Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marco Robello"'
Autor:
Elisabetta Barresi, Marco Robello, Emma Baglini, Valeria Poggetti, Monica Viviano, Silvia Salerno, Federico Da Settimo, Sabrina Taliani
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 997 (2023)
In recent years, indolylglyoxylamide-based derivatives have received much attention due to their application in drug design and discovery, leading to the development of a wide array of compounds that have shown a variety of pharmacological activities
Externí odkaz:
https://doaj.org/article/3d5648265e164b6a94a4793759d4bbf5
Autor:
Marco Robello, Hongchao Zheng, Mrinmoy Saha, Kara M. George Rosenker, Subrata Debnath, Jay Prakash Kumar, Harichandra D. Tagad, Sharlyn J. Mazur, Ettore Appella, Daniel H. Appella
Publikováno v:
European journal of medicinal chemistry. 243
The wild-type p53 induced phosphatase 1 (Wip1), a member of the serine/threonine-specific PP2C family, is overexpressed in numerous human cancers. Wip1 dephosphorylates p53 as well as several kinases (such as p38 MAPK, ATM, Chk1, and Chk2) in the DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60af2fe47f5d166bd42937846431f61
https://pubmed.ncbi.nlm.nih.gov/36179402
https://pubmed.ncbi.nlm.nih.gov/36179402
Autor:
Marco Robello, Silvia Salerno, Elisabetta Barresi, Paola Orlandi, Francesca Vaglini, Marta Banchi, Francesca Simorini, Emma Baglini, Valeria Poggetti, Sabrina Taliani, Federico Da Settimo, Guido Bocci
Publikováno v:
SSRN Electronic Journal.
A series of novel 3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazine (BIT) derivatives were designed and synthesized. In vitro antiproliferative activity was detected toward two human colorectal adenocarcinoma cell lines (CaCo-2 and HT-29) and one hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5b6141f579e65dd742855ea0488a7c
https://doi.org/10.2139/ssrn.4115546
https://doi.org/10.2139/ssrn.4115546
Autor:
Anna Maria Marini, Marco Robello, Federico Da Settimo, Emma Baglini, Sabrina Taliani, Silvia Salerno, Elisabetta Barresi
DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the topological state of DNA and, in eukaryotic organisms, Topos can be classified into two structurally and functionally different main classes: TopoI and TopoII. Both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab40661ec0d68dc894cc49fef6cac8be
http://hdl.handle.net/11568/1062031
http://hdl.handle.net/11568/1062031
Autor:
Elisabetta Barresi, Sabrina Taliani, Emma Baglini, Marco Robello, Federico Da Settimo, Silvia Salerno
Publikováno v:
Journal of Medicinal Chemistry
Over the years, researchers in drug discovery have taken advantage of the use of privileged structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many natural products, and it has been widely exploited by medicinal ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729fb78c242492d094dd541d0f49f5d8
http://hdl.handle.net/11568/1104203
http://hdl.handle.net/11568/1104203
Autor:
Federico Da Settimo, Sabrina Taliani, Silvia Salerno, Claudia Martini, Marco Robello, Eleonora Da Pozzo, Emma Baglini, Elisabetta Barresi, Barbara Costa
Publikováno v:
European journal of medicinal chemistry. 209
The Translocator Protein 18 kDa (TSPO) has been discovered in 1977 as an alternative binding site for the benzodiazepine diazepam. It is an evolutionary well-conserved and tryptophan-rich 169-amino acids protein with five alpha helical transmembrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e45f80999ee6a5efad37cee5c250155
https://pubmed.ncbi.nlm.nih.gov/33081988
https://pubmed.ncbi.nlm.nih.gov/33081988
Autor:
Marco Robello, Michael T. Scerba, Mrinmoy Saha, Caitlin A. Buchholz, Stewart R. Durell, Daniel H. Appella, Evan H. Pasternak, Herman Nikolayevskiy, Tracy L. Hartman, Robert W. Buckheit
Publikováno v:
Eur J Med Chem
Mercaptobenzamide thioesters and thioethers are chemically simple HIV-1 maturation inhibitors with a unique mechanism of action, low toxicity, and a high barrier to viral resistance. A structure-activity relationship (SAR) profile based on 39 mercapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a17aa3c6c50bf00c6a0333bb05d50b
https://pubmed.ncbi.nlm.nih.gov/31252286
https://pubmed.ncbi.nlm.nih.gov/31252286
Autor:
Mariafrancesca Hyeraci, Sabrina Taliani, Federico Da Settimo, Anna Maria Marini, Aída Nelly García-Argáez, Silvia Salerno, Ettore Novellino, Lisa Dalla Via, Marco Robello, Ciro Milite, Valeria La Pietra, Francesca Simorini, Elisabetta Barresi, Luciana Marinelli
New benzothiopyranoindoles (5a-l) and pyridothiopyranoindoles (5m-t), featuring different combinations of substituents (H, Cl, OCH3) at R2-R4 positions and protonatable R1-dialkylaminoalkyl chains, were synthesized and biologically assayed on three h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd5a35c0df15c7b59e9f2b5efa8ce14
http://hdl.handle.net/11568/987472
http://hdl.handle.net/11568/987472
Autor:
Federico Da Settimo, Simona Daniele, Sabrina Taliani, Luca Menichetti, Piero Salvadori, Silvia Pardini, Chiara Giacomelli, Debora Petroni, Claudia Martini, Maria Letizia Trincavelli, Marco Robello, Silvia Burchielli, Elisabetta Barresi, Antonietta Bartoli
Publikováno v:
Nuclear Medicine and Biology. 43:309-317
Introduction A 2B adenosine receptors (ARs) are commonly defined as "danger" sensors because they are triggered during cell injury when the endogenous molecule, adenosine, increases rapidly. These receptors, together with the other receptor subtypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0454dd5a0f4465edc6af4123807f284f
https://doi.org/10.1016/j.nucmedbio.2016.02.005
https://doi.org/10.1016/j.nucmedbio.2016.02.005
Autor:
Elisabetta, Barresi, Chiara, Giacomelli, Simona, Daniele, Ilaria, Tonazzini, Marco, Robello, Silvia, Salerno, Ilaria, Piano, Barbara, Cosimelli, Giovanni, Greco, Federico, Da Settimo, Claudia, Martini, Maria Letizia, Trincavelli, Sabrina, Taliani
Publikováno v:
Bioorganicmedicinal chemistry. 26(22)
The expression levels and the subcellular localization of adenosine receptors (ARs) are affected in several pathological conditions as a consequence of changes in adenosine release and metabolism. In this respect, labelled probes able to monitor the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::adf727dd00e6baba93f8e9b65c71ec38
https://pubmed.ncbi.nlm.nih.gov/30415894
https://pubmed.ncbi.nlm.nih.gov/30415894