation, a central process in the prevention of bleeding following Injury. In vascular disease, this process is activated inappropriately and causes thrombosis, heart
Externí odkaz:
https://doaj.org/article/2728138fd4a844f6a45d2f3be9754e18
Autor:
Marcus J Tindall, Angela Clerk
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 5, p e1003597 (2014)
Activating transcription factor 3 (Atf3) is rapidly and transiently upregulated in numerous systems, and is associated with various disease states. Atf3 is required for negative feedback regulation of other genes, but is itself subject to negative fe
Externí odkaz:
https://doaj.org/article/659ea444de014619b8b982ad42471a64
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 8 (2010)
Understanding how multiple signals are integrated in living cells to produce a balanced response is a major challenge in biology. Two-component signal transduction pathways, such as bacterial chemotaxis, comprise histidine protein kinases (HPKs) and
Externí odkaz:
https://doaj.org/article/5d5ebb4c44914ca8956fbdad176e81d9
Autor:
Nikoleta Vavouraki, James E. Tomkins, Eleanna Kara, Henry Houlden, John Hardy, Marcus J. Tindall, Patrick A. Lewis, Claudia Manzoni
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102484- (2021)
Summary: The Hereditary Spastic Paraplegias are a group of neurodegenerative diseases characterized by spasticity and weakness in the lower body. Owing to the combination of genetic diversity and variable clinical presentation, the Hereditary Spastic
Externí odkaz:
https://doaj.org/article/28e4847168b144048b55401487676d3f
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 528-538 (2015)
We formulate an agent-based population model of Escherichia coli cells which incorporates a description of the chemotaxis signalling cascade at the single cell scale. The model is used to gain insight into the link between the signalling cascade dyna
Externí odkaz:
https://doaj.org/article/acfa2c2887294388bc0aecbe418f1b40
Autor:
Josie Dodd, Peter K. Sweby, Sean Mayes, Erik H. Murchie, Asha S. Karunaratne, Festo Massawe, Marcus J. Tindall
Publikováno v:
Journal of theoretical biology. 560
A principal objective in agriculture is to maximise food production; this is particularly relevant with the added demands of an ever increasing population, coupled with the unpredictability that climate change brings. Further improvements in producti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83c6ac24f6a887992448017e8656e41
https://pubmed.ncbi.nlm.nih.gov/36509139
https://pubmed.ncbi.nlm.nih.gov/36509139
Autor:
Julie A. Lovegrove, Amanda J. Unsworth, Parvathy Sasikumar, Alexander R. Stainer, Alexander P. Bye, Marcus J. Tindall, Lisa M. Holbrook, Jonathan M. Gibbins
Publikováno v:
TH Open, Vol 03, Iss 03, Pp e244-e258 (2019)
TH Open: Companion Journal to Thrombosis and Haemostasis
TH Open: Companion Journal to Thrombosis and Haemostasis
Quercetin, a dietary flavonoid, has been reported to possess antiplatelet activity. However, its extensive metabolism following ingestion has resulted in difficulty elucidating precise mechanisms of action. In this study, we aimed to characterize the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd389f9afdf9f89857140395848e8e04
https://doi.org/10.1055/s-0039-1694028
https://doi.org/10.1055/s-0039-1694028
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
The phosphatidylinositol (PI) cycle is central to eukaryotic cell signaling. Its complexity, due to the number of reactions and lipid and inositol phosphate intermediates involved makes it difficult to analyze experimentally. Computational modelling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6183a214c54fdc2efff69991a8d76ed1
http://europepmc.org/articles/PMC7414024
http://europepmc.org/articles/PMC7414024
Publikováno v:
Journal of Theoretical Biology. 443:157-176
We formulate, parameterise and analyse a mathematical model of the mevalonate pathway, a key pathway in the synthesis of cholesterol. Of high clinical importance, the pathway incorporates rate limiting enzymatic reactions with multiple negative feedb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9cf5f31958f5ebf7cee957336e2e000
https://doi.org/10.1016/j.jtbi.2017.12.023
https://doi.org/10.1016/j.jtbi.2017.12.023
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 45:537-555
In this paper we present a framework for the reduction and linking of physiologically based pharmacokinetic (PBPK) models with models of systems biology to describe the effects of drug administration across multiple scales. To address the issue of mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d40527da9f1c34aba4fd9959c2b0a72
https://doi.org/10.1007/s10928-018-9584-y
https://doi.org/10.1007/s10928-018-9584-y