The DNA damage response in advanced ovarian cancer: functional analysis combined with machine learning identifies signatures that correlate with chemotherapy sensitivity and patient outcome

Autor: Thomas D. J. Walker, Zahra F. Faraahi, Marcus J. Price, Amy Hawarden, Caitlin A. Waddell, Bryn Russell, Dominique M. Jones, Aiste McCormick, N. Gavrielides, S. Tyagi, Laura C. Woodhouse, Bethany Whalley, Connor Roberts, Emma J. Crosbie, Richard J. Edmondson

Publikováno v: Walker, T D J, Faraahi, Z F, Price, M J, Hawarden, A, Waddell, C A, Russell, B, Jones, D M, McCormick, A, Gavrielides, N, Tyagi, S, Woodhouse, L C, Whalley, B, Roberts, C, Crosbie, E J & Edmondson, R J 2023, ' The DNA damage response in advanced ovarian cancer: functional analysis combined with machine learning identifies signatures that correlate with chemotherapy sensitivity and patient outcome ', British Journal of Cancer . https://doi.org/10.1038/s41416-023-02168-3

Background Ovarian cancers are hallmarked by chromosomal instability. New therapies deliver improved patient outcomes in relevant phenotypes, however therapy resistance and poor long-term survival signal requirements for better patient preselection.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1280700fee921d034c284eae9e468e52
https://doi.org/10.1038/s41416-023-02168-3

CRISPR-dCas9 Mediated Cytosine Deaminase Base Editing in Bacillus subtilis

Autor: Yang Liu, Sili Yu, Meng Wang, Marcus A. Price, Changhao Bi, Xiaomeng Ni, Yanmei Guo, Susan J. Rosser, Yu Wang

Publikováno v: Yu, S, Price, M A, Wang, Y, Liu, Y, Guo, Y, Ni, X, Rosser, S J, Bi, C & Wang, M 2020, ' CRISPR-dCas9 mediated cytosine deaminase base editing in bacillus subtilis ', ACS Synthetic Biology, vol. 9, no. 7, pp. 1781-1789 . https://doi.org/10.1021/acssynbio.0c00151

Base editing technology based on clustered regularly interspaced short palindromic repeats/associated protein 9 (CRISPR/Cas9) is a recent addition to the family of CRISPR technologies. Compared with the traditional CRISPR/Cas9 technology, it does not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafe97e2a444736b5680a36b5719dfb2
https://doi.org/10.1021/acssynbio.0c00151

Short term inhibition of immune checkpoint proteins increases ex vivo expansion of tumour infiltrating lymphocytes in high grade serous ovarian cancer

Autor: Caitlin A Waddell, Marcus J. Price, Eleanor J. Cheadle, Gemma L. Owens, Richard J. Edmondson

Background: Ovarian cancer remains the most lethal gynaecological malignancy and there is an urgent need for the development of further therapies to improve patient survival. Tumour infiltrating lymphocyte (TIL) therapy has shown clear efficacy in im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93f698d4572ec5ef8311566ed429c3b7
https://doi.org/10.21203/rs.3.rs-1477937/v1

Glycosylase base editors enable C-to-A and C-to-G base changes

Autor: Marcus A. Price, Ju Li, Susan J. Rosser, Muzi Hu, Siwei Li, Changhao Bi, Dongdong Zhao, Xiuqing Xin, Xueli Zhang

Publikováno v: Zhao, D, Li, J, Li, S, Xin, X, Hu, M, Price, M A, Rosser, S J, Bi, C & Zhang, X 2020, ' Glycosylase base editors enable C-to-A and C-to-G base changes ', Nature Biotechnology, vol. 39, pp. 35-40 . https://doi.org/10.1038/s41587-020-0592-2

Current base editors (BEs) catalyze only base transitions (C to T and A to G) and cannot produce base transversions. Here we present BEs that cause C-to-A transversions in Escherichia coli and C-to-G transversions in mammalian cells. These glycosylas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a85ef8966a5ef9ed337eba981a07db
https://www.pure.ed.ac.uk/ws/files/192864573/GlycosylaseBaseEditors.pdf

Glycosylase base editors enable C-to-A and C-to-G base changes

Autor: Dongdong, Zhao, Ju, Li, Siwei, Li, Xiuqing, Xin, Muzi, Hu, Marcus A, Price, Susan J, Rosser, Changhao, Bi, Xueli, Zhang

Publikováno v: Nature biotechnology. 39(1)

Current base editors (BEs) catalyze only base transitions (C to T and A to G) and cannot produce base transversions. Here we present BEs that cause C-to-A transversions in Escherichia coli and C-to-G transversions in mammalian cells. These glycosylas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68c3212d94a5fa44a8c5c826eb3acbf3
https://pubmed.ncbi.nlm.nih.gov/32951947