Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Marco T Nuñez"'
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218123 (2019)
Iron is essential for the normal development of cellular processes. This metal has a high redox potential that can damage cells and its overload or deficiency is related to several diseases, therefore it is crucial for its absorption to be highly reg
Externí odkaz:
https://doaj.org/article/65bbb545ad4a4745a0148caeee954b75
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169601 (2017)
Iron is a trace metal, key for the development of living organisms. Its absorption process is complex and highly regulated at the transcriptional, translational and systemic levels. Recently, the internalization of the DMT1 transporter has been propo
Externí odkaz:
https://doaj.org/article/5f56e1ce59a945f7b2259e720d050167
Publikováno v:
Biological Research, Vol 33, Iss 2, Pp 133-142 (2000)
Cells tightly regulate iron levels through the activity of iron regulatory proteins (IRPs) that bind to RNA motifs called iron responsive elements (IREs). When cells become iron-depleted, IRPs bind to IREs present in the mRNAs of ferritin and the tra
Externí odkaz:
https://doaj.org/article/9392a7d8bc2a468cb69c02d5aae7e305
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1791-C1806
Iron absorption is a complex and highly controlled process where DMT1 transports nonheme iron through the brush-border membrane of enterocytes to the cytoplasm but does not transport alkaline-earth metals such as calcium. However, it has been propose
Autor:
Marisol, Gómez, Margarita E, Aliaga, Verónica, Arancibia, Alexis, Moya, Camilo, Segura, Marco T, Nuñez, Pabla, Aguirre, Edgar, Nagles, Olimpo, García-Beltrán
Publikováno v:
RSC advances. 8(55)
A new probe (
Publikováno v:
Free Radical Biology and Medicine. 120:S146
Physiological levels of ROS are important for several processes in the nervous system, ranging from neuronal precursors proliferation, to axonal guidance and neurotransmission. ROS also support neurite outgrowth and axonal specification, but the mech
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 5, Pp 1003-1004 (2022)
Externí odkaz:
https://doaj.org/article/64556740e85a457bbd95b007af46c14e
Autor:
Marco T Nunez, Pedro Chana-Cuevas
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 11, Pp 1905-1906 (2019)
Externí odkaz:
https://doaj.org/article/21364d6f50c048d78519005565fe7332
Autor:
Olimpo García-Beltrán, Natalia P Mena, Pabla Aguirre, Germán Barriga-González, Antonio Galdámez, Edgar Nagles, Tatiana Adasme, Cecilia Hidalgo, Marco T Núñez
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189043 (2017)
Iron accumulation, oxidative stress and calcium signaling dysregulation are common pathognomonic signs of several neurodegenerative diseases, including Parkinson´s and Alzheimer's diseases, Friedreich ataxia and Huntington's disease. Given their the
Externí odkaz:
https://doaj.org/article/07513b7a3cd840afac3e9920a4d04929
Autor:
Pabla Aguirre, Natalia P Mena, Carlos M Carrasco, Yorka Muñoz, Patricio Pérez-Henríquez, Rodrigo A Morales, Bruce K Cassels, Carolina Méndez-Gálvez, Olimpo García-Beltrán, Christian González-Billault, Marco T Núñez
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144848 (2015)
Neuronal death in Parkinson's disease (PD) is often preceded by axodendritic tree retraction and loss of neuronal functionality. The presence of non-functional but live neurons opens therapeutic possibilities to recover functionality before clinical
Externí odkaz:
https://doaj.org/article/07e3dcd9b356406682ba92db1457d413