Výsledky vyhledávání - "Marco Zaffaroni"

Management of antithrombotic therapy in gray areas of venous thromboembolism: a Delphi consensus panel

Autor: Rossana Orabona, Giovanni Barillari, Marco Zaffaroni, Edoarda Pacetti, Edoardo Sciatti, Francesco Dentali, Cristiano Bortoluzzi, Mauro Giorgi

For some years now, direct-acting oral anticoagulants (DOACs) have entered the clinical practice for stroke prevention in non-valvular atrial fibrillation (NVAF) or for prevention and treatment of venous thromboembolism (VTE). However, there is uncer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4262f067b8881a03d8cf1da9e70df0cd
http://hdl.handle.net/11383/2123944

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Pharmacokinetics and Metabolism in Mice of IDN 5390 (13-(N-Boc-3-i-butylisoserinoyl)-C-7,8-seco-10-deacetylbaccatin III), a New Oral C-seco-Taxane Derivative with Antiangiogenic Property Effective on Paclitaxel-Resistant Tumors

Autor: Roberta Frapolli, Carla Manzotti, Paolo Morazzoni, Cristiano Falcioni, Renzo Bagnati, Matteo Simone, Maurizio D'Incalci, Tina Colombo, Gabriele Fontana, Massimo Zucchetti, Marco Zaffaroni, Elena Marangon

Publikováno v: Drug Metabolism and Disposition. 34:2028-2035

IDN 5390 (13-(N-Boc-3-i-butylisoserinoyl)-C-7,8-seco-10-deacetylbaccatin III) is a new taxane, derived from 7,8-C-seco-10-deacetylbaccatin, selected for its ability to inhibit angiogenesis, mainly by acting on endothelial cell motility, and for its s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6774892ba96e854fbeb4a0aedb9ba94
https://doi.org/10.1124/dmd.106.012153

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Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma

Autor: Massimo Zucchetti, Andreas J. Gescher, Jose Jimeno, Tina Colombo, Marco Zaffaroni, Sarah Donald, Cristiano Falcioni, William P. Steward, Richard D. Verschoyle, Margaret M. Manson, Peter Greaves, Maurizio D'Incalci

Publikováno v: International Journal of Cancer. 111:961-967

ET-743, an experimental antitumor drug with promising activity in sarcoma, breast and ovarian carcinoma, is currently under phase 2 clinical evaluation. It is hepatotoxic in animals and patients. We tested the hypothesis that indole-3-carbinol (I3C),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedd8ddb195a2b0f5f7553100c898f3c
https://doi.org/10.1002/ijc.20356

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High-performance liquid chromatographic assay for the determination of the novel C-Seco-taxane derivative (IDN 5390) in mouse plasma

Autor: Maurizio D'Incalci, Robert Fruscio, Ezio Bombardelli, Roberta Frapolli, Paolo Morazzoni, Massimo Zucchetti, Tina Colombo, Marco Zaffaroni, Antonella Riva

Publikováno v: Journal of Chromatography B. 780:93-98

A HPLC assay was developed to determine IDN 5390, a new paclitaxel analogue, in mouse plasma. The method involves solid-phase extraction from cyano cartridges (recovery >80%), HPLC separation on Symmetry C(18) (4.6 x 150 mm), on isocratic mobile phas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2586884e8a984649b15799525c0ec0e
https://doi.org/10.1016/s1570-0232(02)00436-1

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High-performance liquid chromatographic assay for the determination of Aloe Emodin in mouse plasma

Autor: Teresa Pecere, Giuseppe Zagotto, Maurizio D'Incalci, Marco Zaffaroni, Massimo Zucchetti, C. Mucignat, Roberta Frapolli

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 796(1)

An isocratic high-performance liquid chromatography (HPLC) method was developed and validated to determine Aloe Emodin (AE) in mouse plasma. The analysis required 0.3 ml of plasma and involves extraction with dichloromethane. The HPLC separation was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f28b963d0cd8b0939316ff711ab948
https://pubmed.ncbi.nlm.nih.gov/14552822

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Fetal bovine serum, but not human serum, inhibits the in vitro cytotoxicity of ET-743 (Yondelis, trabectedin), an example of potential problems for extrapolation of active drug concentrations from in vitro studies

Autor: Glynn Faircloth, Maurizio D'Incalci, Marco Zaffaroni, Eugenio Erba, Roberta Frapolli, Massimo Zucchetti, Gianluca Tognon

Publikováno v: Cancer chemotherapy and pharmacology. 53(1)

a 80The first studies to assess the biological activity of new anticancer drugs are usually done on tumor cells growing in vitro. The concentrations of the test compound that inhibit g rowth and cause cytotoxici ty are calculated using a series o f t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cb460795724825d91b36c84ff0670b
https://pubmed.ncbi.nlm.nih.gov/14586558

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Effective combination of ET-743 and doxorubicin in sarcoma: preclinical studies

Autor: Riccardo Riccardi, Jimeno Jose, Anna Riccardi, Glynn Faircloth, Marco Zaffaroni, Maurizio D'Incalci, Massimo Zucchetti, Tina Colombo, Paolo Ubezio, Daniela Meco

To investigate the cytotoxic and antitumor effects of the combination of the novel anticancer drug ET-743 and doxorubicin (Dx) and to determine whether any pharmacokinetic interaction occurs in sarcoma-bearing mice. The cytotoxicity of each drug and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca44339b88438224d9685c9373b88e54
http://hdl.handle.net/10807/19470

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A novel taxane active against an orthotopically growing human glioma xenograft

Autor: Eugenio Scanziani, Silvia Veneroni, Ezio Bombardelli, Diletta Laccabue, Paola Perego, Franco Zunino, Massimo Zucchetti, Graziella Pratesi, Maurizio D'Incalci, Marco Zaffaroni, Monica Tortoreto

Publikováno v: Cancer. 92(12)

BACKGROUND The development of effective chemotherapy for central nervous system tumors is hampered by the blood-brain barrier and by limited drug diffusion in the brain tissue. BAY 59-8862 is a new taxane analog that was selected and developed for it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d42d8427705db1bfb0db49120504c6e
https://pubmed.ncbi.nlm.nih.gov/11753988

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