Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Marco Vergelli"'
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
Autor:
Irena Stefanova, Roland Martin, Bernhard Hemmer, Marco Vergelli, William E. Biddison, Ronald N. Germain
Publikováno v:
Nature Immunology. 4:248-254
Functional discrimination between structurally similar self and foreign antigens is a main attribute of adaptive immunity. Here we describe two feedback mechanisms in T lymphocytes that together sharpen and amplify initial signaling differences relat
Autor:
Benedetta Mazzanti, Eleonora Rosati, Marco Vergelli, Tiziana Biagioli, A Ben Nun, Clara Ballerini, Luca Massacesi, E. Traggiai
Publikováno v:
Journal of Neuroimmunology. 121:111-119
In this study, we investigated the in vitro proliferative response of peripheral blood T lymphocytes from MS patients and controls to MBP and MOG either in the absence or in the presence of the conditioning factor IL-7. In the absence of IL-7, T-cell
Autor:
G. Pellicanò, A. Konse, Luca Massacesi, E. Traggiai, A. Parigi, Tiziana Biagioli, Benedetta Mazzanti, Clara Ballerini, Marco Vergelli
Publikováno v:
Journal of Neuroscience Research. 66:517-524
T cells reactive to self-antigens are present in the peripheral blood of patients with autoimmune diseases as well as in healthy subjects. Although T cell-response to the self-myelin antigen myelin basic protein (MBP) has been widely investigated in
Autor:
Donella Gestri, Enrico Maggi, Baldacci L, R. Taiuti, Marie-Pierre Piccinni, Luca Massacesi, Galli E, Marco Vergelli
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 70:767-772
OBJECTIVE—To evaluate the T cell receptor β chain variable region (TCRBV) gene usage ex vivo in CSF cells and peripheral blood mononuclear cells (PBMCs) collected from patients with autoimmune and inflammatory diseases of the nervous system. METHO
Publikováno v:
Annals of Neurology
Various mechanisms have been proposed for the initiation of autoimmune responses by autoreactive T‐cell clones. One of these, the molecular mimicry hypothesis, postulates that myelin‐reactive T‐cell clones are activated by foreign antigens. Unt
Autor:
G. Rapi, Luca Massacesi, Marco Vergelli, Mario Chelli, Elena Nardi, Anna Maria Papini, Luigi Amaducci, Benedetta Mazzanti, Silvia Mazzucco, Mauro Ginanneschi
Publikováno v:
Letters in Peptide Science. 6:51-59
We previously demonstrated that the lipopeptide of the myelin basic protein (MBP) immunodominant epitope in Lewis rat Palm-GpMBP(74-85) (Gp: guinea pig), which induced experimental autoimmune encephalomyelitisin vivo strongly increased the T cell pro
Autor:
Bernhard Hemmer, Marco Vergelli, Bruno Gran, Nick Ling, Paul Conlon, Clemencia Pinilla, Richard Houghten, Henry F. McFarland, Roland Martin
Publikováno v:
The Journal of Immunology. 160:3631-3636
The potential of CD4+ T cells for cross-recognition of self and foreign Ags has important implications for the understanding of thymic selection, lymphocyte survival, and the occurrence of autoimmune diseases. Here, we define the extensive flexibilit
Autor:
S.C Rojo, Hermann Beck, M. Kalbus, L. R. Tranquill, B. Hemmer, R De Mars, Henry F. McFarland, Hubert Kalbacher, Eric O. Long, Marco Vergelli, Roland Martin
Publikováno v:
Journal of Neuroimmunology. 77:195-203
In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DR alpha paired with the beta chain encoded by DRB5*0101) and DR2b (DR alpha paired with the beta chain encoded by DRB1*1501), that are coexpressed in the multiple
Autor:
Marco Vergelli, Burkhard Fleckenstein, Karl Heinz Wiesmüller, Henry F. McFarland, Günther Jung, Bernhard Hemmer, Roland Martin
Publikováno v:
Journal of Experimental Medicine. 185:1651-1660
CD4+ class II–restricted T cells specific for self antigens are thought to be involved in the pathogenesis of most human autoimmune diseases and molecular mimicry between foreign and self ligands has been implicated as a possible mechanism for thei
Autor:
Marco Vergelli, Roland Martin, T. Huang, Bernhard Hemmer, P. A. Calabresi, Henry F. McFarland
Publikováno v:
Journal of Neuroscience Research. 45:852-862
Experimental allergic encephalomyelitis (EAE), an animal model resembling multiple sclerosis (MS), is mediated by myelin antigen-specific CD4+ T cells secreting cytokines such as interferon-gamma (IFN-gamma), tumor necrosis factor-beta (TNF-beta), an