Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Marco V. Haselager"'
Autor:
Marco V. Haselager, Rachel Thijssen, Danique Bax, Demi Both, Francien De Boer, Simon Mackay, Julie Dubois, Clemens Mellink, Arnon P. Kater, Eric Eldering
Publikováno v:
Molecular Oncology, Vol 17, Iss 6, Pp 1112-1128 (2023)
Preventing or overcoming resistance to the Bcl‐2 inhibitor venetoclax is an emerging unmet clinical need in patients with chronic lymphocytic leukaemia (CLL). The upregulation of anti‐apoptotic Bcl‐2 members through signalling pathways within t
Externí odkaz:
https://doaj.org/article/2e43009de0ac4b10a008f5313a882ab0
Autor:
Marco V. Haselager, Bianca F. van Driel, Eduard Perelaer, Dennis de Rooij, Danial Lashgari, Remco Loos, Arnon P. Kater, Perry D. Moerland, Eric Eldering
Publikováno v:
HemaSphere, Vol 7, Iss 9, p e938 (2023)
Chronic lymphocytic leukemia (CLL) cells are highly dependent on microenvironmental cells and signals. The lymph node (LN) is the critical site of in vivo CLL proliferation and development of resistance to both chemotherapy and targeted agents. We pr
Externí odkaz:
https://doaj.org/article/7bad755cafac4a3baec0ab51f9c88c15
Autor:
Marco V. Haselager, Eric Eldering
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
NF-κB-inducing kinase (NIK) is a key player in non-canonical NF-κB signaling, involved in several fundamental cellular processes, and is crucial for B cell function and development. In response to certain signals and ligands, such as CD40, BAFF and
Externí odkaz:
https://doaj.org/article/210ca4c907c14fda8e1381912dd9b2e9
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Chronic lymphocytic leukemia (CLL) cells cycle between lymphoid tissue sites where they actively proliferate, and the peripheral blood (PB) where they become quiescent. Strong evidence exists for a crucial role of B cell receptor (BCR) triggering, ei
Externí odkaz:
https://doaj.org/article/f9bc311a4d174a9abbd861c0572cbcda
Autor:
Karoline Kielbassa, Marco V. Haselager, Danique J. C. Bax, Bianca F. van Driel, Julie Dubois, Mark-David Levin, Sabina Kersting, Rebecka Svanberg, Carsten U. Niemann, Arnon P. Kater, Eric Eldering
Publikováno v:
Leukemia.
Chronic lymphocytic leukemia (CLL) cells upregulate Bcl-2 proteins within the lymph node (LN) microenvironment. Signaling via B-cell receptor, Toll-like receptors and CD40 collectively reduce sensitivity to the BCL-2 inhibitor venetoclax. Time-limite
Autor:
null Marco V. Haselager, null Rachel Thijssen, null Danique Bax, null Demi Both, null Francien De Boer, null Simon Mackay, null Julie Dubois, null Clemens Mellink, null Arnon P. Kater, null Eric Eldering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bea98a1602493861cf6f7162912b1e
https://doi.org/10.1002/1878-0261.13364/v3/response1
https://doi.org/10.1002/1878-0261.13364/v3/response1
Autor:
Marco V. Haselager, Rachel Thijssen, Danique Bax, Demi Both, Francien De Boer, Simon Mackay, Julie Dubois, Clemens Mellink, Arnon P. Kater, Eric Eldering
Publikováno v:
Molecular oncology. Elsevier
Haselager, M V, Thijssen, R, Bax, D, Both, D, de Boer, F, Mackay, S, Dubois, J, Mellink, C, Kater, A P & Eldering, E 2022, ' JAK–STAT signalling shapes the NF-κB response in CLL towards venetoclax sensitivity or resistance via Bcl-XL ', Molecular oncology . https://doi.org/10.1002/1878-0261.13364
Haselager, M V, Thijssen, R, Bax, D, Both, D, de Boer, F, Mackay, S, Dubois, J, Mellink, C, Kater, A P & Eldering, E 2022, ' JAK–STAT signalling shapes the NF-κB response in CLL towards venetoclax sensitivity or resistance via Bcl-XL ', Molecular oncology . https://doi.org/10.1002/1878-0261.13364
Preventing or overcoming resistance to the Bcl-2 inhibitor venetoclax is an emerging unmet clinical need in patients with chronic lymphocytic leukaemia (CLL). The upregulation of anti-apoptotic Bcl-2 members through signalling pathways within the tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d35d8654653f5b16a694f07088fe92
https://pure.amc.nl/en/publications/jakstat-signalling-shapes-the-nfb-response-in-cll-towards-venetoclax-sensitivity-or-resistance-via-bclxl(4a996479-0622-45fc-93e2-335ac2000c94).html
https://pure.amc.nl/en/publications/jakstat-signalling-shapes-the-nfb-response-in-cll-towards-venetoclax-sensitivity-or-resistance-via-bclxl(4a996479-0622-45fc-93e2-335ac2000c94).html