Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Marcus Fechheimer"'
Autor:
Yun Dong, Sonbol Shahid-Salles, Dan Sherling, Nathan Fechheimer, Nathan Iyer, Lance Wells, Marcus Fechheimer, Ruth Furukawa
Publikováno v:
Biology Open, Vol 5, Iss 6, Pp 807-818 (2016)
Hirano bodies are eosinophilic, actin-rich inclusions found in autopsied brains in numerous neurodegenerative diseases. The mechanism of Hirano body formation is unknown. Mass spectrometry analysis was performed to identify proteins from partially pu
Externí odkaz:
https://doaj.org/article/882dfcef50e4489ca331378b3d1ef8d1
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44996 (2012)
The main pathological hallmarks of Alzheimer's disease are amyloid-beta plaques and neurofibrillary tangles, which are primarily composed of amyloid precursor protein (APP) and tau, respectively. These proteins and their role in the mechanism of neur
Externí odkaz:
https://doaj.org/article/10041a6dfa83495b9757551b5861f6c8
Autor:
Sonbol Shahid-Salles, Yun Dong, Marcus Fechheimer, Nathan Fechheimer, Ruth Furukawa, Dan Sherling, Nathan Iyer, Lance Wells
Publikováno v:
Biology Open
Biology Open, Vol 5, Iss 6, Pp 807-818 (2016)
Biology Open, Vol 5, Iss 6, Pp 807-818 (2016)
Hirano bodies are eosinophilic, actin-rich inclusions found in autopsied brains in numerous neurodegenerative diseases. The mechanism of Hirano body formation is unknown. Mass spectrometry analysis was performed to identify proteins from partially pu
Publikováno v:
Eukaryotic Cell. 13:625-634
Hirano bodies are paracrystalline F-actin-rich structures associated with diverse conditions, including neurodegeneration and aging. Generation of model Hirano bodies using altered forms of Dictyostelium 34-kDa actin-bundling protein allows studies o
Publikováno v:
CBE Life Sciences Education
Assessment of undergraduate research (UR) programs using participant surveys has produced a wealth of information about design, implementation, and perceived benefits of UR programs. However, measurement of student participation university wide, and
Autor:
Jason K. Clark, Jonathon D. Crystal, Ruth Furukawa, Marcus Fechheimer, John J. Wagner, Matthew Furgerson
Publikováno v:
Neurobiology of learning and memory. 125
Alzheimer's disease is a neurodegenerative condition believed to be initiated by production of amyloid-beta peptide, which leads to synaptic dysfunction and progressive memory loss. Using a mouse model of Alzheimer's disease (3xTg-AD), an 8-arm radia
Publikováno v:
Cell Motility and the Cytoskeleton. 62:210-231
Actin-bundling proteins organize actin filaments into densely packed bundles. In Dictyostelium discoideum two abundant proteins display calcium-regulated bundling activity, fimbrin and the 34-kDa protein (ABP34). Using a GFP fusion we observed transi
Publikováno v:
Journal of Cell Science. 115:1939-1949
We report the serendipitous development of the first cultured cell models of Hirano bodies. Myc-epitope-tagged forms of the 34 kDa actin bundling protein (amino acids 1-295) and the CT fragment (amino acids 124-295) of the 34 kDa protein that exhibit
Autor:
Parker Evans, Ruth Furukawa, William Spears, John Michael Sweetnam, Marcus Fechheimer, Matthew Furgerson, Marla Gearing
Publikováno v:
BMC Neuroscience
Background Hirano bodies are actin-rich paracrystalline inclusions found in brains of patients with Alzheimer’s disease (AD), frontotemporal dementia (FTD), and in normal aged individuals. Although studies of post-mortem brain tissue provide clues
Autor:
Marcus Fechheimer, Angelika A. Noegel, Paul R. Fisher, Francisco Rivero, G. Gerisch, Josef Prassler
Publikováno v:
Current Biology. 7:889-892
Chemotactic aggregation of starving amoebae of Dictyostelium discoideum leads to formation of a motile, multicellular organism – the slug – whose anterior tip controls its phototactic and thermotactic behaviour. To determine whether proteins that