Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Marcus J Robinson"'
Autor:
Zhiyong Yang, Marcus J Robinson, Xiangjun Chen, Geoffrey A Smith, Jack Taunton, Wanli Liu, Christopher D C Allen
Publikováno v:
eLife, Vol 5 (2016)
IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR). In the absence of cognate antigen, t
Externí odkaz:
https://doaj.org/article/052ba008c0614c7daaf4f9ccd0db8325
Autor:
Dimitra Zotos, Isaak Quast, Connie S. N. Li-Wai-Suen, Craig I. McKenzie, Marcus J. Robinson, Andrey Kan, Gordon K. Smyth, Philip D. Hodgkin, David M. Tarlinton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
How IL-21 functions during development of high affinity antibody in germinal centres (GC) is not fully known. Here using a cell cycle reporter mouse, the authors show that IL-21 promotes cell cycle progression within the GC light zone and enables rel
Externí odkaz:
https://doaj.org/article/bac1ae196b49479fb1cf299b4526a9d7
Autor:
Rishabh Sharma, Akram Zamani, Larissa K. Dill, Mujun Sun, Erskine Chu, Marcus J. Robinson, Terence J. O’Brien, Sandy R. Shultz, Bridgette D. Semple
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-23 (2021)
Abstract Background Traumatic brain injury (TBI) is a major cause of disability in young children, yet the factors contributing to poor outcomes in this population are not well understood. TBI patients are highly susceptible to nosocomial infections,
Externí odkaz:
https://doaj.org/article/98764a653f6e40819232671f83a70582
Autor:
Zhoujie Ding, Isaak Quast, Feng Yan, Yang Liao, Catherine Pitt, Kristy O‐Donnell, Marcus J Robinson, Wei Shi, Axel Kallies, Dimitra Zotos, David M Tarlinton
Publikováno v:
Immunology and cell biologyREFERENCES. 100(9)
Aberrant expression of the proto-oncogene BCL6 is a driver of tumorigenesis in diffuse large B cell lymphoma (DLBCL). Mice overexpressing BCL6 from the B cell-specific immunoglobulin heavy chain μ intron promoter (Iμ-Bcl6supTg/+/sup) develop B cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c727ee6aabdbd68f962e1d2c22cddeb1
https://pubmed.ncbi.nlm.nih.gov/35916066
https://pubmed.ncbi.nlm.nih.gov/35916066
Autor:
Alexandra R Dvorscek, Craig I McKenzie, Marcus J Robinson, Zhoujie Ding, Catherine Pitt, Kristy O'Donnell, Dimitra Zotos, Robert Brink, David M Tarlinton, Isaak Quast
Publikováno v:
EMBO reports. 23
The proliferation and differentiation of antigen-specific B cells, including the generation of germinal centers (GC), are prerequisites for long-lasting, antibody-mediated immune protection. Affinity for antigen determines B cell recruitment, prolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440dba50bef9d75f935f4d4e4c8ee7a7
https://doi.org/10.15252/embr.202254677
https://doi.org/10.15252/embr.202254677
Publikováno v:
Immunological Reviews. 296:87-103
Plasma cells (PC) are key to protective immunity because they secrete antibodies. Surviving for periods ranging from days to decades in mammals, PC possess varying survival times that cannot be entirely stochastic or extrinsically set, as presumed ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8730cd26154038c69c69d7d39da03c18
https://doi.org/10.1111/imr.12895
https://doi.org/10.1111/imr.12895
Autor:
Alexandra R. Dvorscek, Craig I. McKenzie, Marcus J. Robinson, Zhoujie Ding, Catherine Pitt, Kristy O’Donnell, Dimitra Zotos, Robert Brink, David M. Tarlinton, Isaak Quast
The proliferation and differentiation of antigen-specific B cells, including the generation of germinal centers (GC), are prerequisites for long-lasting, high-affinity antibody-mediated immune protection. Affinity for antigen determines B cell recrui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e30cdf122b624b90ebb59838e2ef1740
https://doi.org/10.1101/2022.01.21.476732
https://doi.org/10.1101/2022.01.21.476732
Autor:
Marcus J. Robinson, Nicola L. Harris
Publikováno v:
Immunity. 53:702-704
Summary The contribution of the immunoglobulin E (IgE)-mast cell response to allergy portrays the axis as a villain with malicious intent. A new study from Starkl et al. tells a different story, highlighting a more worthwhile purpose of protecting us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb0995421a21cc366abb1548a394018
https://doi.org/10.1016/j.immuni.2020.09.012
https://doi.org/10.1016/j.immuni.2020.09.012
Autor:
David M. Tarlinton, Kristy O'Donnell, Catherine Pitt, Lars Nitschke, Sarah A. Jones, Marcus J. Robinson, Anika M Valk, Erica J. Brodie
Publikováno v:
Immunology & Cell Biology. 97:826-839
A B cell culture system using BAFF, IL-4 and IL-21 was recently developed that generates B cells with phenotypic and functional characteristics of in vivo-generated germinal center (GC) B cells. Here, we observe discrete influences of each exogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27caee856add5fa0a47ac89eee335d18
https://doi.org/10.1111/imcb.12283
https://doi.org/10.1111/imcb.12283
Publikováno v:
Nature Immunology. 22:673-674
B cells rewire complement for optimal germinal center responses. When B cell C3 activity is limited, germinal centers collapse and outputs are impaired.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a939d890aae908a90de00f873fa9478d
https://doi.org/10.1038/s41590-021-00946-w
https://doi.org/10.1038/s41590-021-00946-w