Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Marcus, Henze"'
Autor:
Marcus Henze, Weikang Ma, Robert L. Anderson, Thomas C. Irving, Henry M Gong, Carlos del Rio, Fiona L. Wong
Publikováno v:
Circ Res
Rationale: Myofilament length-dependent activation (LDA) is the key underlying mechanism of cardiac heterometric autoregulation, commonly referred as the Frank-Starling Law of the heart. Although alterations in LDA are common in cardiomyopathic state
Autor:
Cynthia Kelly, Robert E. Anderson, Pierpaolo Pellicori, Jean François Tamby, Scott D. Solomon, Chun Yang, Frank Wagner, Albert Camacho, Michael J. Koren, Gregory Kurio, Henk P. Swart, Narayana Prasad, Carlos L. del Rio, Wanying Li, Kate Wells, Leslie B. Forgosh, Dinesh Gupta, Ray E. Hershberger, Marcus Henze, Lars H. Lund, Anu R. Anto, Fang Liang, Kaylyn M Bell, Sam L. Teichman, Ravi Karra, Adriaan A. Voors, John G.F. Cleland, Jay M. Edelberg
Publikováno v:
European Journal of Heart Failure, 22(9), 1649-1658. Wiley
Aims: Both left ventricular (LV) and left atrial (LA) dysfunction and remodelling contribute to adverse outcomes in heart failure with reduced ejection fraction (HFrEF). Danicamtiv is a novel, cardiac myosin activator that enhances cardiomyocyte cont
Autor:
Marcus Henze, Sheerin Luis Shahidi-Latham, Emily Hollenbeck, Trisha Smit, Daniel Chin, Carlos del Rio, Frank Rohret, Kaylyn M Bell, David M. Ryba
Publikováno v:
Circulation. 142
Introduction: Hypertrophic cardiomyopathy (HCM) is a progressive disease characterized by cardiac remodeling, impaired relaxation, left-atrial enlargement, and exertional intolerance. Direct myosin-inhibition with mavacamten can normalize contractili
Publikováno v:
European Heart Journal. 41
B: Alterations in the length dependent activation (LDA) of left ventricular (LV) muscle fibres, the mechanistic driver of the Frank-Starling Law of the heart, are thought to mediate impaired LV function in heart failure (HF). However, little is known
Autor:
Chehade N. Karam, E. Douglas Lewandowski, R. John Solaro, Marcus Henze, Natasha H. Banke, Chad M. Warren
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 312:H681-H690
Although alterations in fatty acid (FA) metabolism have been shown to have a negative impact on contractility of the hypertrophied heart, the targets of action remain elusive. In this study we compared the function of skinned fiber bundles from trans
Abstract 905: Length Dependent Activation in Porcine Cardiac Myofilaments is Modulated by Mavacamten
Autor:
Thomas C. Irving, Marcus Henze, Robert E. Anderson, Weikang Ma, Carlos del Rio, Henry Gong, Fiona K. Wong
Publikováno v:
Circulation Research. 125
Length dependent activation (LDA) is a property of muscle where increased sarcomere length (SL) leads to increased force of contraction. Despite its key role in both normal and pathological states, the molecular mechanisms underlying LDA are not unde
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Autor:
Joshua M. Gorham, Yonghong Song, Johan D. Oslob, Christine E. Seidman, Brooke C. Harrison, Jonathan G. Seidman, Marc J. Evanchik, Robert S. McDowell, Robert L. Anderson, Leslie A. Leinwand, James A. Spudich, Hiroko Wakimoto, William Wan, Hector M. Rodriguez, Eric M. Green, Marcus Henze, Raja Kawas
Publikováno v:
Science. 351:617-621
Powering down yields a healthier heart In hypertrophic cardiomyopathy (HCM), the heart muscle enlarges and becomes progressively less efficient at pumping blood. HCM can be caused by mutations in components of the sarcomere (the heart's contractile u
Autor:
Brian S. Ferguson, Steven Tobia, Carlos del Rio, Marcus Henze, Christopher Zambataro, Rafael Shimkunas
Publikováno v:
Journal of Molecular and Cellular Cardiology. 140:44
Autor:
Thomas C. Irving, Makenna M. Morck, Fiona L. Wong, Joshua M. Gorham, Henry Gong, Robert L. Anderson, Darshan V. Trivedi, Roger Cooke, Kathleen M. Ruppel, Christopher S. Rogers, Jonathan G. Seidman, Marcus Henze, James A. Spudich, Weikang Ma, Eric M. Green, Saswata S. Sarkar
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However, measurements of the intrinsic force, velocity, and ATPase activity of myosin have not provided a cons
Autor:
Heather Bogie, Marcus Henze, John Yucel, Sarah Fernandes, Brain Ferguson, Marc J. Evanchik, Carlos L Rio, Christopher Zambataro
Publikováno v:
The FASEB Journal. 32