Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Marcus CS"'
Autor:
Armstrong, Jane F, Campo, Brice, Alexander, Stephen PH, Arendse, Lauren B, Cheng, Xiu, Davenport, Anthony P, Faccenda, Elena, Fidock, David A, Godinez-Macias, Karla P, Harding, Simon D, Kato, Nobutaka, Lee, Marcus CS, Luth, Madeline R, Mazitschek, Ralph, Mittal, Nimisha, Niles, Jacquin C, Okombo, John, Ottilie, Sabine, Pasaje, Charisse Flerida A, Probst, Alexandra S, Rawat, Mukul, Rocamora, Frances, Sakata-Kato, Tomoyo, Southan, Christopher, Spedding, Michael, Tye, Mark A, Yang, Tuo, Zhao, Na, Davies, Jamie A
Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::4d380130dac8fd2fb970369c12f8763e
https://www.repository.cam.ac.uk/handle/1810/350816
https://www.repository.cam.ac.uk/handle/1810/350816
Autor:
Armstrong, Jane, Campo, Brice, Alexander, Stephen P H, Arendse, Lauren B, Cheng, Xiu, Davenport, Anthony P, Faccenda, Elena, Fidock, David A, Godinez-Macias, Karla P, Harding, Simon D, Kato, Nobutaka, Lee, Marcus CS, Luth, Madeline R, Mazitschek, Ralph, Mittal, Nimisha, Niles, Jacquin C, Okombo, John, Ottilie, Sabine, Pasaje, Charisse Flerida A, Probst, Alexandra S, Rawat, Mikul, Rocamora, Frances, Sakata-Kato, Tomoyo, Southan, Christopher, Spedding, Michael, Tye, Mark A, Yang, Tuo, Zhao, Na, Davies, Jamie A
Publikováno v:
Armstrong, J, Campo, B, Alexander, S P H, Arendse, L B, Cheng, X, Davenport, A P, Faccenda, E, Fidock, D A, Godinez-Macias, K P, Harding, S D, Kato, N, Lee, M CS, Luth, M R, Mazitschek, R, Mittal, N, Niles, J C, Okombo, J, Ottilie, S, Pasaje, C F A, Probst, A S, Rawat, M, Rocamora, F, Sakata-Kato, T, Southan, C, Spedding, M, Tye, M A, Yang, T, Zhao, N & Davies, J A 2023, ' Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY : IUPHAR review 38 ', British Journal of Pharmacology, vol. 180, no. 15, pp. 1899-1929 . https://doi.org/10.1111/bph.16144
Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3094::c6bbe9df822ebed40bf906a8529a3082
https://www.pure.ed.ac.uk/ws/files/363876435/British_J_Pharmacology_2023_Armstrong_Advances_in_malaria_pharmacology_and_the_online_guide_to_MALARIA_PHARMACOLOGY_.pdf
https://www.pure.ed.ac.uk/ws/files/363876435/British_J_Pharmacology_2023_Armstrong_Advances_in_malaria_pharmacology_and_the_online_guide_to_MALARIA_PHARMACOLOGY_.pdf
Autor:
Armstrong, Jane F, Campo, Brice, Alexander, Stephen PH, Arendse, Lauren B, Cheng, Xiu, Davenport, Anthony P, Faccenda, Elena, Fidock, David A, Godinez-Macias, Karla P, Harding, Simon D, Kato, Nobutaka, Lee, Marcus CS, Luth, Madeline R, Mazitschek, Ralph, Mittal, Nimisha, Niles, Jacquin C, Okombo, John, Ottilie, Sabine, Pasaje, Charisse Flerida A, Probst, Alexandra S, Rawat, Mukul, Rocamora, Frances, Sakata-Kato, Tomoyo, Southan, Christopher, Spedding, Michael, Tye, Mark A, Yang, Tuo, Zhao, Na, Davies, Jamie A
Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cf51aafb72c5e96478c9c66d234134
https://www.repository.cam.ac.uk/handle/1810/350119
https://www.repository.cam.ac.uk/handle/1810/350119
Autor:
Hoshizaki, Johanna, Adjalley, Sophie H, Thathy, Vandana, Judge, Kim, Berriman, Matthew, Reid, Adam J, Lee, Marcus CS
Acknowledgements: We thank Chris Newbold for his role in supporting the generation of the short-read sequencing. We thank Emma Betteridge, Alexander Dove and Sanger Scientific Operations for their assistance in generating the long-read RNA sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82614352692bf5221b547bc9d51ae279
Autor:
Krittikorn Kümpornsin, Theerarat Kochakarn, Tomas Yeo, Madeline R Luth, Richard D Pearson, Johanna Hoshizaki, Kyra A Schindler, Sachel Mok, Heekuk Park, Anne-Catrin Uhlemann, Sonia Moliner Cubel, Virginia Franco, Maria G Gomez-Lorenzo, Francisco Javier Gamo, Elizabeth A Winzeler, David A Fidock, Thanat Chookajorn, Marcus CS Lee
In vitro evolution of drug resistance is a powerful approach for identifying antimalarial targets, however key obstacles to eliciting resistance are the parasite inoculum size and mutation rate. Here we sought to increase parasite genetic diversity t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a527ff3bdbbad66b4465100592819b1d
https://doi.org/10.1101/2022.08.23.504974
https://doi.org/10.1101/2022.08.23.504974
Autor:
Manuela Carrasquilla, Ndey Fatou Drammeh, Mukul Rawat, Theo Sanderson, Zenon Zenonos, Julian C Rayner, Marcus CS Lee
The repeated emergence of antimalarial drug resistance inPlasmodium falciparum, including to the current frontline antimalarial artemisinin, is a perennial problem for malaria control. Nextgeneration sequencing has greatly accelerated the identificat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c5f7c498fc6c67d6b741741e1ad1875
https://doi.org/10.1101/2022.04.05.487250
https://doi.org/10.1101/2022.04.05.487250
Publikováno v:
In Structure 1999 7(7):793-802
Autor:
Baragaña, Beatriz, Hallyburton, Irene, Lee, Marcus CS, Norcross, Neil R, Grimaldi, Raffaella, Otto, Thomas D, Proto, William R, Blagborough, Andrew M, Meister, Stephan, Wirjanata, Grennady, Ruecker, Andrea, Upton, Leanna M, Abraham, Tara S, Almeida, Mariana J, Pradhan, Anupam, Porzelle, Achim, Luksch, Torsten, Martínez, María Santos, Bolscher, Judith M, Woodland, Andrew, Norval, Suzanne, Zuccotto, Fabio, Thomas, John, Simeons, Frederick, Stojanovski, Laste, Osuna-Cabello, Maria, Brock, Paddy M, Churcher, Tom S, Sala, Katarzyna A, Zakutansky, Sara E, Jiménez-Díaz, María Belén, Sanz, Laura Maria, Riley, Jennifer, Basak, Rajshekhar, Campbell, Michael, Avery, Vicky M, Sauerwein, Robert W, Dechering, Koen J, Noviyanti, Rintis, Campo, Brice, Frearson, Julie A, Angulo-Barturen, Iñigo, Ferrer-Bazaga, Santiago, Gamo, Francisco Javier, Wyatt, Paul G, Leroy, Didier, Siegl, Peter, Delves, Michael J, Kyle, Dennis E, Wittlin, Sergio, Marfurt, Jutta, Price, Ric N, Sinden, Robert E, Winzeler, Elizabeth A, Charman, Susan A, Bebrevska, Lidiya, Gray, David W, Campbell, Simon, Fairlamb, Alan H, Willis, Paul A, Rayner, Julian C, Fidock, David A, Read, Kevin D, Gilbert, Ian H
Publikováno v:
Nature, vol 522, iss 7556
There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and novel modes of action, to widen the scope of treatment and to overcome emerging drug resistance. Here we describe the discovery of DDD107498, a compound with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::9ae0e7acbcdadc88d5abe0bbdf2135ad
https://escholarship.org/uc/item/1m64023f
https://escholarship.org/uc/item/1m64023f
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