Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Marcos J. Guerrero-Muñoz"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
The conversion and transmission of misfolded proteins established the basis for the prion concept. Neurodegenerative diseases are considered “prion-like” disorders that lack infectivity. Among them, tauopathies are characterized by the conversion
Externí odkaz:
https://doaj.org/article/72d7ffaa19c54038a2398e1c629fd6a4
Autor:
Marcos J. Guerrero-Muñoz, Diana L. Castillo-Carranza, Shashirekha Krishnamurthy, Adriana A. Paulucci-Holthauzen, Urmi Sengupta, Cristian A. Lasagna-Reeves, Yembur Ahmad, George R. Jackson, Rakez Kayed
Publikováno v:
Neurobiology of Disease, Vol 71, Iss , Pp 14-23 (2014)
Alzheimer's disease is a complex disease characterized by overlapping phenotypes with different neurodegenerative disorders. Oligomers are considered the most toxic species in amyloid pathologies. We examined human AD brain samples using an anti-olig
Externí odkaz:
https://doaj.org/article/ad0b5336be6e4bf6ab2bfdd5adb88c0b
Autor:
Cristian A Lasagna-Reeves, Maxime WC Rousseaux, Marcos J Guerrero-Muñoz, Jeehye Park, Paymaan Jafar-Nejad, Ronald Richman, Nan Lu, Urmi Sengupta, Alexandra Litvinchuk, Harry T Orr, Rakez Kayed, Huda Y Zoghbi
Publikováno v:
eLife, Vol 4 (2015)
Recent studies indicate that soluble oligomers drive pathogenesis in several neurodegenerative proteinopathies, including Alzheimer and Parkinson disease. Curiously, the same conformational antibody recognizes different disease-related oligomers, des
Externí odkaz:
https://doaj.org/article/50bd66d718644c13ad6bb20b07f4c12d
Autor:
Rakez Kayed, Urmi Sengupta, Nemil Bhatt, Marcos J. Guerrero-Muñoz, Daniel V. Cantu, Gaurav Ghag, Anna Ellsworth
Publikováno v:
Protein Science. 27:1901-1909
Several studies have proposed that fibrillary aggregates of tau and other amyloidogenic proteins are neurotoxic and result in numerous neurodegenerative diseases. However, these studies usually involve sonication or extrusion through needles before e
Autor:
Marcos J. Guerrero-Muñoz, Diana L. Castillo-Carranza, Caterina M. Hernandez, Urmi Sengupta, Kelly T. Dineley, Alan D.T. Barrett, Rakez Kayed
Publikováno v:
The Journal of Neuroscience. 35:4857-4868
In Alzheimer's disease (AD), the pathological accumulation of tau appears to be a downstream effect of amyloid β protein (Aβ). However, the relationship between these two proteins and memory loss is unclear. In this study, we evaluated the specific
Autor:
Urmi Sengupta, Rakez Kayed, Adriana A. Paulucci-Holthauzen, Yembur Ahmad, Cristian A. Lasagna-Reeves, Shashirekha Krishnamurthy, Diana L. Castillo-Carranza, Marcos J. Guerrero-Muñoz, George R. Jackson
Publikováno v:
Neurobiology of Disease, Vol 71, Iss, Pp 14-23 (2014)
Alzheimer's disease is a complex disease characterized by overlapping phenotypes with different neurodegenerative disorders. Oligomers are considered the most toxic species in amyloid pathologies. We examined human AD brain samples using an anti-olig
Autor:
Urmi Sengupta, Diana L. Castillo-Carranza, Marcos J. Guerrero-Muñoz, Julia E. Gerson, Rakez Kayed
Publikováno v:
Biological psychiatry
Background The coexistence of α-synuclein and tau aggregates in several neurodegenerative disorders, including Parkinson’s disease and Alzheimer’s disease, raises the possibility that a seeding mechanism is involved in disease progression. Metho
Publikováno v:
Frontiers in Aging Neuroscience
Aging has long been considered as the main risk factor for several neurodegenerative disorders including a large group of diseases known as tauopathies. Even though neurofibrillary tangles (NFTs) have been examined as the main histopathological hallm
Autor:
Gurpreet Singh, George R. Jackson, D. Mark Estes, Urmi Sengupta, Julia E. Gerson, Kelly T. Dineley, Diana L. Castillo-Carranza, Alan D.T. Barrett, Cristian A. Lasagna-Reeves, Marcos J. Guerrero-Muñoz, Rakez Kayed
Publikováno v:
The Journal of Neuroscience. 34:4260-4272
Recent findings suggest that tau oligomers, which form before neurofibrillary tangles (NFTs), are the true neurotoxic tau entities in neurodegenerative tauopathies, including Alzheimer's disease (AD). Studies in animal models of tauopathy suggest tha
Autor:
Rakez Kayed, Diana L. Castillo-Carranza, Urmi Sengupta, Audra L. Clos, Cristian A. Lasagna-Reeves, Brent Kelly, Marcos J. Guerrero-Muñoz, Richard F. Wagner
Publikováno v:
Biochemical and Biophysical Research Communications. 430:963-968
The tumor suppressor p53 plays an important role in genome integrity. It is frequently mutated in all types of human cancers, making p53 a key factor in cancer progression. Two phenotypic consequences of these alterations are dominant; a loss of func