Zobrazeno 1 - 10
of 340
pro vyhledávání: '"Marcus Ho"'
Autor:
Marcus Ho-Hin Shum, Yang Lee, Leighton Tam, Hui Xia, Oscar Lung-Wa Chung, Zhihong Guo, Tommy Tsan-Yuk Lam
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 759-770 (2024)
Coronaviruses (CoVs) pose a major risk to global public health due to their ability to infect diverse animal species and potential for emergence in humans. The CoV spike protein mediates viral entry into the cell and plays a crucial role in determini
Externí odkaz:
https://doaj.org/article/1d830b35b6564d84b59bc45186de6796
Autor:
Yao Pei, Marcus Ho-Hin Shum, Yunshi Liao, Vivian W. Leung, Yu-Nong Gong, David K. Smith, Xiaole Yin, Yi Guan, Ruibang Luo, Tong Zhang, Tommy Tsan-Yuk Lam
Publikováno v:
Microbiome, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Background Emergence of antibiotic resistance in bacteria is an important threat to global health. Antibiotic resistance genes (ARGs) are some of the key components to define bacterial resistance and their spread in different environments. I
Externí odkaz:
https://doaj.org/article/283e43a09b854be08429e25a8b858cf0
Autor:
Wing-Gi Wu, Marcus Ho-Hin Shum, Ivan Tak-Fai Wong, Kelvin Keru Lu, Lam-Kwong Lee, Jake Siu-Lun Leung, Hiu-Yin Lao, Annie Wing-Tung Lee, Pak-Ting Hau, Chloe Toi-Mei Chan, Harmen Fung-Tin Wong, Sharon Ka-Yee Fung, Sally Choi-Ying Wong, Iain Chi-Fung Ng, Timothy Ting-Leung Ng, Ning Chow, Alex Yat-Man Ho, Mei Fan Hung, Franklin Wang-Ngai Chow, Maureen Mo-Lin Wong, Wing-Kin To, Tommy Tsan-Yuk Lam, Kristine Shik Luk, Gilman Kit-Hang Siu
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
ABSTRACTBetween January 2015 and October 2022, 38 patients with culture-confirmed melioidosis were identified in the Kowloon West (KW) Region, Hong Kong. Notably, 30 of them were clustered in the Sham Shui Po (SSP) district, which covers an estimated
Externí odkaz:
https://doaj.org/article/c3a8a233eced457a8aaf656ab19f7432
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
The proton motive force (PMF) is a critical electrochemical gradient involved in bacterial energy metabolism. Here, Miaomiao Wang, Edward Wai Chi Chan et al. demonstrate that the PMF plays a key role in starvation-induced antibiotic tolerance in E. c
Externí odkaz:
https://doaj.org/article/8414b54986c941f29ad265435e846442
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Coexistence of oqxAB and aac(6′)-Ib-cr is often associated with the expression of fluoroquinolone resistance in Salmonella. The actual role of the plasmid-borne oqxAB gene and its regulatory mechanism compared to its chromosomally encoded
Externí odkaz:
https://doaj.org/article/d45ebf4338364a888873b00053ed3829
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Acinetobacter baumannii is an important clinical pathogen which often causes fatal infections among seriously ill patients. Treatment options for managing infections caused by this organism have become limited as a result of emergence of carbapenem r
Externí odkaz:
https://doaj.org/article/daa6a17f683a4c7abf00fe8c88256c7e
Autor:
Jiachi Chiou, Qipeng Cheng, Perry Tim-fat Shum, Marcus Ho-yin Wong, Edward Wai-chi Chan, Sheng Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11480 (2021)
Class D β-lactamase OXA-48 is widely distributed among Gram-negative bacteria and is an important determinant of resistance to the last-resort carbapenems. Nevertheless, the detailed mechanism by which this β-lactamase hydrolyzes its substrates rem
Externí odkaz:
https://doaj.org/article/f47b3272ce3a49a29acb1e096c33c58c
Autor:
Marcus Ho-yin Wong, Miaomiao Xie, Liqi Xie, Dachuan Lin, Ruichao Li, Yuanjie Zhou, Edward Wai-Chi Chan, Sheng Chen
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
This study reports the complete sequence of pE80, a conjugative IncFII plasmid recovered from an E. coli strain isolated from chicken meat. This plasmid harbors multiple resistance determinants including oqxAB, fosA3, blaCTX-M-55 and blaTEM-1, and is
Externí odkaz:
https://doaj.org/article/02b86e3902c54bb78c7a628641195ed1
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
The functional relationship between carbapenemase production and phenotypic resistance in Gram negative bacterial pathogens is often ill-defined. To address this issue, we developed a two-tiered Modified Hodge Test (MHT) approach for carbapenemase de
Externí odkaz:
https://doaj.org/article/bcacd83e964f4ab1adcaac98149874bb
Publikováno v:
Frontiers in Microbiology, Vol 5 (2014)
Emergence of multidrug-resistant S. Typhimurium strains, especially the ACSSuT and nalidixic acid R types, has significantly compromised the effectiveness of current strategies to control Salmonella infections, resulting in increased morbidity and mo
Externí odkaz:
https://doaj.org/article/29240090b8324efeb6c5f0dae59737f4