Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Marcus Gerlach"'
Autor:
Maike Roas, Binje Vick, Marc-André Kasper, Marina Able, Harald Polzer, Marcus Gerlach, Elisabeth Kremmer, Judith S. Hecker, Saskia Schmitt, Andreas Stengl, Verena Waller, Natascha Hohmann, Moreno Festini, Alexander Ludwig, Lisa Rohrbacher, Tobias Herold, Marion Subklewe, Katharina S. Götze, Christian P. R. Hackenberger, Dominik Schumacher, Jonas Helma-Smets, Irmela Jeremias, Heinrich Leonhardt, Karsten Spiekermann
Publikováno v:
Blood 141, 1023-1035 (2023)
Fms-like tyrosine kinase 3 (FLT3) is often overexpressed or constitutively activated by internal tandem duplication (ITD) and tyrosine kinase domain (TKD) mutations in acute myeloid leukemia (AML). Despite the use of receptor tyrosine kinase inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c6fed23aea58bf52bec340f98802a9
https://pubmed.ncbi.nlm.nih.gov/35981498
https://pubmed.ncbi.nlm.nih.gov/35981498
Autor:
Ksenia Kolobynina, Christian P. R. Hackenberger, Heinrich Leonhardt, Jonathan Schwach, Katharina Brandstetter, Hartmann Harz, Philipp Ochtrop, M. Cristina Cardoso, Marcus Gerlach, Andreas Stengl, Jonas Helma
Publikováno v:
Chembiochem
Antibody conjugates have taken a great leap forward as tools in basic and applied molecular life sciences that was enabled by the development of chemoselective reactions for the site‐specific modification of proteins. Antibody‐oligonucleotide con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f27dd6f68b0c0052f4a0ccd141dc58
https://doi.org/10.1002/cbic.202000727
https://doi.org/10.1002/cbic.202000727
Autor:
Marcus Gerlach, Saskia Schmitt, Philipp Cyprys, Marc-André Kasper, Isabelle Mai, Maarten H. Vermeer, Steven M. Horwitz, Guenter R Fingerle-Rowson, Annette Vogl, Dominik Schumacher, Jonas Helma-Smets
Publikováno v:
Blood. 140:9397-9398
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9511bd0cd68d6d95b5e9fac28f44ee44
https://doi.org/10.1182/blood-2022-158681
https://doi.org/10.1182/blood-2022-158681
Autor:
Marcus Gerlach, Anselm F. L. Schneider, Dominik Schumacher, Marc-André Kasper, Jonas Helma, Christian P. R. Hackenberger, Stefanie Boldt, Heinrich Leonhardt, Mathias Christmann, Philipp Ochtrop, Christiane Groneberg
Publikováno v:
Chembiochem
Herein, the application of N‐hydroxysuccinimide‐modified phosphonamidate building blocks for the incorporation of cysteine‐selective ethynylphosphonamidates into lysine residues of proteins, followed by thiol addition with small molecules and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54dfa7c81315bdd6ecb44f243d35d28a
https://doi.org/10.1002/cbic.201900587
https://doi.org/10.1002/cbic.201900587
Autor:
Georg Falck, Kristian M. Müller, Tobias Krüger, Thomas Dierks, Norbert Sewald, Mareile Boschanski, Benjamin Müller, Lennard Karsten, Marcus Gerlach, Sarfaraz Alam
Publikováno v:
Bioconjugate chemistry. 32(6)
Multiple, site-specific protein conjugation is increasingly attractive for the generation of antibody-drug conjugates (ADCs). As it is important to control the number and position of cargoes in an ADC, position-selective generation of reactive sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa2e35cdfd6f1d39c91be05daf981ef
https://pubmed.ncbi.nlm.nih.gov/34060308
https://pubmed.ncbi.nlm.nih.gov/34060308
Autor:
Marc‐André Kasper, Andreas Stengl, Philipp Ochtrop, Marcus Gerlach, Tina Stoschek, Dominik Schumacher, Jonas Helma, Martin Penkert, Eberhard Krause, Heinrich Leonhardt, Christian P. R. Hackenberger
Publikováno v:
Angewandte Chemie. 131:11757-11762
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69718f490c8eae49ec5a887833372082
https://doi.org/10.1002/ange.201904193
https://doi.org/10.1002/ange.201904193
Autor:
Marcus, Gerlach, Tina, Stoschek, Heinrich, Leonhardt, Christian P R, Hackenberger, Dominik, Schumacher, Jonas, Helma
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2012
Tubulin tyrosine ligase (TTL) catalyzes the addition of tyrosine derivatives to the C-terminal carboxylic acid of proteins. The enzyme binds to a 14-amino acid recognition sequence, termed Tub-tag, and allows for the introduction of tyrosine derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d08a3c128cfaafe81e50edd99b4988f3
https://pubmed.ncbi.nlm.nih.gov/31161516
https://pubmed.ncbi.nlm.nih.gov/31161516
Autor:
Eberhard Krause, Marcus Gerlach, Tina Stoschek, Philipp Ochtrop, Dominik Schumacher, Marc-André Kasper, Heinrich Leonhardt, Jonas Helma, Martin Penkert, Andreas Stengl, Christian P. R. Hackenberger
Publikováno v:
Angewandte Chemie (International Ed. in English)
Requirements for novel bioconjugation reactions for the synthesis of antibody–drug conjugates (ADCs) are exceptionally high, since conjugation selectivity as well as the stability and hydrophobicity of linkers and payloads drastically influence the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db4443e37f9facac987ab2e42d7f7fa
https://pubmed.ncbi.nlm.nih.gov/31250955
https://pubmed.ncbi.nlm.nih.gov/31250955
Autor:
Marc-André Kasper, Christian P. R. Hackenberger, Marcus Gerlach, Jonas Helma, Heinrich Leonhardt, Dominik Schumacher, Andreas Stengl
Publikováno v:
Organicbiomolecular chemistry. 17(20)
We introduce a chemoenzymatic strategy for straightforward in vitro generation of C-terminally linked fusion proteins. Tubulin tyrosine ligase is used for the incorporation of complementary click chemistry handles facilitating subsequent formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58834df6c041fd03d0754af0f8c50335
https://pubmed.ncbi.nlm.nih.gov/30932115
https://pubmed.ncbi.nlm.nih.gov/30932115
Autor:
Marcus Gerlach, Dominik Schumacher, Heinrich Leonhardt, Tina Stoschek, Jonas Helma, Christian P. R. Hackenberger
Publikováno v:
Methods in Molecular Biology ISBN: 9781493995455
Tubulin tyrosine ligase (TTL) catalyzes the addition of tyrosine derivatives to the C-terminal carboxylic acid of proteins. The enzyme binds to a 14-amino acid recognition sequence, termed Tub-tag, and allows for the introduction of tyrosine derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d187ec04e6d544ea0df4f6f878f21748
https://doi.org/10.1007/978-1-4939-9546-2_17
https://doi.org/10.1007/978-1-4939-9546-2_17
