COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase

Autor: Shivatheja Soma, Marcos N. Morgada, Mandar T. Naik, Aren Boulet, Anna A. Roesler, Nathaniel Dziuba, Alok Ghosh, Qinhong Yu, Paul A. Lindahl, James B. Ames, Scot C. Leary, Alejandro J. Vila, Vishal M. Gohil

Publikováno v: Cell Reports, Vol 29, Iss 12, Pp 4114-4126.e5 (2019)

Summary: In eukaryotes, cellular respiration is driven by mitochondrial cytochrome c oxidase (CcO), an enzyme complex that requires copper cofactors for its catalytic activity. Insertion of copper into its catalytically active subunits, including COX

Externí odkaz: https://doaj.org/article/6322aed5c16a4dc79ccf348a0f9dc969

pH-Induced Binding of the Axial Ligand in an Engineered CuA Site Favors the πu State

Autor: Florencia Emiliani, Damián Alvarez-Paggi, Luciano A. Abriata, Alejandro J. Vila, Kelly N. Chacón, Daniel H. Murgida, Marcos N. Morgada, Ninian J. Blackburn

Publikováno v: Inorganic Chemistry. 58:15687-15691

CuA centers perform efficient long-range electron transfer. The electronic structure of native CuA sites can be described by a double-potential well with a dominant σu* ground state in fast equilibrium with a less populated πu ground state. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::840eb05aa0a7da380e093688c6329cd2
https://doi.org/10.1021/acs.inorgchem.9b01868

Purple Mixed-Valent Copper A

Autor: Marcos N, Morgada, Daniel H, Murgida, Alejandro J, Vila

Publikováno v: Metal ions in life sciences. 20

CuA is a binuclear copper center acting as an electron transfer hub in terminal oxidases such as cytochrome c oxidase and nitrous oxide reductase. Its unique electronic structure is intimately linked to its function and has puzzled the community of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08ce5f631f470d61d334dc4087923ea7
https://pubmed.ncbi.nlm.nih.gov/32851825

4. Purple Mixed-Valent Copper A

Autor: Alejandro J. Vila, Marcos N. Morgada, Daniel H. Murgida

CuA is a binuclear copper center acting as an electron transfer hub in terminal oxidases such as cytochrome c oxidase and nitrous oxide reductase. Its unique electronic structure is intimately linked to its function and has puzzled the community of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bced63f2e70e7a20638192ed2ca72f66
https://doi.org/10.1515/9783110589757-010

Unexpected electron spin density on the axial methionine ligand in Cu A suggests its involvement in electron pathways

Autor: Alejandro J. Vila, Daniel H. Murgida, María-Eugenia Llases, Estefanía Giannini, María-Natalia Lisa, Marcos N. Morgada, María A. Castro, Pedro M. Alzari

Publikováno v: Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2020, 56 (8), pp.1223-1226. ⟨10.1039/c9cc08883k⟩
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Chemical Communications, 2020, 56 (8), pp.1223-1226. ⟨10.1039/c9cc08883k⟩

The CuA center is a paradigm for the study of long-range biological electron transfer. This metal center is an essential cofactor for terminal oxidases like cytochrome c oxidase, the enzymatic complex responsible for cellular respiration in eukaryote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4b6c8756d542e6078ac4e28a120fe3
https://hal-pasteur.archives-ouvertes.fr/pasteur-03095789