Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Marcos Sotomayor"'
Autor:
Maryna V. Ivanchenko, Daniel M. Hathaway, Alex J. Klein, Bifeng Pan, Olga Strelkova, Pedro De-la-Torre, Xudong Wu, Cole W. Peters, Eric M. Mulhall, Kevin T. Booth, Corey Goldstein, Joseph Brower, Marcos Sotomayor, Artur A. Indzhykulian, David P. Corey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Usher syndrome type 1 F (USH1F), caused by mutations in the protocadherin-15 gene (PCDH15), is characterized by congenital deafness, lack of balance, and progressive blindness. In hair cells, the receptor cells of the inner ear, PCDH15 is a
Externí odkaz:
https://doaj.org/article/7c07a295a0974ee8b332825242a40ad2
Autor:
Michelle E Gray, Zachary R Johnson, Debadrita Modak, Elakkiya Tamilselvan, Matthew J Tyska, Marcos Sotomayor
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001463 (2021)
Enterocytes are specialized epithelial cells lining the luminal surface of the small intestine that build densely packed arrays of microvilli known as brush borders. These microvilli drive nutrient absorption and are arranged in a hexagonal pattern m
Externí odkaz:
https://doaj.org/article/215bf8647f1b45f5ab50523fae5d7bc6
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Tip-link filaments convey force to activate hair cells, important sensory receptors. Here the authors solve a partial structure of human protocadherin-15, a tip-link component with an unusual Ca2+–free linker that bends and is predicted to confer f
Externí odkaz:
https://doaj.org/article/30a8a2d6da894b47aea927d90ea31194
Rounding Out the Understanding of ACD Toxicity with the Discovery of Cyclic Forms of Actin Oligomers
Autor:
Harper Smith, Nick Pinkerton, David B. Heisler, Elena Kudryashova, Aaron R. Hall, Kelly R. Karch, Andrew Norris, Vicki Wysocki, Marcos Sotomayor, Emil Reisler, Dimitrios Vavylonis, Dmitri S. Kudryashov
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 718 (2021)
Actin is an essential element of both innate and adaptive immune systems and can aid in motility and translocation of bacterial pathogens, making it an attractive target for bacterial toxins. Pathogenic Vibrio and Aeromonas genera deliver actin cross
Externí odkaz:
https://doaj.org/article/10e81224ddb74c48981066f227af3962
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189546 (2017)
Protein-protein interactions play a crucial role in biological processes such as cell-cell adhesion, immune system-pathogen interactions, and sensory perception. Understanding the structural determinants of protein-protein complex formation and obtai
Externí odkaz:
https://doaj.org/article/68d2cd0f041b41819f1a55a9525225ac
Publikováno v:
eLife, Vol 5 (2016)
Non-clustered δ-protocadherins are homophilic cell adhesion molecules essential for the development of the vertebrate nervous system, as several are closely linked to neurodevelopmental disorders. Mutations in protocadherin-19 (PCDH19) result in a f
Externí odkaz:
https://doaj.org/article/d092773098c34f049e3fbd4258890364
Autor:
Arnaud P. J. Giese, Wei-Hsiang Weng, Katie S Kindt, Vanessa H. H. Chang, Jonathan S Montgomery, Evan M. Ratzan, Alisha J. Beirl, Roberto Aponte Rivera, Jeffrey M. Lotthammer, Sanket Walujkar, Mark P. Foster, Omid A. Zobeiri, Jeffrey R. Holt, Saima Riazuddin, Kathleen E. Cullen, Marcos Sotomayor, Zubair M Ahmed
Publikováno v:
bioRxiv
Calcium and integrin-binding protein 2 (CIB2) and CIB3 bind to transmembrane channel-like 1 (TMC1) and TMC2, the pore-forming subunits of the inner-ear mechano-electrical transduction (MET) apparatus. Whether these interactions are functionally relev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a43260b3faad82ecf004cd3b46a544
https://europepmc.org/articles/PMC10312449/
https://europepmc.org/articles/PMC10312449/
Autor:
Collin R Nisler, Yoshie Narui, Emily Scheib, Deepanshu Choudhary, Jacob D Bowman, Harsha Mandayam Bharathi, Vincent J Lynch, Marcos Sotomayor
Publikováno v:
Molecular Biology and Evolution. 40
The sensory epithelium of the inner ear, found in all extant lineages of vertebrates, has been subjected to over 500 million years of evolution, resulting in the complex inner ear of modern vertebrates. Inner-ear adaptations are as diverse as the spe
Publikováno v:
Biophys J
Cadherin-based adherens junctions and desmosomes help stabilize cell-cell contacts with additional function in mechano-signaling, while clustered protocadherin junctions are responsible for directing neuronal circuits assembly. Structural models for
Publikováno v:
Biophysical Journal. 122:474a-475a