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pro vyhledávání: '"Marco alpegiani"'
A solid DMSO salvate of a compound of fornula (I) is described, which is a useful intemediate far preparing the broad spectrum antibiotics Ceftobiprole and Ceftobiprole Medocaril.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4094::06b18b99cbe2eb2f3a7d5a3a63fb4021
http://hdl.handle.net/11585/767799
http://hdl.handle.net/11585/767799
Publikováno v:
Organic Process Research & Development. 11:64-72
The ongoing patent battle relating to Cefdinir polymorphism and crystalline forms is described from a scientific point of view. This case study illustrates some of the strategies adopted by generic bulk manufacturers to challenge originator's patents
Autor:
Piera Fonte, Walter Cabri, Elio Mapelli, Paolo Paissoni, Simonetta Songia, Sara Olmo, Jacopo Roletto, Paolo Ghetti, Marco Alpegiani
Publikováno v:
Organic Process Research & Development. 10:198-202
The development of a high-yield and low environmental impact synthesis able to deliver highly pure pergolide mesylate 1 is described. The process [seven chemical steps (four telescoped), three steps of isolation of intermediate, and only one drying]
Autor:
Marco Alpegiani, Daniela Borghi, Angelo Albini, Elisa Fasani, Stefano Del Nero, Ettore Perrone
Publikováno v:
Tetrahedron Letters. 36:4633-4636
The dioxolenonemethyl moiety of the oral penem prodrug FCE 25199 ( 1 ) was found to be a source of photochemical lability in the solid state. Reactions centered on the formation and decomposition of a hydroperoxide ( 3 ) have been observed and ration
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:691-694
Thieno- and pyrrolo[3,4-c]cepham sulfones were synthesized and compared to their furo analogs for activity as human leukocyte elastase inhibitors. Pyrrolo derivatives, especially when N-alkylated, combined excellent hydrolytic stability with remarkab
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:687-690
Furo[3,4-c]cepham sulfones were efficiently obtained from 1,1-dioxo-3-methylcephem-4-ketones. Cyclization improved at one time stability of the β-lactam towards hydrolytic cleavage (pH 7.4) and reactivity (second-order inhibition rate constant kon)
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2265-2270
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2259-2264
Interaction of elastase with 7α-methoxycephem sulfones has been investigated by a combination of HPLC and 1 H NMR methods. Products arising from enzymatic cleavage have been characterized; observed events were opening of the β-lactam ring, decarbox
Autor:
Ettore Perrone, Costantino Della Bruna, Bianca Patrizia Andreini, Rosaria Rossi, Franco Zarini, Giovanni Franceschi, Giuseppina Visentin, Marco Alpegiani, Daniela Jabes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2165-2170
The activity of penems against methicillin-resistant Staphylococcus aureus (MRSA) was determined on strains representative of the four expression classes of resistance. Two families of compounds, characterized by a C2-(hetero)aromatic moiety connecte
Publikováno v:
Canadian Journal of Chemistry. 71:1407-1411
N-Substituted 3-amino-1,4-butyrolactones undergo highly stereocontrolled substitution reactions via anionic and free radical processes.