Výsledky vyhledávání - "Marcus G. Davey"

Akademický článek

Chronic hypoxemia induces mitochondrial respiratory complex gene expression in the fetal sheep brainCentral MessagePerspective

Autor: James K. Moon, MD, Kendall M. Lawrence, MD, Mallory L. Hunt, MD, MBE, Marcus G. Davey, PhD, Alan W. Flake, MD, Daniel J. Licht, MD, Jonathan M. Chen, MD, Todd J. Kilbaugh, MD, J. William Gaynor, MD, Daniel P. Beiting, PhD

Publikováno v: JTCVS Open, Vol 10, Iss , Pp 342-349 (2022)

Objective: The molecular pathways underlying hypoxemia-induced alterations in neurodevelopment of infants with congenital heart disease have not been delineated. We used transcriptome analysis to investigate differential gene expression induced by hy

Externí odkaz: https://doaj.org/article/b4695444847e46a0ad8e73509db2acf1

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Akademický článek

Contrast‐enhanced ultrasound imaging can be used to evaluate fetal cerebral perfusion: potential implications for fetal surgery

Autor: Kendall M. Lawrence, Barbara E. Coons, Anush Sridharan, Avery C. Rossidis, Marcus G. Davey, Alan W. Flake, Ryne A. Didier

Publikováno v: Translational Medicine Communications, Vol 6, Iss 1, Pp 1-8 (2021)

Abstract Background Fetal surgery is increasingly performed to correct congenital defects. Currently, fetal brain perfusion cannot be assessed intra-operatively. The purpose of this study was to determine if contrast-enhanced ultrasound (CEUS) could

Externí odkaz: https://doaj.org/article/9b92be659303483c8e5c4899654d2a52

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Akademický článek

An extra-uterine system to physiologically support the extreme premature lamb

Autor: Emily A. Partridge, Marcus G. Davey, Matthew A. Hornick, Patrick E. McGovern, Ali Y. Mejaddam, Jesse D. Vrecenak, Carmen Mesas-Burgos, Aliza Olive, Robert C. Caskey, Theodore R. Weiland, Jiancheng Han, Alexander J. Schupper, James T. Connelly, Kevin C. Dysart, Jack Rychik, Holly L. Hedrick, William H. Peranteau, Alan W. Flake

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)

The ability to support the development of a premature fetus in the form of an extracorporeal system has had limited success. Here, the authors show that an extra-uterine device that mimics the intra-uterine environment can provide physiologic support

Externí odkaz: https://doaj.org/article/45db932763ce4371b11c234c5b821457

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Injury and a program of fetal wound healing in the fetal and neonatal extrahepatic bile duct

IntroductionBiliary atresia (BA) is an obstructive cholangiopathy that initially affects the extrahepatic bile ducts (EHBDs) of neonates. The etiology is uncertain, but evidence points to a prenatal cause; however, the response of the fetal EHBD to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::272df5e6ba1a178955de99f3f74a99e8
https://doi.org/10.1101/2022.12.15.520656

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Akademický článek

Induction of Immune Tolerance to Foreign Protein via Adeno-Associated Viral Vector Gene Transfer in Mid-Gestation Fetal Sheep.

Autor: Marcus G Davey, John S Riley, Abigail Andrews, Alec Tyminski, Maria Limberis, Jennifer E Pogoriler, Emily Partridge, Aliza Olive, Holly L Hedrick, Alan W Flake, William H Peranteau

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0171132 (2017)

A major limitation to adeno-associated virus (AAV) gene therapy is the generation of host immune responses to viral vector antigens and the transgene product. The ability to induce immune tolerance to foreign protein has the potential to overcome thi

Externí odkaz: https://doaj.org/article/7d8d3bc09de7417bac527a2a41c0696c

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Contrast‐enhanced ultrasound imaging can be used to evaluate fetal cerebral perfusion: potential implications for fetal surgery

Autor: Alan W. Flake, Anush Sridharan, Marcus G. Davey, Avery C. Rossidis, Barbara E. Coons, Ryne A. Didier, Kendall M. Lawrence

Publikováno v: Translational Medicine Communications, Vol 6, Iss 1, Pp 1-8 (2021)

Background Fetal surgery is increasingly performed to correct congenital defects. Currently, fetal brain perfusion cannot be assessed intra-operatively. The purpose of this study was to determine if contrast-enhanced ultrasound (CEUS) could be used t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857453892f9232e7afbcdf0ea3de7313
https://doaj.org/article/9b92be659303483c8e5c4899654d2a52

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Contrast‐Enhanced Brain Ultrasound Perfusion Metrics in the EXTra ‐Uterine Environment for Neonatal Development ( EXTEND ): Correlation With Hemodynamic Parameters

Autor: Kendall M. Lawrence, Ryne A. Didier, Anush Sridharan, Marcus G. Davey, Alan W. Flake, Barbara E. Coons

Publikováno v: Journal of Ultrasound in Medicine. 40:2571-2579

Objectives Contrast-enhanced ultrasound (CEUS) can provide quantitative perfusion metrics and may be useful to detect cerebral pathology in neonates and premature infants, particularly in extrauterine environments. The effect of hemodynamics on cereb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e25fa4075dcd21a93c918b5f922b3ef
https://doi.org/10.1002/jum.15642

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Artificial placenta and womb technology: Past, current, and future challenges towards clinical translation

Autor: Alan W. Flake, Felix De Bie, Abby C. Larson, Marcus G. Davey, Jan Deprest

Publikováno v: Prenatal Diagnosis. 41:145-158

Extreme prematurity remains a major cause of neonatal mortality and severe long-term morbidity. Current neonatal care is associated with significant morbidity due to iatrogenic injury and developmental immaturity of extreme premature infants. A more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c850859e06002bef0901fe4b8bbce28d
https://doi.org/10.1002/pd.5821

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