Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Marco Scocchi"'
Autor:
Alessandro Tossi, Marco Gerdol, Andrea Caporale, Sabrina Pacor, Mario Mardirossian, Marco Scocchi, Michael D. Prickett, Giorgio Manzini, Renato Gennaro
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
Cathelicidins are a ubiquitous family of host defence antimicrobial peptides in vertebrate animals. Unlike other antimicrobial peptide families, it is defined by a large and relatively well conserved proregion rather than by the mature bioactive pept
Externí odkaz:
https://doaj.org/article/26a1fe3bc21344bea367c685ee44b922
Autor:
Barbara Biondi, Luigi de Pascale, Mario Mardirossian, Adriana Di Stasi, Matteo Favaro, Marco Scocchi, Cristina Peggion
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Cathelicidins, a family of host defence peptides in vertebrates, play an important role in the innate immune response, exhibiting antimicrobial activity against many bacteria, as well as viruses and fungi. This work describes the design and
Externí odkaz:
https://doaj.org/article/d35cfc98c9b94ea492a6cc8d77a86989
Autor:
Kai Hilpert, Jurnorain Gani, Christoph Rumancev, Nathan Simpson, Paula Matilde Lopez-Perez, Vasil M. Garamus, Andreas Robert von Gundlach, Petar Markov, Marco Scocchi, Ralf Mikut, Axel Rosenhahn
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Antimicrobial peptides (AMPs) are a promising class of compounds being developed against multi-drug resistant bacteria. Hybridization has been reported to increase antimicrobial activity. Here, two proline-rich peptides (consP1: VRKPPYLPRPRPRPL-CONH2
Externí odkaz:
https://doaj.org/article/3eea9ed054df43e8ab7a3bde63e39013
Autor:
Margherita Degasperi, Riccardo Sgarra, Mario Mardirossian, Sabrina Pacor, Massimo Maschio, Marco Scocchi
Publikováno v:
Antibiotics, Vol 11, Iss 3, p 319 (2022)
As bioactive small proteins with antimicrobial and immunomodulatory activities that are naturally produced by all living organisms, antimicrobial peptides (AMPs) have a marked potential as next-generation antibiotics. However, their development as an
Externí odkaz:
https://doaj.org/article/d6788e37b83b4ec2b7078d41697ab7b3
Autor:
Mario Mardirossian, Marina Rubini, Mauro F. A. Adamo, Marco Scocchi, Michele Saviano, Alessandro Tossi, Renato Gennaro, Andrea Caporale
Publikováno v:
Molecules, Vol 26, Iss 23, p 7401 (2021)
The 3D structure and surface characteristics of proteins and peptides are crucial for interactions with receptors or ligands and can be modified to some extent to modulate their biological roles and pharmacological activities. The introduction of hal
Externí odkaz:
https://doaj.org/article/dd85456c1f53459c90ce063c6e773a2e
Autor:
Federica Armas, Sabrina Pacor, Elena Ferrari, Filomena Guida, Thelma A Pertinhez, Antonello A Romani, Marco Scocchi, Monica Benincasa
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212447 (2019)
The increasing emergence of multidrug-resistant microorganisms represents one of the greatest challenges in the clinical management of infectious diseases, and requires the development of novel antimicrobial agents. To this aim, we de novo designed a
Externí odkaz:
https://doaj.org/article/ad9810754b1e4aa49ee7b220c272a36d
Autor:
Margherita Degasperi, Chiara Agostinis, Mario Mardirossian, Massimo Maschio, Andrea Taddio, Roberta Bulla, Marco Scocchi
Publikováno v:
Microorganisms, Vol 8, Iss 9, p 1407 (2020)
Most Cystic Fibrosis (CF) patients succumb to airway inflammation and pulmonary infections due to Pseudomonas aeruginosa. D-BMAP18, a membrane-permeabilizing antimicrobial peptide composed of D-amino acids, was evaluated as a possible antibacterial a
Externí odkaz:
https://doaj.org/article/53f32998387f42b68c48010daa100fc3
Autor:
Mario Mardirossian, Arianna Pompilio, Margherita Degasperi, Giulia Runti, Sabrina Pacor, Giovanni Di Bonaventura, Marco Scocchi
Publikováno v:
Frontiers in Chemistry, Vol 5 (2017)
The spread of antibiotic resistant-pathogens is driving the search for new antimicrobial compounds. Pulmonary infections experienced by cystic fibrosis (CF) patients are a dramatic example of this health-care emergency. Antimicrobial peptides could a
Externí odkaz:
https://doaj.org/article/9f531d38b5b448dabf62dadf2a38c508
Autor:
Monica Benincasa, Quentin Barrière, Giulia Runti, Olivier Pierre, Mick Bourge, Marco Scocchi, Peter Mergaert
Publikováno v:
Bio-Protocol, Vol 6, Iss 23 (2016)
Antimicrobial peptides (AMPs) can target the bacterial envelope or alternatively have intracellular targets. The latter requires uptake of the peptide by the bacterial cells. The bacterial internalization of an AMP can be evaluated by a fluorescence-
Externí odkaz:
https://doaj.org/article/82ea1057e2f44eee8510f2dfed2ca9c9
Autor:
Victoria S Paulsen, Hans-Matti Blencke, Monica Benincasa, Tor Haug, Jacobus J Eksteen, Olaf B Styrvold, Marco Scocchi, Klara Stensvåg
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53326 (2013)
Arasin 1 is a 37 amino acid long proline-rich antimicrobial peptide isolated from the spider crab, Hyas araneus. In this work the active region of arasin 1 was identified through structure-activity studies using different peptide fragments derived fr
Externí odkaz:
https://doaj.org/article/1aefac9d6c7b436f92c8ee16251445de