Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Marcus, Soto"'
Autor:
Siva Charan Devanaboyina, Peng Li, Edward L. LaGory, Carrie Poon-Andersen, Kevin D. Cook, Marcus Soto, Zhe Wang, Khue Dang, Craig Uyeda, Ryan B. Case, Veena A. Thomas, Ronya Primack, Manuel Ponce, Mei Di, Brian Ouyang, Joelle Kaner, Sheung Kwan Lam, Mina Mostafavi
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Targeting antigens with antibodies exhibiting pH/Ca2+-dependent binding against an antigen is an attractive strategy to mitigate target-mediated disposition and antigen buffering. Studies have reported improved serum exposure of antibodies exhibiting
Externí odkaz:
https://doaj.org/article/e01cdf9351b64b009ab7296a2022f247
Autor:
Shufang Liu, Sara C. Humphreys, Kevin D. Cook, Kip P. Conner, Ana R. Correia, Alex W. Jacobitz, Melissa Yang, Ronya Primack, Marcus Soto, Rupa Padaki, Mariusz Lubomirski, Richard Smith, Marissa Mock, Veena A. Thomas
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTIn this investigation, we tested the hypothesis that a physiologically based pharmacokinetic (PBPK) model incorporating measured in vitro metrics of off-target binding can largely explain the inter-antibody variability in monoclonal antibody
Externí odkaz:
https://doaj.org/article/ba5447ad553b4a998a1ea0915308c3b4
Autor:
Shining Ma, Michelle So, Aazam Ghelani, Rohith Srivas, Anupama Sahoo, Robyn Hall, Wenjun Liu, Hao Wu, Sherman Yu, Shiping Lu, Elly Song, Taryn Cariaga, Marcus Soto, Hong Zhou, Chi-Ming Li, Ashutosh Chaudhry, Xin Luo, Sue J. Sohn
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interleukin-2 (IL-2), along with T-cell receptor (TCR) signaling, are required to control regulatory T cell (Treg) homeostasis and function in vivo. Due to the heightened sensitivity to IL-2, Tregs retain the ability to respond to low-dose or attenua
Externí odkaz:
https://doaj.org/article/4b2f7fa5bd9b408db48f01f99aa68ebe
Autor:
Kip P. Conner, Cinthia V. Pastuskovas, Marcus Soto, Veena A. Thomas, Mylo Wagner, Dan A. Rock
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The decision to pursue a monoclonal antibody (mAb) as a therapeutic for disease intervention requires the assessment of many factors, such as target-biology, including the total target burden and its accessibility at the intended site of action, as w
Externí odkaz:
https://doaj.org/article/243a6b7f7dbe4e909e8a123c532462bf
Autor:
Kenneth W Walker, Hossein Salimi-Moosavi, Gregory E Arnold, Qing Chen, Marcus Soto, Frederick W Jacobsen, John Hui
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217061 (2019)
In this study we compared the pharmacokinetic profile of four unrelated antibodies, which do not bind to mammalian antigens, in IgG1 and IgG2 frameworks in both rats and non-human primates (NHP). This allowed for extensive cross comparison of the imp
Externí odkaz:
https://doaj.org/article/14136c151f2d4a898ef46dc3efe9bd87
Autor:
Carrie Poon-Andersen, Hamsini Dhoolypala, Diana Wong, Marcus Soto, Hossein Salimi-Moosavi, Brian Chan, Agnieszka Kielczewska, Kevin D Cook
Publikováno v:
Bioanalysis. 14:581-588
Aim: To develop a method for the quantitation of effector functionless mouse surrogate IgG1 drug molecules in mouse matrices. Materials & methods: A panel of antibodies that bound specifically to N297G mutation-containing mouse IgG molecules was gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbfa912a44a756c1e5fac2594c6471b
https://doi.org/10.4155/bio-2022-0037
https://doi.org/10.4155/bio-2022-0037
Autor:
Hossein Salimi-Moosavi, Marcus Soto
Publikováno v:
The AAPS journal. 24(6)
The aim of this research was to develop a reliable non-radiometric method to measure the residual blood in tissue without the need for perfusion or radiometric measurements in biodistribution studies. It was found that the perfusion method not only w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b445e457b6793bb8e76b0b2537f9950b
https://pubmed.ncbi.nlm.nih.gov/36376552
https://pubmed.ncbi.nlm.nih.gov/36376552
Autor:
Brad Herberich, Thomas Nixey, Lin Yin, Tayo Ikotun, Kelvin K. C. Sham, Jason Long, Hongyan Li, Charles Glaus, Xuhai Be, Les P. Miranda, Yuan Cheng, Marcus Soto, James R. Falsey, Bryan D. Moyer, Robert S. Foti, Christopher M. Tegley, Chawita Netirojjanakul, Linh Tran, Kip P. Conner, Jennifer Aral, Liyue Huang, Kaustav Biswas, Justin K. Murray, Bin Wu, Loren Berry, Dean Hickman, Dan A. Rock
Publikováno v:
Drug Metabolism and Disposition. 47:1111-1121
The identification of nonopioid alternatives to treat chronic pain has received a great deal of interest in recent years. Recently, the engineering of a series of Nav1.7 inhibitory peptide-antibody conjugates has been reported, and herein, the precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aafa704103c2cd45fe6f198cffc5d5f
https://doi.org/10.1124/dmd.119.087742
https://doi.org/10.1124/dmd.119.087742
Autor:
William J. McCarty, Thomas Kornecook, Jonathan Roberts, Marcus Soto, Helming Tan, Brian A. Sparling, Paul S. Andrews, Hao Chen, Charles G. Knutson, James Meyer, Stephen Schneider, Maosheng Zhang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 371:476-486
There is an unmet medical need for nonopioid pain therapies in human populations; several pathways are under investigation for possible therapeutic intervention. Tetrahydrobiopterin (BH4) has received attention recently as a mediator of neuropathic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f03bcc2f453f7445d6302628cb7d0fe
https://doi.org/10.1124/jpet.119.257105
https://doi.org/10.1124/jpet.119.257105
Autor:
Bryan D. Moyer, Brad Herberich, Kaustav Biswas, Kenneth W. Walker, Beth D. Youngblood, Jennifer Aral, Tayo Ikotun, Min-Hwa Jasmine Lin, Linh Tran, Thomas Kornecook, Hongyan Li, Thomas Nixey, Joseph Ligutti, Shanti Amagasu, Li Yin, Xuhai Be, Kristin L. Andrews, Christopher M. Tegley, Charles Glaus, Marcus Soto, Les P. Miranda, James R. Falsey, Jason Long, Yuan Cheng, Robert S. Foti, Hossein Salimi-Moosavi, Kelvin Sham, Christopher P Ilch, Bin Wu, Justin K. Murray, Margaret Karow, Chawita Netirojjanakul, Liz Doherty
Publikováno v:
ACS Chemical Biology. 14:806-818
Drug discovery research on new pain targets with human genetic validation, including the voltage-gated sodium channel NaV1.7, is being pursued to address the unmet medical need with respect to chronic pain and the rising opioid epidemic. As part of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68d1aa4016111a37796e962e98dcd944
https://doi.org/10.1021/acschembio.9b00183
https://doi.org/10.1021/acschembio.9b00183