Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Marco Tutone"'
Autor:
Marco Tutone, Anna Maria Almerico
Publikováno v:
Molecules, Vol 29, Iss 5, p 969 (2024)
Science is a point of view [...]
Externí odkaz:
https://doaj.org/article/5b93cf0fed0b47f4a45e9530018da9d3
Autor:
Riccardo Perriera, Emanuele Vitale, Ivana Pibiri, Pietro Salvatore Carollo, Davide Ricci, Federica Corrao, Ignazio Fiduccia, Raffaella Melfi, Maria Grazia Zizzo, Marco Tutone, Andrea Pace, Laura Lentini
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15084 (2023)
Nonsense mutations cause several genetic diseases such as cystic fibrosis, Duchenne muscular dystrophy, β-thalassemia, and Shwachman–Diamond syndrome. These mutations induce the formation of a premature termination codon (PTC) inside the mRNA sequ
Externí odkaz:
https://doaj.org/article/5663dbfb9dbc499b869eb2cb424ba1ab
Autor:
Federica Corrao, Maria Grazia Zizzo, Marco Tutone, Raffaella Melfi, Ignazio Fiduccia, Pietro Salvatore Carollo, Aldo Di Leonardo, Gaetano Caldara, Riccardo Perriera, Andrea Pace, Beatrice Belmonte, Selene Sammataro, Ivana Pibiri, Laura Lentini
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113886- (2022)
Stop mutations cause 11% of the genetic diseases, due to the introduction of a premature termination codon (PTC) in the mRNA, followed by the production of a truncated protein. A promising therapeutic approach is the suppression therapy by Translatio
Externí odkaz:
https://doaj.org/article/96d8fcb1f02b48969527e8b5b31f7c6a
Autor:
Giulia Culletta, Marco Tutone, Roberta Ettari, Ugo Perricone, Carla Di Chio, Anna Maria Almerico, Maria Zappalà
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10504 (2023)
Immunoproteasome inhibition is a promising strategy for the treatment of hematological malignancies, autoimmune diseases, and inflammatory diseases. The design of non-covalent inhibitors of the immunoproteasome β1i/β5i catalytic subunits could be a
Externí odkaz:
https://doaj.org/article/f1bfabbe98874a53bfbba4a8d4b73596
Autor:
Pietro Salvatore Carollo, Marco Tutone, Giulia Culletta, Ignazio Fiduccia, Federica Corrao, Ivana Pibiri, Aldo Di Leonardo, Maria Grazia Zizzo, Raffaella Melfi, Andrea Pace, Anna Maria Almerico, Laura Lentini
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9609 (2023)
Cystic Fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, coding for the CFTR chloride channel. About 10% of the CFTR gene mutations are “stop” mutations that generate a premature termination codon (PTC)
Externí odkaz:
https://doaj.org/article/1d050d4f5ab14431b3009790e93f1566
Autor:
M. Akiful Haque, Akash Marathakam, Ritesh Rana, Samar J Almehmadi, Vishal B. Tambe, Manoj S. Charde, Fahadul Islam, Falak A. Siddiqui, Giulia Culletta, Anna Maria Almerico, Marco Tutone, Sharuk L. Khan
Publikováno v:
Molecules, Vol 28, Iss 2, p 501 (2023)
The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors. These compounds were filtered by using ADMET, drug-likeness characteristics calcul
Externí odkaz:
https://doaj.org/article/6190939685294e0bb355a7bcdf6a987b
Autor:
Alessandro Attanzio, Ignazio Restivo, Marco Tutone, Luisa Tesoriere, Mario Allegra, Maria A. Livrea
Publikováno v:
Antioxidants, Vol 11, Iss 12, p 2364 (2022)
Phytochemicals from plant foods are considered essential to human health. Known for their role in the adaptation of plants to their environment, these compounds can induce adaptive responses in cells, many of which are directed at maintaining the red
Externí odkaz:
https://doaj.org/article/bb345ff7be414ea8a43d289ac686195d
Autor:
Mario Allegra, Marco Tutone, Luisa Tesoriere, Alessandro Attanzio, Giulia Culletta, Anna Maria Almerico
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Indicaxanthin, a betaxanthin belonging to the betalain class of compounds, has been recently demonstrated to exert significant antiproliferative effects inducing apoptosis of human melanoma cells through the inhibition of NF-κB as the pr
Externí odkaz:
https://doaj.org/article/680010cce48644e7b17fc7c249d4b9f3
Autor:
Abhay Tiwari, Garima Singh, Gourav Choudhir, Mohit Motiwale, Nidhi Joshi, Vasudha Sharma, Rupesh K. Srivastava, Satyawati Sharma, Marco Tutone, Pradeep Kumar Singour
Publikováno v:
Molecules, Vol 27, Iss 17, p 5620 (2022)
Vitamin D’s role in combating the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the virus causing COVID-19, has been established in unveiling viable inhibitors of COVID-19. The current study investigated the role of pre and pro-vita
Externí odkaz:
https://doaj.org/article/b1fa13e0255848cb8f394ad24e5daba4
Autor:
Gianfranco Fontana, Natale Badalamenti, Maurizio Bruno, Davide Castiglione, Monica Notarbartolo, Paola Poma, Alberto Spinella, Marco Tutone, Manuela Labbozzetta
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6594 (2022)
Oleanolic acid (OA) and Lupeol (LU) belong to the class of natural triterpenes and are endowed with a wide range of biological activities, including cytotoxicity toward several cancer cell lines. In this context, we investigated a set of compounds ob
Externí odkaz:
https://doaj.org/article/0a399c363b3f4d5990afd68bd6b59637