Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marcus Holschbach"'
Autor:
Roberta Cologni, Marcus Holschbach, Daniela Schneider, Dirk Bier, Annette Schulze, Carina Stegmayr, Heike Endepols, Johannes Ermert, Felix Neumaier, Bernd Neumaier
Publikováno v:
Molecules, Vol 29, Iss 16, p 3939 (2024)
Mutations of isocitrate dehydrogenase 1 (IDH1) are key biomarkers for glioma classification, but current methods for detection of mutated IDH1 (mIDH1) require invasive tissue sampling and cannot be used for longitudinal studies. Positron emission tom
Externí odkaz:
https://doaj.org/article/2d3f01074a8f4d80b35dfdde0eee8892
Autor:
Swen Humpert, Daniela Schneider, Markus Lang, Annette Schulze, Felix Neumaier, Marcus Holschbach, Dirk Bier, Bernd Neumaier
Publikováno v:
Molecules, Vol 29, Iss 5, p 1089 (2024)
Tozadenant (4-hydroxy-N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-4-methylpiperidine-1-carboxamide) is a highly selective adenosine A2A receptor (A2AR) antagonist and a promising lead structure for the development of A2AR-selective positron emissi
Externí odkaz:
https://doaj.org/article/13659766cc3a4cf2ae1b446a114dad6e
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 277 (2021)
Tracer development for positron emission tomography (PET) requires thorough evaluation of pharmacokinetics, metabolism, and dosimetry of candidate radioligands in preclinical animal studies. Since variations in pharmacokinetics and metabolism of a co
Externí odkaz:
https://doaj.org/article/7ca1f86d902d4a2585429746c68678a2
Autor:
Daniela Schneider, Angela Oskamp, Marcus Holschbach, Bernd Neumaier, Andreas Bauer, Dirk Bier
Publikováno v:
Pharmaceuticals, Vol 12, Iss 2, p 57 (2019)
The prediction of in vivo clearance from in vitro metabolism models such as liver microsomes is an established procedure in drug discovery. The potentials and limitations of this approach have been extensively evaluated in the pharmaceutical sector;
Externí odkaz:
https://doaj.org/article/02ff415f50114e79a529e8148509d044
Autor:
Daniela Schneider, Annette Schulze, Swen Humpert, Marcus Holschbach, Dirk Bier, Bernd Neumaier
Publikováno v:
Nuclear Medicine and Biology. :S102-S103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86a0ad717b64ce96491d8052f3afe9d
https://doi.org/10.1016/s0969-8051(22)00233-5
https://doi.org/10.1016/s0969-8051(22)00233-5
Autor:
Marcus Holschbach, Swen Humpert, Daniela Schneider, Annette Schulze, Dirk Bier, Bernd Neumaier
Publikováno v:
Nuclear Medicine and Biology. :S26-S27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bbf24e69f336fa26f2dfd465d8d1c86
https://doi.org/10.1016/s0969-8051(22)00096-8
https://doi.org/10.1016/s0969-8051(22)00096-8
Autor:
Dana R, Renk, Marcel, Skraban, Dirk, Bier, Annette, Schulze, Erika, Wabbals, Franziska, Wedekind, Felix, Neumaier, Bernd, Neumaier, Marcus, Holschbach
Publikováno v:
European journal of medicinal chemistry. 214
With the aim to obtain potent adenosine A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::333692951d24ccd435acf6f58577a219
https://pubmed.ncbi.nlm.nih.gov/33548636
https://pubmed.ncbi.nlm.nih.gov/33548636
Publikováno v:
Assay and drug development technologies. 18(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e7d38a763a485aa4cf7c12036867986
https://pubmed.ncbi.nlm.nih.gov/32749852
https://pubmed.ncbi.nlm.nih.gov/32749852
Autor:
Daniela, Schneider, Angela, Oskamp, Marcus, Holschbach, Bernd, Neumaier, Dirk, Bier, Andreas, Bauer
Publikováno v:
Nuclear medicine and biology.
The suitability of novel positron emission tomography (PET) radioligands for quantitative in vivo imaging is affected by various physicochemical and pharmacological parameters. In this study, the combined effect of binding affinity, lipophilicity, pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85e41c167fb17a6c8a6c291347e8bcd8
https://pubmed.ncbi.nlm.nih.gov/31838339
https://pubmed.ncbi.nlm.nih.gov/31838339
Publikováno v:
Journal of pharmacological and toxicological methods. 95
In vitro metabolism models such as liver microsomes represent an important tool for the development of novel radioligands. Comparability and physiological relevance of in vitro metabolism data critically depend on the careful evaluation and optimizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9fb6a681fe31157a9742f0b35b36d7fa
https://pubmed.ncbi.nlm.nih.gov/30476620
https://pubmed.ncbi.nlm.nih.gov/30476620