Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Marcus Ewing"'
Autor:
Jade D. Nelson, Handfield Robert Eugene, Nathan D. Ide, Hahdi H. Perfect, Esmort Chisowa, Mark P. Delude, Marcus Ewing, Durgesh V. Nadkarni, R. Matt Weekly, Mark Olivier, John J. Teixeira, Steven J. Brenek, John P. Zelina, James E. Phillips, Michele T. Drexler, Stephane Caron
Publikováno v:
Organic Process Research & Development. 16:1348-1359
Previous synthetic processes for the preparation of sulopenem involved multistep linear sequences in which the chiral sulfoxide side chain was introduced early in the process. This contribution summarizes the development of a practical and convergent
Autor:
Marcus Ewing, Stephen E. Hubbs, John VanAlsten, Timothy Norris, Grace O. Jensen, Matthew L. Jorgensen, Weiling Cai, Jon Bordner
Publikováno v:
Organic Process Research & Development. 12:447-455
Many years ago anidulafungin 1 was identified as a potentially useful medicine for the treatment of fungal infections. Its chemical and physical properties as a relatively high molecular weight semisynthetic derived from echinocandin B proved to be a
Autor:
Enrique Vazquez, Susan Deborah Lagreca, Mark Guinn, Michel Couturier, Marcus Ewing, Karl Ng, A. Morgan Stewart, Lulin Wei, Raggon Jeffrey W, Brian M. Andresen, John L. Tucker, V. John Jasys, Frank J. Urban, Garrett Moraski, Derek L. Tickner, Joel M. Hawkins, B. J. Cronin, Joseph Peter Lyssikatos, Michael D'occhio
Publikováno v:
Organic Process Research & Development. 8:643-650
As part of a fast-paced oncology program, quinolinone 1 was discovered and developed as a potent inhibitor of farnesyl transferase for the treatment of cancer. The initial synthesis, which suffered from a lengthy linear sequence and a late-stage chro
Publikováno v:
Tetrahedron Letters. 45:905-906
Treatment of a primary t-butyl carbamate (Boc) group with excess sodium t-butoxide in slightly wet tetrahydrofuran or 2-methyltetrahydrofuran provides the corresponding primary amine in excellent yield. We believe the reaction proceeds through an iso
Autor:
Timothy Norris, John VanAlsten, Stephen Hubbs, Marcus Ewing, Weiling Cai, Matthew L. Jorgensen, Jon Bordner, Grace O. Jensen
Publikováno v:
Organic Process Research & Development; Apr2008, Vol. 12 Issue 3, p447-455, 9p