The transcription regulator ATF4 is a mediator of skeletal muscle aging.

Autor: Miller MJ; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Departments of Medicine and Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; University of Iowa, Iowa City, IA, USA., Marcotte GR; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Departments of Medicine and Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; University of Iowa, Iowa City, IA, USA., Basisty N; Buck Institute for Research on Aging, Novato, CA, USA.; National Institute on Aging, NIH, Baltimore, MD, USA., Wehrfritz C; Buck Institute for Research on Aging, Novato, CA, USA., Ryan ZC; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Departments of Medicine and Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Strub MD; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Departments of Medicine and Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., McKeen AT; University of Iowa, Iowa City, IA, USA., Stern JI; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Departments of Medicine and Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Nath KA; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Departments of Medicine and Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Rasmussen BB; University of Texas Medical Branch, Galveston, TX, USA.; Emmyon, Inc., Rochester, MN, USA., Judge AR; University of Florida, Gainesville, FL, USA.; Emmyon, Inc., Rochester, MN, USA., Schilling B; Buck Institute for Research on Aging, Novato, CA, USA., Ebert SM; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Departments of Medicine and Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. ebert.scott@mayo.edu.; Emmyon, Inc., Rochester, MN, USA. ebert.scott@mayo.edu., Adams CM; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Departments of Medicine and Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. adams.christopher2@mayo.edu.; Emmyon, Inc., Rochester, MN, USA. adams.christopher2@mayo.edu.; Iowa City Veterans Affairs Medical Center, Iowa City, IA, USA. adams.christopher2@mayo.edu.

Publikováno v: GeroScience [Geroscience] 2023 Aug; Vol. 45 (4), pp. 2525-2543. Date of Electronic Publication: 2023 Apr 04.

GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle.

Autor: Marcotte GR; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.; University of Iowa, Iowa City, Iowa, USA., Miller MJ; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.; University of Iowa, Iowa City, Iowa, USA., Kunz HE; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Ryan ZC; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Strub MD; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Vanderboom PM; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Heppelmann CJ; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Chau S; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Von Ruff ZD; University of Texas Medical Branch, Galveston, Texas, USA., Kilroe SP; University of Texas Medical Branch, Galveston, Texas, USA., McKeen AT; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.; University of Iowa, Iowa City, Iowa, USA., Dierdorff JM; University of Iowa, Iowa City, Iowa, USA., Stern JI; Department of Neurology and., Nath KA; Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Grueter CE; University of Iowa, Iowa City, Iowa, USA., Lira VA; University of Iowa, Iowa City, Iowa, USA., Judge AR; University of Florida, Gainesville, Florida, USA.; Emmyon, Inc., Rochester, Minnesota, USA., Rasmussen BB; University of Texas Medical Branch, Galveston, Texas, USA.; Emmyon, Inc., Rochester, Minnesota, USA.; University of Texas Health Science Center, San Antonio, Texas, USA., Nair KS; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Lanza IR; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Ebert SM; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Emmyon, Inc., Rochester, Minnesota, USA., Adams CM; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Emmyon, Inc., Rochester, Minnesota, USA.

Publikováno v: JCI insight [JCI Insight] 2023 Nov 22; Vol. 8 (22). Date of Electronic Publication: 2023 Nov 22.

Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle

Autor: West, DWD, Baehr, LM, Marcotte, GR, Chason, CM, Tolento, L, Gomes, AV, Bodine, SC, Baar, K

Publikováno v: The Journal of physiology, vol 594, iss 2
West, DWD; Baehr, LM; Marcotte, GR; Chason, CM; Tolento, L; Gomes, AV; et al.(2016). Acute resistance exercise activates rapamycin-sensitive and-insensitive mechanisms that control translational activity and capacity in skeletal muscle. Journal of Physiology, 594(2), 453-468. doi: 10.1113/JP271365. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/1nn2q669

© 2016 The Physiological Society. Key points: Ribosome biogenesis is the primary determinant of translational capacity, but its regulation in skeletal muscle following acute resistance exercise is poorly understood. Resistance exercise increases mus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6cdf4dc19de41269b77d91c48a6c6189
https://escholarship.org/uc/item/1nn2q669

Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ.

Autor: Ebert SM; Departments of Internal Medicine and Molecular Physiology and Biophysics, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242; Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52246; Emmyon, Inc., Coralville, Iowa 52241., Bullard SA; Departments of Internal Medicine and Molecular Physiology and Biophysics, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242; Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52246., Basisty N; Buck Institute for Research on Aging, Novato, California 94945., Marcotte GR; Departments of Internal Medicine and Molecular Physiology and Biophysics, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242; Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52246., Skopec ZP; Departments of Internal Medicine and Molecular Physiology and Biophysics, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242; Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52246., Dierdorff JM; Departments of Internal Medicine and Molecular Physiology and Biophysics, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242; Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52246., Al-Zougbi A; Departments of Internal Medicine and Molecular Physiology and Biophysics, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242; Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52246., Tomcheck KC; Departments of Internal Medicine and Molecular Physiology and Biophysics, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242; Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52246., DeLau AD; Departments of Internal Medicine and Molecular Physiology and Biophysics, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242; Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52246., Rathmacher JA; Departments of Internal Medicine and Molecular Physiology and Biophysics, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242; Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52246., Bodine SC; Departments of Internal Medicine and Molecular Physiology and Biophysics, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242; Emmyon, Inc., Coralville, Iowa 52241., Schilling B; Buck Institute for Research on Aging, Novato, California 94945., Adams CM; Departments of Internal Medicine and Molecular Physiology and Biophysics, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242; Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52246; Emmyon, Inc., Coralville, Iowa 52241. Electronic address: christopher-adams@uiowa.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2020 Feb 28; Vol. 295 (9), pp. 2787-2803. Date of Electronic Publication: 2020 Jan 17.

β-hydroxybutyrate and ischemic stroke: roles and mechanisms.

Autor: Feng, Ge^1,2 (AUTHOR), Wu, Zongkai² (AUTHOR), Yang, Leyi^1,2 (AUTHOR), Wang, Kaimeng^1,2 (AUTHOR), Wang, Hebo^2,3 (AUTHOR) wanghbhope@hebmu.edu.cn

Publikováno v: Molecular Brain. 7/29/2024, Vol. 17 Issue 1, p1-16. 16p.