Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Marcos Hikari Toyama"'
Autor:
Vitoria Isabela Montanhero Cabrera, Gabrielle do Nascimento Sividanes, Natalia Fernanda Quintiliano, Marcos Hikari Toyama, João Henrique Ghilardi Lago, Marcos Antonio de Oliveira
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281322 (2023)
Multiple drug resistance (MDR) bacterial strains are responsible by 1.2 million of human deaths all over the world. The pathogens possess efficient enzymes which are able to mitigate the toxicity of reactive oxygen species (ROS) produced by some anti
Externí odkaz:
https://doaj.org/article/ca6c114db09e4fba9f3d626403f860ca
Autor:
Mariana Novo Belchor, Caroline Ramos da Cruz Costa, Airam Roggero, Laila L. F. Moraes, Ricardo Samelo, Isabelly Annunciato, Marcos Antonio de Oliveira, Sergio F. Sousa, Marcos Hikari Toyama
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 597 (2023)
Quercetin derivatives have already shown their anti-inflammatory potential, inhibiting essential enzymes involved in this process. Among diverse pro-inflammatory toxins from snake venoms, phospholipase A2 is one of the most abundant in some species,
Externí odkaz:
https://doaj.org/article/5fc3cdf7dabb4e4683cba14d428a3089
Autor:
Larissa Valle Guilhen Longo, Carlos Alexandre Breyer, Gabriela Machado Novaes, Gregory Gegembauer, Natanael Pinheiro Leitão, Carla Elizabete Octaviano, Marcos Hikari Toyama, Marcos Antonio de Oliveira, Rosana Puccia
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Paracoccidioides brasiliensis is a temperature-dependent dimorphic fungus that causes systemic paracoccidioidomycosis, a granulomatous disease. The massive production of reactive oxygen species (ROS) by the host's cellular immune response is an essen
Externí odkaz:
https://doaj.org/article/ec42907d15ab44dbb5f6cafa9721e5af
Autor:
Caroline Fabri Bittencourt Rodrigues, Caroline Serino-Silva, Karen de Morais-Zani, Victor Koiti Kavazoi, Marcelo Pires Nogueira Carvalho, Kathleen Fernandes Grego, Tassia Chiarelli, Alexandre Keiji Tashima, Marcos Hikari Toyama, Anita Mitico Tanaka-Azevedo
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229657 (2020)
Plasma in several organisms has components that promote resistance to envenomation by inhibiting specific proteins from snake venoms, such as phospholipases A2 (PLA2s). The major hypothesis for inhibitor's presence would be the protection against sel
Externí odkaz:
https://doaj.org/article/b34c8e30137248039b84fd574defeffa
Autor:
Marcos Hikari Toyama, Airam Rogero, Laila Lucyane Ferreira de Moraes, Gustavo Antônio Fernandes, Caroline Ramos da Cruz Costa, Mariana Novo Belchor, Agatha Manzi De Carli, Marcos Antônio de Oliveira
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 368 (2022)
(1) Background: Gallic acid (GA) has been characterized as an effective anti-inflammatory, antivenom, and promising drug for therapeutic use. (2/3) Methods and Results: GA was identified from ethanolic extract of fresh pitanga (Eugenia uniflora) leav
Externí odkaz:
https://doaj.org/article/cb895ccde8574c63b3ee7f1c01dbe4a7
Autor:
Leonardo Mendes de Souza Mesquita, Caroline Fabri Bittencourt Rodrigues, Cláudia Quintino da Rocha, Mayara Silveira Bianchim, Clenilson Martins Rodrigues, Vanda Maria de Oliveira, Henrique Hessel Gaeta, Mariana Novo Belchor, Marcos Hikari Toyama, Wagner Vilegas
Publikováno v:
Natural Products and Bioprospecting, Vol 9, Iss 1, Pp 23-34 (2018)
Abstract We recognize the chemical composition of the acetonic extract of Rhizophora mangle barks (AERM) using mass spectrometry analysis [liquid chromatography (LC)–ESI–IT-MS/MS and matrix-assisted laser desorption/ionization-time of flight-MS (
Externí odkaz:
https://doaj.org/article/d0543d2fbe2f450c8553d2c85c94045d
Autor:
Carlos A. Tairum, Melina Cardoso Santos, Carlos Alexandre Breyer, Ana Laura Pires de Oliveira, Vitoria Isabela Montanhero Cabrera, Guilherme Toledo-Silva, Gustavo Maruyama Mori, Marcos Hikari Toyama, Luis Eduardo Soares Netto, Marcos Antonio de Oliveira
Publikováno v:
Antioxidants, Vol 10, Iss 7, p 1032 (2021)
Typical 2-Cys peroxiredoxins (2-Cys Prx) are ubiquitous Cys-based peroxidases, which are stable as decamers in the reduced state, and may dissociate into dimers upon disulfide bond formation. A peroxidatic Cys (CP) takes part of a catalytic triad, to
Externí odkaz:
https://doaj.org/article/f8b742f6bdfe48deaedab6dc8bf98611
Autor:
Adeilso Bispo dos Santos Junior, Cinthia I. Tamayose, Marcelo J. P. Ferreira, Mariana N. Belchor, Caroline R. C. Costa, Marcos Antonio de Oliveira, Marcos Hikari Toyama
Publikováno v:
Molecules, Vol 25, Iss 2, p 282 (2020)
Bioaffinity capturing of molecules allows the discovery of bioactive compounds and decreases the need for various stages in the natural compound isolation process. Despite the high selectivity of this technique, the screening and identification metho
Externí odkaz:
https://doaj.org/article/88d3e4de808541749c5a053b6b55a246
Autor:
Caroline Serino-Silva, Karen Morais-Zani, Marcos Hikari Toyama, Daniela de Oliveira Toyama, Henrique Hessel Gaeta, Caroline Fabri Bittencourt Rodrigues, Wéslei da Silva Aguiar, Alexandre Keiji Tashima, Kathleen Fernandes Grego, Anita Mitico Tanaka-Azevedo
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193105 (2018)
Phospholipases A2 (PLA2) are enzymes acting on the cell membrane phospholipids resulting in fatty acids and lysophospholipids and deconstructing the cell membrane. This protein is commonly found in snake venoms, causing tissue inflammation in the aff
Externí odkaz:
https://doaj.org/article/29c81f3775464ed398fc2ca96bf2b1e5
Autor:
Caroline Fabri Bittencourt Rodrigues, Henrique Hessel Gaeta, Mariana Novo Belchor, Marcelo José Pena Ferreira, Marcus Vinícius Terashima Pinho, Daniela de Oliveira Toyama, Marcos Hikari Toyama
Publikováno v:
Marine Drugs, Vol 13, Iss 7, Pp 4505-4519 (2015)
The aim of this work was to verify the effects of methanol (MeOH) and hydroalcoholic (HA) extracts and their respective partition phases obtained from white mangrove (Laguncularia racemosa (L.) C.F. Gaertn.) leaves on human thrombin activity. Among t
Externí odkaz:
https://doaj.org/article/426a179ac0a74fe1b68d639c97e2e306