Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Marcus Henze"'
Autor:
Marcus Henze, Weikang Ma, Robert L. Anderson, Thomas C. Irving, Henry M Gong, Carlos del Rio, Fiona L. Wong
Publikováno v:
Circ Res
Rationale: Myofilament length-dependent activation (LDA) is the key underlying mechanism of cardiac heterometric autoregulation, commonly referred as the Frank-Starling Law of the heart. Although alterations in LDA are common in cardiomyopathic state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1785ed3784635bef90db962eca02fc
https://doi.org/10.1161/circresaha.120.318647
https://doi.org/10.1161/circresaha.120.318647
Autor:
Cynthia Kelly, Robert E. Anderson, Pierpaolo Pellicori, Jean François Tamby, Scott D. Solomon, Chun Yang, Frank Wagner, Albert Camacho, Michael J. Koren, Gregory Kurio, Henk P. Swart, Narayana Prasad, Carlos L. del Rio, Wanying Li, Kate Wells, Leslie B. Forgosh, Dinesh Gupta, Ray E. Hershberger, Marcus Henze, Lars H. Lund, Anu R. Anto, Fang Liang, Kaylyn M Bell, Sam L. Teichman, Ravi Karra, Adriaan A. Voors, John G.F. Cleland, Jay M. Edelberg
Publikováno v:
European Journal of Heart Failure, 22(9), 1649-1658. Wiley
Aims: Both left ventricular (LV) and left atrial (LA) dysfunction and remodelling contribute to adverse outcomes in heart failure with reduced ejection fraction (HFrEF). Danicamtiv is a novel, cardiac myosin activator that enhances cardiomyocyte cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3225ff9e849b78ed61b5bab3904271fd
https://doi.org/10.1002/ejhf.1933
https://doi.org/10.1002/ejhf.1933
Autor:
Marcus Henze, Sheerin Luis Shahidi-Latham, Emily Hollenbeck, Trisha Smit, Daniel Chin, Carlos del Rio, Frank Rohret, Kaylyn M Bell, David M. Ryba
Publikováno v:
Circulation. 142
Introduction: Hypertrophic cardiomyopathy (HCM) is a progressive disease characterized by cardiac remodeling, impaired relaxation, left-atrial enlargement, and exertional intolerance. Direct myosin-inhibition with mavacamten can normalize contractili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c8575107d6f9fd88679de5eacb6df04
https://doi.org/10.1161/circ.142.suppl_3.17492
https://doi.org/10.1161/circ.142.suppl_3.17492
Publikováno v:
European Heart Journal. 41
B: Alterations in the length dependent activation (LDA) of left ventricular (LV) muscle fibres, the mechanistic driver of the Frank-Starling Law of the heart, are thought to mediate impaired LV function in heart failure (HF). However, little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::638b5588ff5d5b24b1af2122429304da
https://doi.org/10.1093/ehjci/ehaa946.3681
https://doi.org/10.1093/ehjci/ehaa946.3681
Autor:
Chehade N. Karam, E. Douglas Lewandowski, R. John Solaro, Marcus Henze, Natasha H. Banke, Chad M. Warren
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 312:H681-H690
Although alterations in fatty acid (FA) metabolism have been shown to have a negative impact on contractility of the hypertrophied heart, the targets of action remain elusive. In this study we compared the function of skinned fiber bundles from trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8218fe2f6efed24106084f16ffecb15
https://doi.org/10.1152/ajpheart.00469.2016
https://doi.org/10.1152/ajpheart.00469.2016
Abstract 905: Length Dependent Activation in Porcine Cardiac Myofilaments is Modulated by Mavacamten
Autor:
Thomas C. Irving, Marcus Henze, Robert E. Anderson, Weikang Ma, Carlos del Rio, Henry Gong, Fiona K. Wong
Publikováno v:
Circulation Research. 125
Length dependent activation (LDA) is a property of muscle where increased sarcomere length (SL) leads to increased force of contraction. Despite its key role in both normal and pathological states, the molecular mechanisms underlying LDA are not unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aa9a58ca8c5b61cad506d7015a35f85
https://doi.org/10.1161/res.125.suppl_1.905
https://doi.org/10.1161/res.125.suppl_1.905
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Autor:
Joshua M. Gorham, Yonghong Song, Johan D. Oslob, Christine E. Seidman, Brooke C. Harrison, Jonathan G. Seidman, Marc J. Evanchik, Robert S. McDowell, Robert L. Anderson, Leslie A. Leinwand, James A. Spudich, Hiroko Wakimoto, William Wan, Hector M. Rodriguez, Eric M. Green, Marcus Henze, Raja Kawas
Publikováno v:
Science. 351:617-621
Powering down yields a healthier heart In hypertrophic cardiomyopathy (HCM), the heart muscle enlarges and becomes progressively less efficient at pumping blood. HCM can be caused by mutations in components of the sarcomere (the heart's contractile u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::083171b2cba9f40812b6ab83a575051d
https://doi.org/10.1126/science.aad3456
https://doi.org/10.1126/science.aad3456
Autor:
Brian S. Ferguson, Steven Tobia, Carlos del Rio, Marcus Henze, Christopher Zambataro, Rafael Shimkunas
Publikováno v:
Journal of Molecular and Cellular Cardiology. 140:44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48263a2f10843e8d1ae0411bf8f73a20
https://doi.org/10.1016/j.yjmcc.2019.11.105
https://doi.org/10.1016/j.yjmcc.2019.11.105
Autor:
Thomas C. Irving, Makenna M. Morck, Fiona L. Wong, Joshua M. Gorham, Henry Gong, Robert L. Anderson, Darshan V. Trivedi, Roger Cooke, Kathleen M. Ruppel, Christopher S. Rogers, Jonathan G. Seidman, Marcus Henze, James A. Spudich, Weikang Ma, Eric M. Green, Saswata S. Sarkar
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However, measurements of the intrinsic force, velocity, and ATPase activity of myosin have not provided a cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d4fe093fdbae284c3bc9c3e678cb10
https://doi.org/10.1073/pnas.1809540115
https://doi.org/10.1073/pnas.1809540115
Autor:
Heather Bogie, Marcus Henze, John Yucel, Sarah Fernandes, Brain Ferguson, Marc J. Evanchik, Carlos L Rio, Christopher Zambataro
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf29b3388e4c49ba4e2aec34f96bb60e
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb335
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb335