Novel Decision Tool for More Severe α-Thalassemia Genotypes Screening with Functional Loss of Two or More α-Globin Genes: A Diagnostic Test Study

Autor: Patricia F. R. Siqueira, Marcos K. Fleury, Robéria M. Pontes, Renata S. P. Silva, Elaine S. Costa, Marcelo G. P. Land

Publikováno v: Diagnostics, Vol 12, Iss 12, p 3008 (2022)

After the exclusion of iron deficiency and β-thalassemia, molecular research for α-thalassemia is recommended to investigate microcytic anemia. Aiming to suggest more efficiently the molecular analysis for individuals with a greater chance of havin

Externí odkaz: https://doaj.org/article/9210fc7f7f87433a8596985996853cf0

Triagem de hemoglobinopatias e avaliação da degeneração oxidativa da hemoglobina em trabalhadores portadores do traço falciforme (HbAS), expostos a riscos ocupacionais Screening of abnormal hemoglobin and the evaluation of oxidative degeneration of hemoglobin among workers with the sickle cell trait (HbAS), exposed to occupational hazards

Autor: Isaac L. Silva Filho, Marilda S. Gonçalves, Elisângela V. Adôrno, Dayse P. Campos, Marcos K. Fleury

Publikováno v: Revista Brasileira de Hematologia e Hemoterapia, Vol 27, Iss 3, Pp 183-187 (2005)

Desde os anos 40, quando foram realizados os primeiros trabalhos de triagem para hemoglobinas anormais na população brasileira, tem sido descrita uma elevada prevalência destas em nosso meio, especialmente a hemoglobina S que, a despeito da hetero

Externí odkaz: https://doaj.org/article/1a6dc50435294c039fc889fe1ca5dc2d

Determinação dos haplótipos do gene da globina beta em pacientes com anemia falciforme do Rio de Janeiro

Autor: Marcos K. Fleury

Publikováno v: Revista Brasileira de Hematologia e Hemoterapia, Vol 23, Iss 1, Pp 57-58 (2001)

Externí odkaz: https://doaj.org/article/c8ce93c5726b4003acc39b6cbfaf7d1f

Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST

Autor: José Roberto Lapa e Silva, Luciane de Souza Velasque, José Carlos Saraiva Gonçalves, Martha Maria Oliveira, Eliana Abreu Santos, Afrânio Lineu Kritski, Rita de Cássia Elias Estrela, Marcos K. Fleury

Publikováno v: Brazilian Journal of Infectious Diseases v.23 n.6 2019
Brazilian Journal of Infectious Diseases
Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
Brazilian Journal of Infectious Diseases, Vol 23, Iss 6, Pp 381-387 (2019)
Brazilian Journal of Infectious Diseases, Volume: 23, Issue: 6, Pages: 381-387, Published: 14 FEB 2020

Setting: Treatment of tuberculosis (TB) can result in Drug-Induced Liver Injury (DILI) since hepatotoxic metabolites are formed during the biotransformation of isoniazid (INH).DILI can be related to the genetic profile of the patient. Single nucleoti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4564eef106e2f5825a2c4db56aabcba
https://doi.org/10.1016/j.bjid.2019.09.003

Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease

Autor: Elaine Sobral da Costa, Andrea Soares, Maria Christina Paixão Maioli, Liliane R. Alves, Patrícia F R Siqueira, Isaac L. Silva Filho, Fabiana V. Mello, Marcos K. Fleury, Marcelo Gerardin Poirot Land, Jussara Fonseca Fernandes de Medeiros, Roberia Pontes

Publikováno v: Hematology. 22:444-449

Objectives: Cholecystitis is one of the complications of symptomatic cholelithiasis responsible for high levels of morbidity of sickle cell disease (SCD) patients. Here, we investigated the possible protective role of single gene deletions of α-thal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0926ae28e32dd398656f81c96084dad
https://doi.org/10.1080/10245332.2017.1289325