The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma models.

Autor: de la Nava D; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Ausejo-Mauleon I; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Laspidea V; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Gonzalez-Huarriz M; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Lacalle A; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Casares N; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Zalacain M; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Marrodan L; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., García-Moure M; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Ochoa MC; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Tallon-Cobos AC; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Hernandez-Osuna R; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Marco-Sanz J; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Dhandapani L; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Hervás-Corpión I; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Becher OJ; Jack Martin Fund Division of Pediatric Hematology-oncology, Mount Sinai, New York, USA., Nazarian J; Division of Oncology and Children's Research Center, DIPG/DMG Research Center Zurich, University Children's Hospital Zurich, Zurich, Switzerland.; Virginia Tech University, Washington, District of Columbia, USA.; Children's National Health System, Center for Genetic Medicine Research, Washington, District of Columbia, USA., Mueller S; University of California, San Francisco San Francisco, California, USA.; Division of Oncology and Children's Research Center, DIPG/DMG Research Center Zurich, University Children's Hospital Zurich, Zurich, Switzerland., Phoenix TN; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA., van der Lugt J; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Hernaez M; Bioinformatics Platform, Center for Applied Medical Research, University of Navarra (CIMA), Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Guruceaga E; Bioinformatics Platform, Center for Applied Medical Research, University of Navarra (CIMA), Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Koschmann C; Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA., Venneti S; Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA., Allen JE; Chimerix, Inc. Durham, North Carolina, USA., Dun MD; Paediatric Stream, Mark Hughes Foundation Centre for Brain Cancer Research, College of Health, Medicine, and Wellbeing, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia., Fueyo J; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Gomez-Manzano C; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Gallego Perez-Larraya J; Department of Neurology, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Patiño-García A; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Labiano S; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain., Alonso MM; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Spain.; Health Research Institute of Navarra (IdiSNA), Pamplona, Spain.

Publikováno v: Neuro-oncology [Neuro Oncol] 2024 Aug 05; Vol. 26 (8), pp. 1509-1525.

Set Protein Is Involved in FLT3 Membrane Trafficking.

Autor: Marcotegui N; Centro de Investigación Médica Aplicada (CIMA), University of Navarra, 31008 Pamplona, Spain., Romero-Murillo S; Centro de Investigación Médica Aplicada (CIMA), University of Navarra, 31008 Pamplona, Spain.; Department of Biochemistry and Genetics, University of Navarra, 31008 Pamplona, Spain., Marco-Sanz J; Centro de Investigación Médica Aplicada (CIMA), University of Navarra, 31008 Pamplona, Spain., Peris I; Centro de Investigación Médica Aplicada (CIMA), University of Navarra, 31008 Pamplona, Spain.; Department of Biochemistry and Genetics, University of Navarra, 31008 Pamplona, Spain.; Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain., Berrozpe BS; Centro de Investigación Médica Aplicada (CIMA), University of Navarra, 31008 Pamplona, Spain., Vicente C; Centro de Investigación Médica Aplicada (CIMA), University of Navarra, 31008 Pamplona, Spain.; Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain., Odero MD; Centro de Investigación Médica Aplicada (CIMA), University of Navarra, 31008 Pamplona, Spain.; Department of Biochemistry and Genetics, University of Navarra, 31008 Pamplona, Spain.; Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain.; Centro de Investigación Biomédica en Red Cancer (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain., Arriazu E; Centro de Investigación Médica Aplicada (CIMA), University of Navarra, 31008 Pamplona, Spain.; Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain.; Centro de Investigación Biomédica en Red Cancer (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Publikováno v: Cancers [Cancers (Basel)] 2023 Apr 10; Vol. 15 (8). Date of Electronic Publication: 2023 Apr 10.

Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas.

Autor: Laspidea V; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain., Puigdelloses M; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain., Labiano S; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain., Marrodán L; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain., Garcia-Moure M; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain., Zalacain M; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain., Gonzalez-Huarriz M; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain., Martínez-Vélez N; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain., Ausejo-Mauleon I; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain., de la Nava D; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain., Herrador-Cañete G; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Gene Therapy and Regulation of Gene Expression Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain., Marco-Sanz J; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain., Guruceaga E; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Bioinformatics Platform, El Centro de Investigación Médica Aplicada (CIMA), University of Navarra, Pamplona, Spain., de Andrea CE; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Department of Pathology, Navarra University Clinic, Pamplona, Spain., Villalba M; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Department of Pathology, Navarra University Clinic, Pamplona, Spain., Becher O; Department of Pediatrics.; Department of Biochemistry and Molecular Genetics, and.; Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA.; Division of Hematology Oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois, USA., Squatrito M; Seve Ballesteros Foundation Brain Tumor Group, Molecular Oncology Programme, Spanish National Cancer Research Center, Madrid, Spain., Matía V; Seve Ballesteros Foundation Brain Tumor Group, Molecular Oncology Programme, Spanish National Cancer Research Center, Madrid, Spain., Gállego Pérez-Larraya J; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Neurology, Navarra University Clinic, Pamplona, Spain., Patiño-García A; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain., Gupta S; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Gomez-Manzano C; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Fueyo J; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Alonso MM; Health Research Institute of Navarra, Pamplona, Navarra, Spain.; Solid Tumor Program, Center for the Applied Medical Research, Pamplona, Navarra, Spain.; Department of Pediatrics, Navarra University Clinic, Pamplona, Spain.

Publikováno v: JCI insight [JCI Insight] 2022 Apr 08; Vol. 7 (7). Date of Electronic Publication: 2022 Apr 08.

Importance of PTM of FLT3 in acute myeloid leukemia.

Autor: Jianwei Liu, Jianguo Gu

Publikováno v: Acta Biochimica et Biophysica Sinica; 8/15/2024, Vol. 56 Issue 8, p1199-1207, 9p