Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Marcus A Lawson"'
Autor:
Alexandra K Brooks, Marcus A Lawson, Jennifer L Rytych, Kevin C Yu, Tiffany M Janda, Andrew J Steelman, Robert H McCusker
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Elevated levels of circulating pro-inflammatory cytokines are associated with symptomology of several psychiatric disorders, notably major depressive disorder. Symptomology has been linked to inflammation/cytokine-dependent induction of the Kynurenin
Externí odkaz:
https://doaj.org/article/e620107f2afb4c94a02034380d2bcf0f
Autor:
Dianelys Gonzalez-Pena, Scott E Nixon, Bruce R Southey, Marcus A Lawson, Robert H McCusker, Alvaro G Hernandez, Robert Dantzer, Keith W Kelley, Sandra L Rodriguez-Zas
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157727 (2016)
Microglia in the brain and macrophages in peripheral organs are cell types responsible for immune response to challenges. Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunomodulatory enzyme of the tryptophan pathway that is expressed in the brain. The
Externí odkaz:
https://doaj.org/article/5e4001792cca421d94510a0c40f93381
Autor:
Dianelys Gonzalez-Pena, Scott E Nixon, Jason C O'Connor, Bruce R Southey, Marcus A Lawson, Robert H McCusker, Tania Borras, Debbie Machuca, Alvaro G Hernandez, Robert Dantzer, Keith W Kelley, Sandra L Rodriguez-Zas
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150858 (2016)
Depression symptoms following immune response to a challenge have been reported after the recovery from sickness. A RNA-Seq study of the dysregulation of the microglia transcriptome in a model of inflammation-associated depressive behavior was undert
Externí odkaz:
https://doaj.org/article/5181b5e3b1f74903ad63b2e1dcade39d
Autor:
Stephanie M. Matt, Aditi Das, Adrienne M. Antonson, Megan P. Caputo, Rodney W. Johnson, Josephine E. Watson, Marcus A. Lawson, Brian J. Leyshon, Emily C. Radlowski
Publikováno v:
Brain Behav Immun
Neonatal brain development can be disrupted by infection that results in microglial cell activation and neuroinflammation. Studies indicate that polyunsaturated fatty acids (PUFAs) and their metabolites can resolve inflammation. It is not known if di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1adf1c23db98cbeb5e875849975ca9
https://doi.org/10.1016/j.bbi.2019.06.046
https://doi.org/10.1016/j.bbi.2019.06.046
Autor:
Marcus A. Lawson, Adrienne M. Antonson, Megan P. Caputo, Stephanie M. Matt, Brian J. Leyshon, Rodney W. Johnson
Publikováno v:
Proceedings of the National Academy of Sciences. 116:20190-20200
Maternal infections during pregnancy are associated with increased risk of neurodevelopmental disorders, although the precise mechanisms remain to be elucidated. Previously, we established a maternal immune activation (MIA) model using swine, which r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd704b87aa690e1d4394c788d800634
https://doi.org/10.1073/pnas.1817014116
https://doi.org/10.1073/pnas.1817014116
Autor:
Keith W. Kelley, Cong Wu, Sandra L. Rodriguez-Zas, Scott E. Nixon, Elena V. Romanova, Jason C. O'Connor, Bruce R. Southey, Marcus A. Lawson, Cynthia Zavala, Robert Dantzer, Jonathan V. Sweedler, Robert H. McCusker, Robmay Garcia
Publikováno v:
Psychoneuroendocrinology. 97:47-58
Background Peripheral immune challenge can elicit microglia activation and depression-related symptoms. The balance of inflammatory signals in the tryptophan pathway can skew the activity of indoleamine-pyrrole 2,3 dioxygenase (IDO1) towards the meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3f919f2a356460b237a28869d27252
https://doi.org/10.1016/j.psyneuen.2018.06.024
https://doi.org/10.1016/j.psyneuen.2018.06.024
Publikováno v:
Brain, Behavior, and Immunity. 69:321-335
Behavioral symptoms associated with mood disorders have been intimately linked with immunological and psychological stress. Induction of immune and stress pathways is accompanied by increased tryptophan entry into the Kynurenine (Kyn) Pathway as gove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbba97027614ad980fbefba47c74f8b
https://doi.org/10.1016/j.bbi.2017.12.006
https://doi.org/10.1016/j.bbi.2017.12.006
Autor:
Jennifer L. Rytych, Adrienne M. Antonson, Marcus A. Lawson, Emily C. Radlowski, Rodney W. Johnson
Publikováno v:
Brain, Behavior, and Immunity. 59:300-312
Maternal infection during pregnancy increases risk for neurodevelopmental disorders and reduced stress resilience in offspring, but the mechanisms are not fully understood. We hypothesized that piglets born from gilts infected with a respiratory viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36163e933ceb5f3c0013efb1c3df9f7
https://doi.org/10.1016/j.bbi.2016.09.019
https://doi.org/10.1016/j.bbi.2016.09.019
Autor:
Stephanie M. Matt, Jalisa D. Zimmerman, Marcus A. Lawson, Angela C. Bustamante, Monica Uddin, Rodney W. Johnson
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Frontiers in Neuroscience
Frontiers in Neuroscience
Activity of DNA methyltransferases (DNMTs), the enzymes that catalyze DNA methylation, is dynamically regulated in the brain. DNMT inhibitors alter DNA methylation globally in the brain and at individual neural plasticity-associated genes, but how DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a5e532c49bdd3a5b42c4a016aaddb9
https://www.frontiersin.org/article/10.3389/fnins.2018.00636/full
https://www.frontiersin.org/article/10.3389/fnins.2018.00636/full
Autor:
Stephanie M. Matt, Jacob M. Allen, Marcus A. Lawson, Lucy J. Mailing, Jeffrey A. Woods, Rodney W. Johnson
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, Vol 9 (2018)
Aging results in chronic systemic inflammation that can alter neuroinflammation of the brain. Specifically, microglia shift to a pro-inflammatory phenotype predisposing them to hyper-activation upon stimulation by peripheral immune signals. It is pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fac92ef45025324833d25678b069d0