Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Marcus D. Goncalves"'
Autor:
Emily J. Gallagher, Heather Moore, Mario E. Lacouture, Susan F. Dent, Azeez Farooki, Marcus D. Goncalves, Claudine Isaacs, Abigail Johnston, Dejan Juric, Zoe Quandt, Laura Spring, Brian Berman, Melanie Decker, Gabriel N. Hortobagyi, Benjamin H. Kaffenberger, Bernice Y. Kwong, Timothy Pluard, Ruta Rao, Lee Schwartzberg, Michael S. Broder
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Hyperglycemia and rash are expected but challenging adverse events of phosphatidylinositol-3-kinase inhibition (such as with alpelisib). Two modified Delphi panels were conducted to provide consensus recommendations for managing hyperglycemi
Externí odkaz:
https://doaj.org/article/8183fb8cce4340f9881e7c5f5b6eef4c
Autor:
Tahj A. Blow, Anirudh Murthy, Rahul Grover, Emily Schwitzer, David M. Nanus, Darragh Halpenny, Andrew J. Plodkowski, Lee W. Jones, Marcus D. Goncalves
Publikováno v:
European Urology Open Science, Vol 57, Iss , Pp 1-7 (2023)
Background: Androgen deprivation therapy (ADT) is a common treatment modality for men with prostate cancer. Increases in adipose tissue mass and decreases in skeletal muscle mass are known on-target adverse effects of standard ADT. The effects of new
Externí odkaz:
https://doaj.org/article/f9ad575386084e68a42cc7bee697328a
Autor:
Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber, Thorsten Wiederhold, Tomer M. Yaron, Emily M. Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N. Paddock, Guoan Zhang, Benjamin D. Hopkins, Owen McGuinness, Robert E. Schwartz, Baran A. Ersoy, Lewis C. Cantley, Jared L. Johnson, Marcus D. Goncalves
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113535- (2023)
Summary: The phosphoinositide 3-kinase p110α is an essential mediator of insulin signaling and glucose homeostasis. We interrogated the human serine, threonine, and tyrosine kinome to search for novel regulators of p110α and found that the Hippo ki
Externí odkaz:
https://doaj.org/article/a5e7df93b0a7464587f421f871a959bf
Autor:
Lucie Yammine, Belén Picatoste, Nazish Abdullah, Rosemary A. Leahey, Emma F. Johnson, Nicolás Gómez-Banoy, Carolina Rosselot, Jennifer Wen, Tahmina Hossain, Marcus D. Goncalves, James C. Lo, Adolfo Garcia-Ocaña, Timothy E. McGraw
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101831- (2023)
Objective: Glucose-dependent insulinotropic polypeptide (GIP) has a role in controlling postprandial metabolic tone. In humans, a GIP receptor (GIPR) variant (Q354, rs1800437) is associated with a lower body mass index (BMI) and increased risk for Ty
Externí odkaz:
https://doaj.org/article/08e30cb16fb344d1bf22ff6b6349e352
Autor:
Ezequiel Dantas, Anirudh Murthy, Tanvir Ahmed, Mujmmail Ahmed, Shakti Ramsamooj, Maurice A. Hurd, Tiffany Lam, Murtaza Malbari, Christopher Agrusa, Olivier Elemento, Chen Zhang, Darryl J. Pappin, Timothy E. McGraw, Brendon M. Stiles, Nasser K. Altorki, Marcus D. Goncalves
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Background Lung cancer remains the major cause of cancer‐related deaths worldwide. Early stages of lung cancer are characterized by long asymptomatic periods that are ineffectively identified with the current screening programs. This defic
Externí odkaz:
https://doaj.org/article/9f3f0facc0d04731a5086808193bc9a9
Autor:
Andre Lima Queiroz, Ezequiel Dantas, Shakti Ramsamooj, Anirudh Murthy, Mujmmail Ahmed, Elizabeth R. M. Zunica, Roger J. Liang, Jessica Murphy, Corey D. Holman, Curtis J. Bare, Gregory Ghahramani, Zhidan Wu, David E. Cohen, John P. Kirwan, Lewis C. Cantley, Christopher L. Axelrod, Marcus D. Goncalves
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Cancer-associated cachexia is characterized by loss of body weight, skeletal muscle and adipose tissue which relates to higher mortality in cancer patients. Here, the authors show in a lung cancer murine model that both ActRIIB signalling inhibition
Externí odkaz:
https://doaj.org/article/dc0384978f5f41459c1d29179df85639
Autor:
Dazhi Liu, Michael A. Weintraub, Christine Garcia, Marcus D. Goncalves, Ann Elizabeth Sisk, Alissa Casas, James J. Harding, Stephen Harnicar, Alexander Drilon, Komal Jhaveri, James H. Flory
Publikováno v:
Cancer Medicine, Vol 11, Iss 8, Pp 1796-1804 (2022)
Abstract Purpose The phosphoinositide 3‐kinase (PI3K)/protein kinase B (AKT) pathway controls insulin sensitivity and glucose metabolism. Hyperglycemia is one of the most common on‐target adverse effects (AEs) of PI3K/AKT inhibitors. As several P
Externí odkaz:
https://doaj.org/article/6261ca0f91da4aafad9291fcc66547c9
Autor:
Hope S. Rugo, Mario E. Lacouture, Marcus D. Goncalves, Umesh Masharani, Matti S. Aapro, Joyce A. O'Shaughnessy
Publikováno v:
Breast, Vol 61, Iss , Pp 156-167 (2022)
Purpose: The oral, α-specific phosphatidylinositol-3-kinase (PI3Kα) inhibitor alpelisib is the first PI3K inhibitor approved for the treatment of advanced breast cancer. As alpelisib is a relatively new therapeutic option, specific guidance and a m
Externí odkaz:
https://doaj.org/article/c6c4f39f76af47a99f7d292ece4d71d7
Autor:
Roger J. Liang, Samuel Taylor, Navid Nahiyaan, Junho Song, Charles J. Murphy, Ezequiel Dantas, Shuyuan Cheng, Ting-Wei Hsu, Shakti Ramsamooj, Rahul Grover, Seo-Kyoung Hwang, Bryan Ngo, Lewis C. Cantley, Kyu Y. Rhee, Marcus D. Goncalves
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-13 (2021)
Abstract Background Fructose is an abundant source of carbon and energy for cells to use for metabolism, but only certain cell types use fructose to proliferate. Tumor cells that acquire the ability to metabolize fructose have a fitness advantage ove
Externí odkaz:
https://doaj.org/article/9ff1651a39bd47cba145113c9105b107
Autor:
Rodney Sufra, Jean Lookens Pierre, Eliezer Dade, Vanessa Rouzier, Alexandra Apollon, Stephano St Preux, Fabiola Préval, Joseph Inddy, Miranda Metz, Olga Tymejczyk, Denis Nash, Rodolphe Malebranche, Marie Deschamps, Jean W. Pape, Marcus D. Goncalves, Margaret L. McNairy, Lily D. Yan
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
IntroductionDiabetes mellitus is a chronic noncommunicable disease associated with death and major disability, with increasing prevalence in low- and middle-income countries. There is limited population-based data about diabetes in Haiti. The objecti
Externí odkaz:
https://doaj.org/article/9e1f31726af74b759044017e9248717a