Výsledky vyhledávání - "Marco Túlio R Gomes"

Akademický článek

Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection.

Autor: Daiane M Cerqueira, Marco Túlio R Gomes, Alexandre L N Silva, Marcella Rungue, Natan R G Assis, Erika S Guimarães, Suellen B Morais, Petr Broz, Dario S Zamboni, Sergio C Oliveira

Publikováno v: PLoS Pathogens, Vol 14, Iss 12, p e1007519 (2018)

Innate immune response against Brucella abortus involves activation of Toll-like receptors (TLRs) and NOD-like receptors (NLRs). Among the NLRs involved in the recognition of B. abortus are NLRP3 and AIM2. Here, we demonstrate that B. abortus trigger

Externí odkaz: https://doaj.org/article/a8310491074f45678e18d0d2ff7ae6b3

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Akademický článek

Canonical and Non-canonical Inflammasome Activation by Outer Membrane Vesicles Derived From Bordetella pertussis

Autor: Maia L. Elizagaray, Marco Túlio R. Gomes, Erika S. Guimaraes, Martín Rumbo, Daniela F. Hozbor, Sergio C. Oliveira, Griselda Moreno

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Outer Membrane Vesicles (OMVs) derived from different Gram-negative bacteria have been proposed as an attractive vaccine platform because of their own immunogenic adjuvant properties. Pertussis or whooping cough is a highly contagious vaccine-prevent

Externí odkaz: https://doaj.org/article/9fd35311813a450e98b99971630b131d

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Akademický článek

Lack of Interleukin-6 Affects IFN-γ and TNF-α Production and Early In Vivo Control of Brucella abortus Infection

Autor: Erika S. Guimarães, Jéssica M. Martins, Marco Túlio R. Gomes, Daiane M. Cerqueira, Sergio C. Oliveira

Publikováno v: Pathogens, Vol 9, Iss 12, p 1040 (2020)

Interleukin-6 (IL-6) is a pleiotropic cytokine promptly produced in response to infections, which contributes to host defense through the stimulation of acute phase immune responses. Brucella abortus is an intracellular bacterium that causes chronic

Externí odkaz: https://doaj.org/article/ce046aa5efdf4a918b62cf78e579e53c

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Akademický článek

miR-181a-5p Regulates TNF-α and miR-21a-5p Influences Gualynate-Binding Protein 5 and IL-10 Expression in Macrophages Affecting Host Control of Brucella abortus Infection

Autor: Patrícia P. Corsetti, Leonardo A. de Almeida, André Nicolau Aquime Gonçalves, Marco Túlio R. Gomes, Erika S. Guimarães, João T. Marques, Sergio C. Oliveira

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Brucella abortus is a Gram-negative intracellular bacterium that causes a worldwide zoonosis termed brucellosis, which is characterized as a debilitating infection with serious clinical manifestations leading to severe complications. In spite of grea

Externí odkaz: https://doaj.org/article/f7bd1195ddbd47e8a13ca50510c998f1

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The endoplasmic reticulum stress sensor IRE1α modulates macrophage metabolic function during Brucella abortus infection

Autor: Erika S. Guimarães, Marco Túlio R. Gomes, Rodrigo C. O. Sanches, Kely Catarine Matteucci, Fábio V. Marinho, Sergio C. Oliveira

Publikováno v: Frontiers in Immunology. 13

Endoplasmic reticulum (ER) stress plays a major role in several inflammatory disorders. ER stress induces the unfolded protein response (UPR), a conserved response broadly associated with innate immunity and cell metabolic function in various scenari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20aa1aecb84e4c1f103f47c026627a47
https://doi.org/10.3389/fimmu.2022.1063221

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Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection

Autor: Marco Túlio R. Gomes, Lunna T S Diniz, Sergio C. Oliveira, Júlia S. Fahel, Ana Paula Junqueira-Kipnis, Danilo Pires Resende, Ana Carolina V. S. C. de Araujo, Fábio V. Marinho

Publikováno v: Journal of Leukocyte Biology. 108:1279-1291

Guanylate binding proteins (GBPs) are important effector molecules of autonomous response induced by proinflammatory stimuli, mainly IFNs. The murine GBPs clustered in chromosome 3 (GBPchr3) contains the majority of human homologous GBPs. Despite int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df020feb9e38666e67351342a3e57a3
https://doi.org/10.1002/jlb.4ma0620-526rr

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Brucella abortusnitric oxide metabolite regulates inflammasome activation and IL‐1β secretion in murine macrophages

Autor: Mariza Gabriela Faleiro de Moura Lodi Cruz, Sergio C. Oliveira, Priscila C. Campos, Marco Túlio R. Gomes, Erika S. Guimarães, Fábio V. Marinho

Publikováno v: Eur J Immunol

NLRP3 inflammasome is a protein complex crucial to caspase-1 activation and IL-1β and IL-18 maturation. This receptor participates in innate immune responses to different pathogens, including the bacteria of genus Brucella. Our group recently demons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e91ffe236d60815de16b773f17c3d0
https://doi.org/10.1002/eji.201848016

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Guanylate-binding proteins at the crossroad of noncanonical inflammasome activation during bacterial infections

Autor: Daiane M. Cerqueira, Sergio C. Oliveira, Marco Túlio R. Gomes, Erika S. Guimarães, Priscila C. Campos

Publikováno v: J Leukoc Biol

The immune system is armed with a broad range of receptors to detect and initiate the elimination of bacterial pathogens. Inflammasomes are molecular platforms that sense a diverse range of microbial insults to develop appropriate host response. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed8a3964b2b171c60ee8cd4be6d9211
https://doi.org/10.1002/jlb.4mr0119-013r

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Galectin-3 regulates proinflammatory cytokine function and favors Brucella abortus chronic replication in macrophages and mice

Autor: Priscila C. Campos, Marco Túlio R. Gomes, Daiane M. Cerqueira, Sergio C. Oliveira, Fernanda L Tana, Erika S. Guimarães, Fábio V. Marinho

Publikováno v: Cell Microbiol

In this study, we provide evidence that galectin-3 (Gal-3) plays an important role in Brucella abortus infection. Our results showed increased Gal-3 expression and secretion in B. abortus infected macrophages and mice. Additionally, our findings indi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae9aafd1208b10c312bc217a2f6848a
https://europepmc.org/articles/PMC8635083/

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STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection

Autor: Fábio V. Marinho, Marco Túlio R. Gomes, Eric R.G.R. Aguiar, Erika S. Guimarães, Sergio C. Oliveira, Glen N. Barber, Pedro M. Moraes-Vieira, José C. Alves-Filho, Isabella Barony Macedo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Pathogens, Vol 17, Iss 5, p e1009597 (2021)
PLoS Pathogens

Macrophages metabolic reprogramming in response to microbial insults is a major determinant of pathogen growth or containment. Here, we reveal a distinct mechanism by which stimulator of interferon genes (STING), a cytosolic sensor that regulates inn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2fd8ab18523b3a3a2e20dc5d3ea79f

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