Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marco T. Nuñez"'
Autor:
Marco T. Nuñez, Pedro Chana-Cuevas
Publikováno v:
Pharmaceuticals, Vol 11, Iss 4, p 109 (2018)
Iron chelation has been introduced as a new therapeutic concept for the treatment of neurodegenerative diseases with features of iron overload. At difference with iron chelators used in systemic diseases, effective chelators for the treatment of neur
Externí odkaz:
https://doaj.org/article/5b96f86952234ed7975343b68d67715a
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1791-C1806
Iron absorption is a complex and highly controlled process where DMT1 transports nonheme iron through the brush-border membrane of enterocytes to the cytoplasm but does not transport alkaline-earth metals such as calcium. However, it has been propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d260387e3472e50e66f2647f39387cec
https://doi.org/10.1152/ajpcell.00411.2022
https://doi.org/10.1152/ajpcell.00411.2022
Autor:
Marisol, Gómez, Margarita E, Aliaga, Verónica, Arancibia, Alexis, Moya, Camilo, Segura, Marco T, Nuñez, Pabla, Aguirre, Edgar, Nagles, Olimpo, García-Beltrán
Publikováno v:
RSC advances. 8(55)
A new probe (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::701e368e5755c378c958884e1c87145d
https://pubmed.ncbi.nlm.nih.gov/35548216
https://pubmed.ncbi.nlm.nih.gov/35548216
Publikováno v:
Antioxidants, Vol 13, Iss 2, p 196 (2024)
Ferroptosis is an iron-dependent cell death pathway that involves the depletion of intracellular glutathione (GSH) levels and iron-mediated lipid peroxidation. Ferroptosis is experimentally caused by the inhibition of the cystine/glutamate antiporter
Externí odkaz:
https://doaj.org/article/adeba5054ea6414aa2cb9afdc4a22958
Publikováno v:
Free Radical Biology and Medicine. 120:S146
Physiological levels of ROS are important for several processes in the nervous system, ranging from neuronal precursors proliferation, to axonal guidance and neurotransmission. ROS also support neurite outgrowth and axonal specification, but the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a0e40c1e022138b97e996794823a6ce
https://doi.org/10.1016/j.freeradbiomed.2018.04.480
https://doi.org/10.1016/j.freeradbiomed.2018.04.480
Autor:
Silvia Gleitze, Omar A. Ramírez, Ignacio Vega-Vásquez, Jing Yan, Pedro Lobos, Hilmar Bading, Marco T. Núñez, Andrea Paula-Lima, Cecilia Hidalgo
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 705 (2023)
Ferroptosis, a newly described form of regulated cell death, is characterized by the iron-dependent accumulation of lipid peroxides, glutathione depletion, mitochondrial alterations, and enhanced lipoxygenase activity. Inhibition of glutathione perox
Externí odkaz:
https://doaj.org/article/7e44a1aca8de4abd84363887a9a07e2c
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 214 (2023)
Protein aggregation, mitochondrial dysfunction, iron dyshomeostasis, increased oxidative damage and inflammation are pathognomonic features of Parkinson’s disease (PD) and other neurodegenerative disorders characterized by abnormal iron accumulatio
Externí odkaz:
https://doaj.org/article/1d7d30cd1951413a87391120ce20c221
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1807 (2022)
Selective regional iron accumulation is a hallmark of several neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. The underlying mechanisms of neuronal iron dyshomeostasis have been studied, mainly in a gene-by-gene
Externí odkaz:
https://doaj.org/article/88154fda5feb418081958e0ba9cdc27b
Autor:
Olimpo García-Beltrán, Bruce K. Cassels, Claudio Pérez, Natalia Mena, Marco T. Núñez, Natalia P. Martínez, Paulina Pavez, Margarita E. Aliaga
Publikováno v:
Sensors, Vol 14, Iss 1, Pp 1358-1371 (2014)
Two new coumarin-based “turn-off” fluorescent probes, (E)-3-((3,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS1) and (E)-3-((2,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS2), were synthesized and their detection of c
Externí odkaz:
https://doaj.org/article/16965f69964a46bdb99809358921d1bf
Publikováno v:
Parkinson's Disease, Vol 2016 (2016)
Mitochondrial dysfunction, iron accumulation, and oxidative damage are conditions often found in damaged brain areas of Parkinson’s disease. We propose that a causal link exists between these three events. Mitochondrial dysfunction results not only
Externí odkaz:
https://doaj.org/article/496d35d3cc13478194e66efdbdd3c20e