Výsledky vyhledávání - "Marco S.L. Alves"

Avaliação ecocardiográfica na diabetes mellitus tipo 1

Autor: Simone Van der Sander Lee, Jefferson Luiz Brum Marques, Roberto Léo da Silva, Sandra Cossul, Thaís Rossoni Weber, Marco S.L. Alves

Publikováno v: Revista Portuguesa de Cardiologia, Vol 40, Iss 10, Pp 757-765 (2021)

Resumo: Fundamento: Diabetes mellitus tipo 1 (DM1) é uma doença crônica com pico de incidência na adolescência, com grande impacto na morbimortalidade, principalmente cardiovascular. A cardiomiopatia diabética caracteriza‐se por lesões estru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fd504cea450f2c7739c998bb27bc9f
https://doi.org/10.1016/j.repc.2020.11.012

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Echocardiographic evaluation in type 1 diabetes mellitus

Autor: Roberto Léo da Silva, Marco S.L. Alves, Jefferson Luiz Brum Marques, Sandra Cossul, Thaís Rossoni Weber, Simone Van der Sander Lee

Publikováno v: Revista portuguesa de cardiologia. 40(10)

Introduction Type 1 diabetes (T1D) is a chronic disease with peak incidence in adolescence; it has a major impact on morbidity and mortality, especially cardiovascular. Diabetic cardiomyopathy is characterized by structural and functional lesions in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3146404db172109a0b29914da965c4
https://pubmed.ncbi.nlm.nih.gov/34857115

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Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice

Autor: Robert D. Gaffin, Beata M. Wolska, Jillian N. Simon, Eric M. Montminy, R. John Solaro, David F. Wieczorek, Chad M. Warren, Marco S.L. Alves

Publikováno v: Cardiovascular Research. 113:915-925

Background Dilated cardiomoypathies (DCM) are a heterogeneous group of inherited and acquired diseases characterized by decreased contractility and enlargement of cardiac chambers and a major cause of morbidity and mortality. Mice with Glu54Lys mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506201a9ac2c09bc83710c3c176e7243
https://doi.org/10.1093/cvr/cvx068

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Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes

Autor: Beata M. Wolska, Marco S.L. Alves, Robert D. Gaffin

Publikováno v: Journal of Molecular and Cellular Cardiology. 48:834-842

Cardiomyopathies are a heterogeneous group of diseases of the myocardium associated with mechanical and/or electrical dysfunction that frequently show inappropriate ventricular hypertrophy or dilation. Current data suggest that numerous mutations in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdaf2bec25ef9db4aaef47df0c3d6c7
https://doi.org/10.1016/j.yjmcc.2010.01.003

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Síndrome da ativação do macrófago em paciente com artrite idiopática juvenil poliarticular

Autor: Eduardo Doubrawa, Acir Rachid, Francisco Luiz Gomide Mafra Magalhães, Marco S.L. Alves, Marister Malvezzi, M.M. Oliveira, Nelson Neto, Salun Coelho Aragão

Publikováno v: Revista Brasileira de Reumatologia. 44:383-389

A linfohistiocitose hemofagocitica caracteriza-se por ativacao e proliferacao excessiva de linfocitos e macrofagos. Quando associada a artrite idiopatica juvenil e tambem conhecida por "sindrome de ativacao do macrofago", sendo uma complicacao potenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf3899b1f64c8c53339b2d6e368ab4ce
https://doi.org/10.1590/s0482-50042004000500013

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Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins

Autor: Aaron C. Hinken, Chad M. Warren, R. John Solaro, Fernando Augusto Lavezzo Dias, David F. Wieczorek, Megan S. Utter, Brandon J. Biesiadecki, Eric M. Montminy, Sakthivel Sadayappan, Beata M. Wolska, Jillian N. Simon, Robert D. Gaffin, Marco S.L. Alves, rd Robert T. Davis, Jeffrey Robbins

Publikováno v: Circulation. Cardiovascular genetics. 7(2)

Background— Hypertrophic cardiomyopathy (HCM) is a common genetic disorder caused mainly by mutations in sarcomeric proteins and is characterized by maladaptive myocardial hypertrophy, diastolic heart failure, increased myofilament Ca 2+ sensitivit

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https://pubmed.ncbi.nlm.nih.gov/24585742

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Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein

Autor: Lynley S. Heinrich, Marco S.L. Alves, Fernando Augusto Lavezzo Dias, Beata M. Wolska, David F. Wieczorek, Shamim A. K. Chowdhury, James R. Peña, Paul H. Goldspink, Robert D. Gaffin, Evangelia G. Kranias

Publikováno v: Journal of molecular and cellular cardiology. 51(5)

We have recently shown that a temporary increase in sarcoplasmic reticulum (SR) cycling via adenovirus-mediated overexpression of sarcoplasmic reticulum ATPase (SERCA2) transiently improves relaxation and delays hypertrophic remodeling in a familial

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https://pubmed.ncbi.nlm.nih.gov/21840315

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Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform

Autor: Andrew B. Herr, Ilona Bodi, Ganapathy Jagatheesan, Dipak K. Dube, R. John Solaro, Arnold M. Schwartz, Marco S.L. Alves, Beata M. Wolska, Natalia Petrashevskaya, Sudarsan Rajan, Roger Hullin, Chehade N. Karam, Stephen B. Liggett, Christian F. Bulcao, David F. Wieczorek, Greg P. Boivin, Shahab A. Akhter, Karen M. D'Souza

Publikováno v: Circulation, vol. 121, no. 3, pp. 410-418

Background— Tropomyosin (TM), an essential actin-binding protein, is central to the control of calcium-regulated striated muscle contraction. Although TPM1α (also called α-TM) is the predominant TM isoform in human hearts, the precise TM isoform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13888fddce78325afffc51846fc704f6
https://pubmed.ncbi.nlm.nih.gov/20100986

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Tropomyosin Pseudo-Phosphorylation and Muscle Kinetics

Autor: Corrado Poggesi, Beata M. Wolska, Chiara Tesi, R. John Solaro, Beatrice Scellini, Marco S.L. Alves, Brandon J. Biesiadecki, David F. Wieczorek, Ganapathy Jagatheesan, Jonathan P. Davis, Bin Liu

Publikováno v: Biophysical Journal. (3):350a

Tropomyosin contains a phosphorylation site at Ser-283 located within the head-to-tail overlap region that regulates muscle contraction. Previously we demonstrated that recombinant wild-type (Tm-WT) and pseudo-phosphorylated (Tm-S283D) alpha tropomyo

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