Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling

Autor: Daniela Gaglio 1, 2, Marcella Bonanomi 2, 3, Silvia Valtorta 1, 4, Rohit Bharat 23, Marilena Ripamonti 1, Federica Conte 2, 5, Giulia Fiscon 2, Nicole Righi 2, Elisabetta Napodano 1, Federico Papa 2, Isabella Raccagni 1, 6, Seth J Parker 7, 8, Ingrid Cifola 9, Tania Camboni 9, Paola Paci 2, Anna Maria Colangelo 2, Marco Vanoni 2, Christian M Metallo 7, Rosa Maria Moresco 1, Lilia Alberghina 2

Publikováno v: Cancer & Metabolism, Vol 8, Iss 1, Pp 1-15 (2020)
Cancer & metabolism 8 (2020): 22. doi:10.1186/s40170-020-00227-4
info:cnr-pdr/source/autori:Daniela Gaglio 1,2, Marcella Bonanomi 2,3, Silvia Valtorta 1,2,4, Rohit Bharat 23, Marilena Ripamonti 1,2, Federica Conte 2,5, Giulia Fiscon 2,5, Nicole Righi 2,3, Elisabetta Napodano 1,2, Federico Papa 2,5, Isabella Raccagni 1,2,6, Seth J Parker 7,8, Ingrid Cifola 9, Tania Camboni 9, Paola Paci 2,5,10, Anna Maria Colangelo 2,3, Marco Vanoni 2,3, Christian M Metallo 7,8, Rosa Maria Moresco 1,2,4, Lilia Alberghina 2,3/titolo:Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling/doi:10.1186%2Fs40170-020-00227-4/rivista:Cancer & metabolism/anno:2020/pagina_da:22/pagina_a:/intervallo_pagine:22/volume:8
Cancer & Metabolism

Abstract Background Rewiring of metabolism induced by oncogenic K-Ras in cancer cells involves both glucose and glutamine utilization sustaining enhanced, unrestricted growth. The development of effective anti-cancer treatments targeting metabolism m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950f4c1a96c7b0580200136e0d3aea0e
http://link.springer.com/article/10.1186/s40170-020-00227-4