Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Marco Preussner"'
Autor:
Miriam Bertazzon, Almudena Hurtado-Pico, Carlos Plaza-Sirvent, Marc Schuster, Marco Preußner, Benno Kuropka, Fan Liu, Andor Zenon Amandus Kirsten, Xiao Jakob Schmitt, Benjamin König, Miguel Álvaro-Benito, Esam T. Abualrous, Gesa I. Albert, Stefanie Kliche, Florian Heyd, Ingo Schmitz, Christian Freund
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The question whether interference with the ubiquitous splicing machinery can lead to cell-type specific perturbation of cellular function is addressed here by T cell specific ablation of the general U5 snRNP assembly factor CD2BP2/U5–52K. This prot
Externí odkaz:
https://doaj.org/article/5bb2494462e24f849a03eadf17761b60
Autor:
Marco Preußner, Heather L Smith, Daniel Hughes, Min Zhang, Ann‐Kathrin Emmerichs, Silvia Scalzitti, Diego Peretti, Dean Swinden, Alexander Neumann, Tom Haltenhof, Giovanna R Mallucci, Florian Heyd
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 5, Pp 1-12 (2023)
Abstract Neurodegenerative diseases are increasingly prevalent in the aging population, yet no disease‐modifying treatments are currently available. Increasing the expression of the cold‐shock protein RBM3 through therapeutic hypothermia is remar
Externí odkaz:
https://doaj.org/article/a25ec675d94140af92e4424edd2c282c
Autor:
Karen Vester, Marco Preußner, Nicole Holton, Suihan Feng, Carsten Schultz, Florian Heyd, Markus C. Wahl
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Through the use of a reversible chemical dimerizer, the splicing factor PRPF38A is re-localized to the nuclear lamina, paving the way for a systematic analysis of spatio-temporal splicing regulation.
Externí odkaz:
https://doaj.org/article/ffdc066451914e1eaef33cc842e71134
Autor:
Alexandra Bergfort, Marco Preußner, Benno Kuropka, İbrahim Avşar Ilik, Tarek Hilal, Gert Weber, Christian Freund, Tuğçe Aktaş, Florian Heyd, Markus C. Wahl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Bergfort et al. use biochemistry, cryoEM, structure-guided mutagenesis, transcriptomics and proteomics to reveal how the intrinsically unstructured C9ORF78 protein binds BRR2 and PRPF8, regulating cassette exons and alternative 3’-splice sites.
Externí odkaz:
https://doaj.org/article/9cdd9c825b2e49b8b316d5d1c8d55312
Autor:
Marco Preussner, Qingsong Gao, Eliot Morrison, Olga Herdt, Florian Finkernagel, Michael Schumann, Eberhard Krause, Christian Freund, Wei Chen, Florian Heyd
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-24 (2020)
Abstract Background 3′-Untranslated regions (3′UTRs) play crucial roles in mRNA metabolism, such as by controlling mRNA stability, translation efficiency, and localization. Intriguingly, in some genes the 3′UTR is longer than their coding regio
Externí odkaz:
https://doaj.org/article/2201d5578c144f41bc65e2e846538ab0
Autor:
Stefan Meinke, Gesine Goldammer, A Ioana Weber, Victor Tarabykin, Alexander Neumann, Marco Preussner, Florian Heyd
Publikováno v:
eLife, Vol 9 (2020)
Minor and major spliceosomes control splicing of distinct intron types and are thought to act largely independent of one another. SR proteins are essential splicing regulators mostly connected to the major spliceosome. Here, we show that Srsf10 expre
Externí odkaz:
https://doaj.org/article/a5e4a712c4944de5ada55793e57744d3
Autor:
Ilka Wilhelmi, Regina Kanski, Alexander Neumann, Olga Herdt, Florian Hoff, Ralf Jacob, Marco Preußner, Florian Heyd
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The transport of secretory proteins from the endoplasmic reticulum to the Golgi depends on COPII-coated vesicles. Here, the authors show that activation-induced alternative splicing of Sec16 controls adaptation of COPII transport to increased secreto
Externí odkaz:
https://doaj.org/article/5eac4601c94e4e0ea0fcc66ec338cff3
Autor:
Marco Preußner, Heather L Smith, Daniel Hughes, Min Zhang, Ann‐Kathrin Emmerichs, Silvia Scalzitti, Diego Peretti, Dean Swinden, Alexander Neumann, Tom Haltenhof, Giovanna R Mallucci, Florian Heyd
Publikováno v:
EMBO Molecular Medicine. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ed1be64dd9333c0d0ad7b801d35a1e3
https://doi.org/10.15252/emmm.202217157
https://doi.org/10.15252/emmm.202217157
Autor:
Andreas Franz, A Ioana Weber, Marco Preußner, Nicole Dimos, Alexander Stumpf, Yanlong Ji, Laura Moreno-Velasquez, Anne Voigt, Frederic Schulz, Alexander Neumann, Benno Kuropka, Ralf Kühn, Henning Urlaub, Dietmar Schmitz, Markus C Wahl, Florian Heyd
Publikováno v:
Life science alliance
Regulation and functionality of species-specific alternative splicing has remained enigmatic to the present date. Calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) is expressed in several splice variants and plays a key role in learning and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9aa363a9dbde1039d69f0f18a544cd
http://edoc.mdc-berlin.de/22988/1/22988oa.pdf
http://edoc.mdc-berlin.de/22988/1/22988oa.pdf
Autor:
Olexandr Dybkov, Marco Preußner, Leyla El Ayoubi, Vivi-Yun Feng, Caroline Harnisch, Kilian Merz, Paula Leupold, Peter Yudichev, Dmitry E. Agafonov, Cindy L. Will, Cyrille Girard, Christian Dienemann, Henning Urlaub, Berthold Kastner, Florian Heyd, Reinhard Lührmann
Publikováno v:
Science Advances
Alternative precursor messenger RNA splicing is instrumental in expanding the proteome of higher eukaryotes, and changes in 3′ splice site (3'ss) usage contribute to human disease. We demonstrate by small interfering RNA–mediated knockdowns, foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219decd2dc12850c4405043971115062