Future Education and Its Challenges: A Millennial’s Perspective

Autor: Marco Vitiello

Publikováno v: Cadmus, Vol 4, Iss 2, Pp 282-290 (2020)

In a rapidly changing world, school systems need to adapt themselves rapidly in order to be able to prepare their students for the upcoming challenges that are threatening the world today. If many steps have been taken by humanity towards progress,

Externí odkaz: https://doaj.org/article/10d46a56761e44beae7ee397b96a286a

Antibacterial activity of novel dual bacterial DNA type II topoisomerase inhibitors.

Autor: Noemi D'Atanasio, Alessandra Capezzone de Joannon, Laura Di Sante, Giorgina Mangano, Rosella Ombrato, Marco Vitiello, Cristina Bartella, Gabriele Magarò, Federica Prati, Claudio Milanese, Carla Vignaroli, Francesco Paolo Di Giorgio, Serena Tongiani

Publikováno v: PLoS ONE, Vol 15, Iss 2, p e0228509 (2020)

In this study, a drug discovery programme that sought to identify novel dual bacterial topoisomerase II inhibitors (NBTIs) led to the selection of six optimized compounds. In enzymatic assays, the molecules showed equivalent dual-targeting activity a

Externí odkaz: https://doaj.org/article/96e4320901204a7eb92810eea290642f

A Novel Multi-step Virtual Screening for the Identification of Human and Mouse mPGES-1 Inhibitors

Autor: Marco Vitiello, Rosella Ombrato, Guido Furlotti, Maria Alessandra Alisi, Francesca Mancini, Isabella Coletta, Nicola Cazzolla, Giorgina Mangano, Barbara Garofalo, Gaia Corso

Publikováno v: Molecular Informatics. 35:358-368

We present here the development of a novel virtual screening protocol combining Structure-based and Ligand-based drug design approaches for the identification of mouse mPGES-1 inhibitors. We used the existing1 3D structural data of the murine enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d2366f231628750eac1b522bb45803
https://doi.org/10.1002/minf.201600024

Targeting Serotonin 2A and Adrenergic α

Autor: Guido, Furlotti, Maria Alessandra, Alisi, Nicola, Cazzolla, Francesca, Ceccacci, Beatrice, Garrone, Tecla, Gasperi, Angela, La Bella, Francesca, Leonelli, Maria Antonietta, Loreto, Gabriele, Magarò, Giorgina, Mangano, Rinaldo Marini, Bettolo, Emanuela, Masini, Martina, Miceli, Luisa Maria, Migneco, Marco, Vitiello

Publikováno v: ChemMedChem. 13(15)

Glaucoma affects millions of people worldwide and causes optic nerve damage and blindness. The elevation of the intraocular pressure (IOP) is the main risk factor associated with this pathology, and decreasing IOP is the key therapeutic target of cur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ce0b61b7c86e4940e4669806e2506a24
https://pubmed.ncbi.nlm.nih.gov/29873449

Targeting Serotonin 2A and Adrenergic α1 Receptors for Ocular Antihypertensive Agents: Discovery of 3,4-Dihydropyrazino[1,2-b]indazol-1(2H)-one Derivatives

Autor: M. A. Loreto, Marco Vitiello, Beatrice Garrone, Martina Miceli, Maria Alessandra Alisi, Magaro' Gabriele, Rinaldo Marini Bettolo, Emanuela Masini, Luisa Maria Migneco, Guido Furlotti, Francesca Leonelli, Nicola Cazzolla, Giorgina Mangano, Tecla Gasperi, Francesca Ceccacci, Angela La Bella

Publikováno v: ChemMedChem
13 (2018): 1597–1607. doi:10.1002/cmdc.201800199
info:cnr-pdr/source/autori:Furlotti G. (a); Alisi M. A. (a); Cazzolla N. (a); Ceccacci F. (b,f); Garrone B. (a); Gasperi T. (d); La Bella A. (b); Leonelli F. (b,c); Loreto M. A. (b); Magarò G. (a); Mangano G. (a); Marini Bettolo R. (b); Masini E. (e); Miceli M. (d); Migneco L. M. (b); Vitiello M. (a)/titolo:Targeting Serotonin 2A and Adrenergic alfa1 Receptors for Ocular Antihypertensive Agents: Discovery of 3,4-Dihydropyrazino[1,2-b]indazol-1(2H)-one Derivatives/doi:10.1002%2Fcmdc.201800199/rivista:ChemMedChem (Print)/anno:2018/pagina_da:1597/pagina_a:1607/intervallo_pagine:1597–1607/volume:13

Glaucoma affects millions of people worldwide, causing optic nerve damage and blindness. The elevation of the intraocular pressure (IOP) is the main risk factor associated with this pathology, and nowadays, the key therapeutic target of the existing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612c3db8946e01f1e85f720922748c76
https://hdl.handle.net/11590/336581