Výsledky vyhledávání - "Marcus Ho Yin Wong"

Akademický článek

Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli

Autor: Miaomiao Wang, Edward Wai Chi Chan, Yingkun Wan, Marcus Ho-yin Wong, Sheng Chen

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)

The proton motive force (PMF) is a critical electrochemical gradient involved in bacterial energy metabolism. Here, Miaomiao Wang, Edward Wai Chi Chan et al. demonstrate that the PMF plays a key role in starvation-induced antibiotic tolerance in E. c

Externí odkaz: https://doaj.org/article/8414b54986c941f29ad265435e846442

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Akademický článek

Transcriptional Regulation and Functional Characterization of the Plasmid-Borne oqxAB Genes in Salmonella Typhimurium

Autor: Bill Kwan-wai Chan, Marcus Ho-yin Wong, Edward Wai-chi Chan, Sheng Chen

Publikováno v: Microbiology Spectrum, Vol 10, Iss 2 (2022)

ABSTRACT Coexistence of oqxAB and aac(6′)-Ib-cr is often associated with the expression of fluoroquinolone resistance in Salmonella. The actual role of the plasmid-borne oqxAB gene and its regulatory mechanism compared to its chromosomally encoded

Externí odkaz: https://doaj.org/article/d45ebf4338364a888873b00053ed3829

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Akademický článek

Over-Expression of ISAba1-Linked Intrinsic and Exogenously Acquired OXA Type Carbapenem-Hydrolyzing-Class D-ß-Lactamase-Encoding Genes Is Key Mechanism Underlying Carbapenem Resistance in Acinetobacter baumannii

Autor: Marcus Ho-yin Wong, Bill Kwan-wai Chan, Edward Wai-chi Chan, Sheng Chen

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)

Acinetobacter baumannii is an important clinical pathogen which often causes fatal infections among seriously ill patients. Treatment options for managing infections caused by this organism have become limited as a result of emergence of carbapenem r

Externí odkaz: https://doaj.org/article/daa6a17f683a4c7abf00fe8c88256c7e

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Akademický článek

Complete Sequence of a F33:A-:B- Conjugative Plasmid Carrying the oqxAB, fosA3 and blaCTX-M-55 Elements from a Foodborne Escherichia coli Strain

Autor: Marcus Ho-yin Wong, Miaomiao Xie, Liqi Xie, Dachuan Lin, Ruichao Li, Yuanjie Zhou, Edward Wai-Chi Chan, Sheng Chen

Publikováno v: Frontiers in Microbiology, Vol 7 (2016)

This study reports the complete sequence of pE80, a conjugative IncFII plasmid recovered from an E. coli strain isolated from chicken meat. This plasmid harbors multiple resistance determinants including oqxAB, fosA3, blaCTX-M-55 and blaTEM-1, and is

Externí odkaz: https://doaj.org/article/02b86e3902c54bb78c7a628641195ed1

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Structural and Functional Characterization of OXA-48: Insight into Mechanism and Structural Basis of Substrate Recognition and Specificity

Autor: Qipeng Cheng, Edward Wai-Chi Chan, Sheng Chen, Marcus Ho Yin Wong, Perry Tim-Fat Shum, Jiachi Chiou

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11480, p 11480 (2021)

Class D β-lactamase OXA-48 is widely distributed among Gram-negative bacteria and is an important determinant of resistance to the last-resort carbapenems. Nevertheless, the detailed mechanism by which this β-lactamase hydrolyzes its substrates rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b30bf6bfd6cc7b72048425fb29b0a6a
http://europepmc.org/articles/PMC8583920

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Akademický článek

Functional categorization of carbapenemase-mediated resistance by a combined genotyping and two-tiered Modified Hodge Test approach

Autor: Marcus Ho-yin Wong, Yi eLi, Edward Wai-chi eChan, Sheng eChen

Publikováno v: Frontiers in Microbiology, Vol 6 (2015)

The functional relationship between carbapenemase production and phenotypic resistance in Gram negative bacterial pathogens is often ill-defined. To address this issue, we developed a two-tiered Modified Hodge Test (MHT) approach for carbapenemase de

Externí odkaz: https://doaj.org/article/bcacd83e964f4ab1adcaac98149874bb

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Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli

Autor: Edward Chan, Marcus Ho Yin Wong, Miaomiao Wang, Sheng Chen, Yingkun Wan

Publikováno v: Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)

Recent evidence suggests that metabolic shutdown alone does not fully explain how bacteria exhibit phenotypic antibiotic tolerance. In an attempt to investigate the range of starvation-induced physiological responses underlying tolerance development,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb6c58a7f936a2950f5cf97763986a6
https://pubmed.ncbi.nlm.nih.gov/34521984

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Autor: Sheng Chen, Edward Wai-Chi Chan, Bill Kwan-wai Chan, Marcus Ho Yin Wong

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)
Frontiers in Microbiology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd94e4c84bc19d17ae77442018ca1304
https://www.frontiersin.org/article/10.3389/fmicb.2019.02809/full

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IS26-mediated formation of a virulence and resistance plasmid in Salmonella Enteritidis

Autor: Sheng Chen, Edward Wai-Chi Chan, Marcus Ho Yin Wong

Publikováno v: Journal of Antimicrobial Chemotherapy. 72:2750-2754

Objectives To characterize a novel virulence-resistance plasmid pSE380T carried by a Salmonella enterica serotype Enteritidis clinical strain SE380. Methods The plasmid pSE380T was conjugated to Escherichia coli strain J53 and sequenced by PacBio RSI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28b79852f2454bb8f017d99a47e8262
https://doi.org/10.1093/jac/dkx238

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