Biomimetic Proteoglycans Strengthen the Pericellular Matrix of Normal and Osteoarthritic Human Cartilage.

Autor: Kahle ER; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States., Fallahi H; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States., Bergstrom AR; Department of Chemical and Biological Engineering, Villanova University, Villanova, Pennsylvania 19085, United States., Li A; Department of Mechanical Engineering, Villanova University, Villanova, Pennsylvania 19085, United States., Trouillot CE; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States., Mulcahey MK; Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, Illinois 60153, United States., Lu XL; Department of Mechanical Engineering, University of Delaware, Newark, Delaware 19716, United States., Han L; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States., Marcolongo MS; Department of Mechanical Engineering, Villanova University, Villanova, Pennsylvania 19085, United States.

Publikováno v: ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2024 Sep 09; Vol. 10 (9), pp. 5617-5623. Date of Electronic Publication: 2024 Aug 12.

Targeting cell-matrix interface mechanobiology by integrating AFM with fluorescence microscopy.

Autor: Kahle ER; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States., Patel N; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States., Sreenivasappa HB; Cell Imaging Center, Office of Research and Innovation, Drexel University, PA 19104, United States., Marcolongo MS; Department of Mechanical Engineering, Villanova University, Villanova, PA 19085, United States., Han L; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States. Electronic address: lh535@drexel.edu.

Publikováno v: Progress in biophysics and molecular biology [Prog Biophys Mol Biol] 2022 Dec; Vol. 176, pp. 67-81. Date of Electronic Publication: 2022 Aug 30.

Type III collagen is a key regulator of the collagen fibrillar structure and biomechanics of articular cartilage and meniscus.

Autor: Wang C; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States., Brisson BK; Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, 19104, United States., Terajima M; Division of Oral and Craniofacial Health Sciences, University of North Carolina, Chapel Hill, NC, 27599, United States., Li Q; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States., Hoxha K; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States., Han B; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States., Goldberg AM; Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, 19104, United States., Sherry Liu X; McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States., Marcolongo MS; Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, 19104, United States., Enomoto-Iwamoto M; Department of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD, 21201, United States., Yamauchi M; Division of Oral and Craniofacial Health Sciences, University of North Carolina, Chapel Hill, NC, 27599, United States., Volk SW; Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, 19104, United States. Electronic address: swvolk@vet.upenn.edu., Han L; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States. Electronic address: lh535@drexel.edu.

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2020 Jan; Vol. 85-86, pp. 47-67. Date of Electronic Publication: 2019 Oct 23.

Biomimetic proteoglycans diffuse throughout articular cartilage and localize within the pericellular matrix.

Autor: Phillips ER; Department of Materials Science and Engineering, College of Engineering, Drexel University, Philadelphia, Pennsylvania., Haislup BD; College of Medicine, Drexel University, Philadelphia, Pennsylvania., Bertha N; College of Medicine, Drexel University, Philadelphia, Pennsylvania., Lefchak M; Department of Materials Science and Engineering, College of Engineering, Drexel University, Philadelphia, Pennsylvania., Sincavage J; School of Biomedical Engineering, Drexel University, Philadelphia, Pennsylvania., Prudnikova K; Department of Materials Science and Engineering, College of Engineering, Drexel University, Philadelphia, Pennsylvania., Shallop B; Department of Orthopaedic Surgery, Drexel University College of Medicine/Hahnemann University Hospital, Philadelphia, Pennsylvania., Mulcahey MK; Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, Louisiana., Marcolongo MS; Department of Materials Science and Engineering, College of Engineering, Drexel University, Philadelphia, Pennsylvania.

Publikováno v: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2019 Sep; Vol. 107 (9), pp. 1977-1987. Date of Electronic Publication: 2019 May 22.

Biomimetic proteoglycans can molecularly engineer early osteoarthritic cartilage in vivo.

Autor: Phillips ER; Department of Materials Science and Engineering, College of Engineering, Drexel University, 3141 Chestnut St, Philadelphia, Pennsylvania, 19104., Prudnikova K; Department of Materials Science and Engineering, College of Engineering, Drexel University, 3141 Chestnut St, Philadelphia, Pennsylvania, 19104., Bui T; College of Medicine, Drexel University, 2900 W Queen Lane, Philadelphia, Pennsylvania, 19129., Taylor AJ; College of Medicine, Drexel University, 2900 W Queen Lane, Philadelphia, Pennsylvania, 19129., Galindo DA; Philadelphia College of Osteopathic Medicine, 4170 City Line Avenue, Philadelphia, Pennsylvania, 19131., Huneke RB; Department of Microbiology and Immunology, College of Medicine, Drexel University, 245 N 15th Street, Philadelphia, Pennsylvania, 19102., Hou JS; Department of Pathology and Laboratory Medicine, College of Medicine, Drexel University, 245 North 15th Street, Philadelphia, Pennsylvania, 19102., Mulcahey MK; Department of Orthopaedic Surgery, Tulane University School of Medicine, 1430 Tulane Avenue Box 8632 Box 8632, New Orleans, Louisiana, 70112., Marcolongo MS; Department of Materials Science and Engineering, College of Engineering, Drexel University, 3141 Chestnut St, Philadelphia, Pennsylvania, 19104.

Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2019 Feb; Vol. 37 (2), pp. 403-411. Date of Electronic Publication: 2019 Jan 03.