Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Marcus C S Lee"'
Autor:
Nina F Gnädig, Barbara H Stokes, Rachel L Edwards, Gavreel F Kalantarov, Kim C Heimsch, Michal Kuderjavy, Audrey Crane, Marcus C S Lee, Judith Straimer, Katja Becker, Ilya N Trakht, Audrey R Odom John, Sachel Mok, David A Fidock
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008482 (2020)
The emergence of artemisinin (ART) resistance in Plasmodium falciparum intra-erythrocytic parasites has led to increasing treatment failure rates with first-line ART-based combination therapies in Southeast Asia. Decreased parasite susceptibility is
Externí odkaz:
https://doaj.org/article/63f0cf7a413247b28ca9b575fa65febb
Autor:
Maryia Karpiyevich, Sophie Adjalley, Marco Mol, David B Ascher, Bethany Mason, Gerbrand J van der Heden van Noort, Heike Laman, Huib Ovaa, Marcus C S Lee, Katerina Artavanis-Tsakonas
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1008086 (2019)
Plasmodium parasites are the causative agents of malaria, a disease with wide public health repercussions. Increasing drug resistance and the absence of a vaccine make finding new chemotherapeutic strategies imperative. Components of the ubiquitin an
Externí odkaz:
https://doaj.org/article/1ca26c960e474f2eb5b3cb1b446748e2
Autor:
Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline R. Luth, Krittikorn Kumpornsin, Eva S. Istvan, Joon Sung Park, Kate J. Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N. Bhebhe, Dana M. Klug, Peter J. Rutledge, Luiz C. Godoy, Sumanta Dey, Mariana Laureano De Souza, Jair L. Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerry Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas Williamson, Gouranga P. Jana, Bikash C. Maity, Patrick Thomson, Thomas Foley, Derek S. Tan, Jacquin C. Niles, Byung Woo Han, Daniel E. Goldberg, Jeremy Burrows, David A. Fidock, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael D. W. Griffin, Matthew H. Todd, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a ne
Externí odkaz:
https://doaj.org/article/74ceb3d2587846d1a75544faccf7d8f1
Autor:
Eva Stadler, Mohamed Maiga, Lukas Friedrich, Vandana Thathy, Claudia Demarta-Gatsi, Antoine Dara, Fanta Sogore, Josefine Striepen, Claude Oeuvray, Abdoulaye A. Djimdé, Marcus C. S. Lee, Laurent Dembélé, David A. Fidock, David S. Khoury, Thomas Spangenberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract We report an analysis of the propensity of the antimalarial agent cabamiquine, a Plasmodium-specific eukaryotic elongation factor 2 inhibitor, to select for resistant Plasmodium falciparum parasites. Through in vitro studies of laboratory st
Externí odkaz:
https://doaj.org/article/fc7d61999951431e86b5f6942e16ac55
Autor:
Krittikorn Kümpornsin, Theerarat Kochakarn, Tomas Yeo, John Okombo, Madeline R. Luth, Johanna Hoshizaki, Mukul Rawat, Richard D. Pearson, Kyra A. Schindler, Sachel Mok, Heekuk Park, Anne-Catrin Uhlemann, Gouranga P. Jana, Bikash C. Maity, Benoît Laleu, Elodie Chenu, James Duffy, Sonia Moliner Cubel, Virginia Franco, Maria G. Gomez-Lorenzo, Francisco Javier Gamo, Elizabeth A. Winzeler, David A. Fidock, Thanat Chookajorn, Marcus C. S. Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract In vitro evolution of drug resistance is a powerful approach for identifying antimalarial targets, however, key obstacles to eliciting resistance are the parasite inoculum size and mutation rate. Here we sought to increase parasite genetic d
Externí odkaz:
https://doaj.org/article/cd0bb7acaa454eeba503bf34e9f1ecc8
Autor:
Johanna Hoshizaki, Sophie H. Adjalley, Vandana Thathy, Kim Judge, Matthew Berriman, Adam J. Reid, Marcus C. S. Lee
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-6 (2023)
Externí odkaz:
https://doaj.org/article/8c60c21f7b9446a48dac410225f0927c
Autor:
Johanna Hoshizaki, Sophie H. Adjalley, Vandana Thathy, Kim Judge, Matthew Berriman, Adam J. Reid, Marcus C. S. Lee
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Important regulation occurs at the level of transcription in Plasmodium falciparum and growing evidence suggests that these apicomplexan parasites have complex regulatory networks. Recent studies implicate long noncoding RNAs (lnc
Externí odkaz:
https://doaj.org/article/e96b697c12f34df39580518217d21807
Autor:
Deyun Qiu, Jinxin V. Pei, James E. O. Rosling, Vandana Thathy, Dongdi Li, Yi Xue, John D. Tanner, Jocelyn Sietsma Penington, Yi Tong Vincent Aw, Jessica Yi Han Aw, Guoyue Xu, Abhai K. Tripathi, Nina F. Gnadig, Tomas Yeo, Kate J. Fairhurst, Barbara H. Stokes, James M. Murithi, Krittikorn Kümpornsin, Heath Hasemer, Adelaide S. M. Dennis, Melanie C. Ridgway, Esther K. Schmitt, Judith Straimer, Anthony T. Papenfuss, Marcus C. S. Lee, Ben Corry, Photini Sinnis, David A. Fidock, Giel G. van Dooren, Kiaran Kirk, Adele M. Lehane
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
In a recent clinical trial for oral administration of cipargamin in individuals with malaria, there was an emergence of recrudescent parasites with a G358S mutation in PfATP4. In this work, the authors investigate the effect of this mutation on the f
Externí odkaz:
https://doaj.org/article/7abacde286514d8b929ffa3fbc4d3a0f
Autor:
Eva Stadler, Mohamed Maiga, Lukas Friedrich, Vandana Thathy, Claudia Demarta-Gatsi, Antoine Dara, Fanta Sogore, Josefine Striepen, Claude Oeuvray, Abdoulaye A. Djimdé, Marcus C. S. Lee, Laurent Dembélé, David A. Fidock, David S. Khoury, Thomas Spangenberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/b0c7124584a34f698dd6a12c343873cc
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
CRISPR editing has enabled the rapid creation of fluorescent Plasmodium transgenic lines, facilitating a deeper understanding of parasite biology. The impact of genetic perturbations such as gene disruption or the introduction of drug resistance alle
Externí odkaz:
https://doaj.org/article/b874966ba7fa4effaa1009cd37ee3274