Sepsis-induced immunosuppression is marked by an expansion of a highly suppressive repertoire of FOXP3+ T-regulatory cells expressing TIGIT

Autor: Fernando Q. Cunha, Carlos W. S. Wanderley, Carlos Hiroji Hiroki, Camilla Meireles S Silva, Augusto V. Gonçalves, Gustavo Fernando da Silva Quirino, Guilherme Cesar Martelossi Cebinelli, Marcos Henrique Rosa, Thiago M. Cunha, Dario S. Zamboni, Jessica Adrielle Teixeira Santos, José-Carlos A Filho, Mikhael Haruo Fernandes de Lima, Vanessa F. Borges

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background Although the literature shows that an increase in both the number and suppressive function of CD4+forkhead box P3 (FOXP3)+ T-regulatory cells (Tregs) during sepsis contributes to an immunosuppressed state, little is known about the identit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003a7d4437cf84e89e63682a8fd123f0

PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation

Autor: Marcos Henrique Rosa, Miriam M. Fonseca, Juliana E Toller-Kawahisa, Fernando Silva Ramalho, Douglas Silva Prado, Gabriel Azevedo Publio, Timna Varela Martins, Luis Eduardo Alves Damasceno, Flávio P. Veras, Thiago M. Cunha, Ari Waisman, José C. Alves-Filho, Fernando Q. Cunha

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The Journal of Experimental Medicine

Th17 cells undergo metabolic reprogramming towards glycolysis to support their differentiation and pathogenicity. Damasceno et al. report that PKM2, a glycolytic enzyme, plays a nonmetabolic role in mediating Th17 cell differentiation and autoimmune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12f2ab9db134e467d692b04f68aa564
https://doi.org/10.1084/jem.20190613

Potential use of CXCL12/CXCR4 and sonic hedgehog pathways as therapeutic targets in medulloblastoma

Autor: Igor Alves Mancilla, Maria Angelica Ehara Watanabe, Marcos Henrique Rosa, Glauco Akelinghton Freire Vitiello, Marla Karine Amarante

Publikováno v: Acta oncologica (Stockholm, Sweden). 57(9)

Medulloblastoma (MB) is the most common malignant brain tumor occurring in children, and although high long-term survival rates have been reached with current therapeutic protocols, several neurological injuries are still observed among survivors. It

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2653ddaad4c2326bf47b2dcfefb72e09
https://pubmed.ncbi.nlm.nih.gov/29771176