Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Marcus J Miller"'
Autor:
Ricardo A Cordova, Jagannath Misra, Parth H Amin, Anglea J Klunk, Nur P Damayanti, Kenneth R Carlson, Andrew J Elmendorf, Hyeong-Geug Kim, Emily T Mirek, Bennet D Elzey, Marcus J Miller, X Charlie Dong, Liang Cheng, Tracy G Anthony, Roberto Pili, Ronald C Wek, Kirk A Staschke
Publikováno v:
eLife, Vol 11 (2022)
A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa). Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive a
Externí odkaz:
https://doaj.org/article/0e190e2bb8b949968cf1c2d48ee6413b
Autor:
Lillian R Thistlethwaite, Varduhi Petrosyan, Xiqi Li, Marcus J Miller, Sarah H Elsea, Aleksandar Milosavljevic
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009551 (2021)
[This corrects the article DOI: 10.1371/journal.pcbi.1008550.].
Externí odkaz:
https://doaj.org/article/3dec0ed6bd2240e5b8f62f4d01beacb4
Autor:
Lillian R Thistlethwaite, Varduhi Petrosyan, Xiqi Li, Marcus J Miller, Sarah H Elsea, Aleksandar Milosavljevic
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 1, p e1008550 (2021)
We consider the following general family of algorithmic problems that arises in transcriptomics, metabolomics and other fields: given a weighted graph G and a subset of its nodes S, find subsets of S that show significant connectedness within G. A sp
Externí odkaz:
https://doaj.org/article/d8935c88ca1248f9bd4404aed5f9f659
Autor:
Shuk Ching, Chong, Ye, Cao, Eva L W, Fung, Soledad, Kleppe, Karen W, Gripp, Jozef, Hertecant, Ayman W, El-Hattab, Jehan, Suleiman, Gary, Clark, Gretchen, von Allmen, Olga, Rodziyevska, Richard A, Lewis, Jill A, Rosenfeld, Jie, Dong, Xia, Wang, Marcus J, Miller, Weimin, Bi, Pengfei, Liu, Fernando, Scaglia
Publikováno v:
American Journal of Medical Genetics Part A. 191:776-785
WWOX biallelic loss-of-function pathogenic single nucleotide variants (SNVs) and copy number variants (CNVs) including exonic deletions and duplications cause WWOX-related epileptic encephalopathy (WOREE) syndrome. This disorder is characterized by r
Autor:
Ricardo Cordova, Jagannath Misra, Parth H. Amin, Nur P. Damayanti, Kenneth R. Carlson, Angela J. Klunk, Emily T. Mirek, Marcus J. Miller, Tracy G. Anthony, Roberto Pili, Ronald C. Wek, Kirk A. Staschke
Publikováno v:
The FASEB Journal. 36
Autor:
Lillian R. Thistlethwaite, Xiqi Li, Lindsay C. Burrage, Kevin Riehle, Joseph G. Hacia, Nancy Braverman, Michael F. Wangler, Marcus J. Miller, Sarah H. Elsea, Aleksandar Milosavljevic
Publikováno v:
Scientific Reports. 12
Untargeted metabolomics is a global molecular profiling technology that can be used to screen for inborn errors of metabolism (IEMs). Metabolite perturbations are evaluated based on current knowledge of specific metabolic pathway deficiencies, a manu
Autor:
William J. Craigen, Brett H. Graham, Sarah H. Elsea, Brendan Lee, Sandesh C.S. Nagamani, Lillian R. Thistlethwaite, Qin Sun, Adam D. Kennedy, V. Reid Sutton, Aleksandar Milosavljevic, Bridget M. Stroup, Fernando Scaglia, Marcus J. Miller, Lindsay C. Burrage
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics
Purpose: Untargeted metabolomic analysis is increasingly being used in the screening and management of individuals with inborn errors of metabolism (IEM). We aimed to test whether untargeted metabolomic analysis in plasma might be useful for monitori
Autor:
Ricardo Cordova, Jagannath Misra, Nur P. Damayanti, Parth H. Amin, Kenneth R. Carlson, Angela J. Klunk, Emily T. Mirek, Marcus J. Miller, Tracy G. Anthony, Roberto Pili, Ronald C. Wek, Kirk A. Staschke
Publikováno v:
Cancer Research. 82:3040-3040
The Integrated Stress Response (ISR) is central for adaptation and survival of tumor cells in response to exogenous and endogenous stresses. The ISR features a family of protein kinases that phosphorylate the eukaryotic translation initiation factor
Publikováno v:
Clinical chemistry. 67(11)
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics. 23(2)
Acylcarnitine analysis is a useful test for identifying patients with inborn errors of mitochondrial fatty acid β-oxidation and certain organic acidemias. Plasma is routinely used in the diagnostic workup of symptomatic patients. Urine analysis of t